1 Result for "

IDB-003

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "IDB-003" in MCE Product Catalog:

Cat. No.: HY-186311
CAS No.: 3079716-11-0
Target:  

c-Myc JNK

Research Areas:  

Cancer

IDB-003 is an orally active inhibitor of the human ribosomal peptidyl transferase center (PTC). IDB-003 exhibits antiproliferative activity against MYC-dependent cancer cells. IDB-003 binds to PTC, maintains ribosomal RNA interactions, blocks translation via context-dependent nascent polypeptide chain interactions, depletes MYC and CCND1, activates JNK phosphorylation through ribosomal collision, and downregulates the MYC target pathway. IDB-003 inhibits the growth of triple-negative breast cancer xenografts in mice. IDB-003 can be used for the research of triple-negative breast cancer .
loading...
    loading...