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Isoforms Recommended:	IL-23

Results for "

IL-12 p40

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (12) Akt (1) Apoptosis (1) Bacterial (1) Endogenous Metabolite (2) Environmental Pollutants (1) Epigenetic Reader Domain (1) Fungal (1) IFNAR (1) MHC (2) MMP (1) mTOR (1) NO Synthase (3) PGC-1α (1) Phosphodiesterase (PDE) (1) PI3K (1) PIKfyve (2) PPAR (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Salt-inducible Kinase (SIK) (1) Small Interfering RNA (siRNA) (1) TNF Receptor (4) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (3) Infection (2) Inflammation/Immunology (13) Metabolic Disease (2) Neurological Disease (2)
Oligonucleotides:	CpG ODNs (1) Emulsifiers (1) Mouse Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128754

Monoolein 1 Publications Verification	Environmental Pollutants Endogenous Metabolite NO Synthase Interleukin Related TNF Receptor	Inflammation/Immunology
Monoolein is a biocompatible lipid molecule that can be used as a carrier for bone repair. Monoolein exhibits anti-inflammatory activity by inhibiting the immune response induced by LPS (HY-D1056). It exerts its anti-inflammatory effects by reducing the production of immune response factors such as **IL-12 p40, IL-6, and TNF-α**, and inhibiting the generation of NO. Monoolein can be used in drug delivery and research in the field of inflammatory diseases .

HY-P99486

Briakinumab ABT-874	Interleukin Related	Inflammation/Immunology
Briakinumab (ABT-874) is a fully human anti-IL-12/23p40 monoclonal antibody. Briakinumab targets and neutralizes IL-12 and IL-23. Briakinumab can be used for the research of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis .

HY-P990225

*Anti-Mouse IL-12* p40 Antibody (C17.8)**	Interleukin Related	Metabolic Disease Inflammation/Immunology
Anti-Mouse IL-12 p40 Antibody (C17.8) is a rat-derived anti-mouse **IL-12 p40** IgG2a κ type antibody inhibitor. Anti-Mouse IL-12 p40 Antibody (C17.8) binds p40 subunit of IL-12. Anti-Mouse IL-12 p40 Antibody (C17.8) can be used for the researches of inflammation, immunology and metabolic disease, such as diabetes and arthritis .

HY-N2495

Isomucronulatol	Others	Inflammation/Immunology
Isomucronulatol is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol exhibits inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

HY-N3307

(+)-Medioresinol 1 Publications Verification	Bacterial Fungal Reactive Oxygen Species (ROS) Apoptosis MMP Interleukin Related PI3K Akt mTOR PPAR PGC-1α Pyroptosis	Infection Neurological Disease Inflammation/Immunology
(+)-Medioresinol is a furofuran-type lignan with antifungal and antibacterial properties. (+)-Medioresinol synergizes with antibiotics to exert antimicrobial and antibiofilm effects. (+)-Medioresinol induces intracellular ROS accumulation and mitochondrial-mediated apoptosis in Candida albicans. (+)-Medioresinol inhibits LPS (HY-D1056)-stimulated IL-12p40 production. (+)-Medioresinol is a PGC-1α activator that protects against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. (+)-Medioresinol can be used in research on fungal and bacterial infection, inflammation, and ischemic stroke .

HY-160231

ssRNA42 sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
ssRNA42 (sodium) is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. ssRNA42 (sodium) derives from ssRNA40 by replacement of all G nucleotides with adenosine. ssRNA42 activated human PBMCs to secrete IFN-α, TNF-a, IL- 12p40, and IL-6, but ssRNA42 failed to stimulated murine pDCs and PBMCs.

HY-155830

Morcamilast ME3183; PDE4-IN-14	Phosphodiesterase (PDE) Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Morcamilast (ME3183) is a selective and orally active PDE4 inhibitor, with IC₅₀s of 1.28 nM (PDE4A1A), 2.33 nM (PDE4B1), and 1.63 nM (PDE4D2) respectively. Morcamilast shows weak inhibition of PDEs other than PDE4s Morcamilast is an anti-inflammatory agent and inhibits LPS (HY-D1056)-induced release of TNF-α, *IL-12/23p40, IL-23, and IL-17A* in human PBMCs and T cells. Morcamilast has antipruritic effect and can be used in the study of psoriasis, atopic dermatitis, and other inflammatory diseases .

HY-N6250

Isomucronulatol 7-O-glucoside Isomucronulatol 7-O-β-glucoside	NO Synthase Interleukin Related	Inflammation/Immunology
Isomucronulatol 7-O-glucoside (Isomucronulatol 7-O-β-D-glucoside) is an isoflavonoid glycoside isolated from the roots of Astragalus membranaceus. Isomucronulatol 7-O-glucoside targets inflammation-related pathways in vitro to exert anti-inflammatory activity without cytotoxicity at effective concentrations. Isomucucronulatol 7-O-glucoside inhibits NO production and weakly suppresses **IL‑12 p40** production in vitro. Isomucronulatol 7-O-glucoside can be used for the research on inflammation .

HY-N4061

Hedycoronen A	Interleukin Related	Inflammation/Immunology
Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC₅₀s of 9.1 μM, 5.6 μM, and 46.0 μM. Hedycoronen A can be isolated from Hedychium coronarium .

HY-128754R

Monoolein (Standard)	Reference Standards Endogenous Metabolite Interleukin Related TNF Receptor NO Synthase	Inflammation/Immunology
Monoolein is a biocompatible lipid molecule that can be used as a carrier for bone repair. Monoolein exhibits anti-inflammatory activity by inhibiting the immune response induced by LPS (HY-D1056). It exerts its anti-inflammatory effects by reducing the production of immune response factors such as **IL-12 p40, IL-6, and TNF-α**, and inhibiting the generation of NO. Monoolein can be used in drug delivery and research in the field of inflammatory diseases .

HY-171591

SIK2-IN-4	Salt-inducible Kinase (SIK) Interleukin Related TNF Receptor	Infection
SIK2-IN-4 (Compound 4) is a highly selective SIK1/2 inhibitor (IC_50s 0.143 and 0.076 μM, respectively). SIK2-IN-4 reduces the phosphorylation of transcription coactivator 3 (CRTC3) by targeting SIK1/2, thereby regulating cAMP response element binding protein (CREB)-dependent transcriptional activity. SIK2-IN-4 inhibits the production of pro-inflammatory cytokines such as TNF (IC₅₀: 0.11 µM), IL-12/23 p40 (IC₅₀: 0.25 µM), and IL-23 (IC₅₀: 0.47 µM), while inducing the expression of the anti-inflammatory cytokine IL-10. SIK2-IN-4 can be used to study intestinal inflammation and other chronic inflammatory diseases .

HY-123876

AS2677131	PIKfyve Interleukin Related MHC	Inflammation/Immunology
AS2677131 is a potent and orally active PIKfyve inhibitor. AS2677131 inhibits f IL-12p40, IL-6 and IL-1β through a PIKfyve-c-Rel pathway. AS2677131 selectively inhibits DNA-binding activity of c-Rel to IL-12p40 and IL-1β promoter. AS2677131 inhibits MHC class II expression on B cells. AS2677131 can be used for the researches of inflammation and immunology, such as arthritis .

HY-177091

AS2795440	PIKfyve Interleukin Related MHC	Inflammation/Immunology
AS2795440 is a PIKfyve inhibitor. AS2795440 selectively inhibits proinflammatory cytokine such as *IL-12p40* and IL-6 production and B cell activation without affecting Ca ²⁺ signaling. AS2795440 significantly reduces joint inflammation and bone loss in adjuvant-induced arthritis (AIA) mice model. AS2795440 can be used for inflammatory and autoimmune diseases like rheumatoid arthritis, psoriasis and inflammatory bowel disease research .

HY-153900

TLR8 agonist 6	Toll-like Receptor (TLR)	Cancer
TLR8 agonist 6 (Compound A) is a TLR8 agonist, with an EC₅₀ of 0.052 μM. TLR8 agonist 6 induces IL-12p40 production in human PBMC (EC₅₀: 0.031 μM). TLR8 agonist 6 can be used in the research of virus resistance, infection resistance, autoimmunity, tumor, etc .

HY-P991408

DLX-105	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology
DLX-105 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa. DLX-105 reduces skin epidermal thickness and the expression of K16 and Ki67. DLX-105 down-regulates the mRNA levels of IL-17, TNF-α, IL-23p19, IL-12p40, and IFN-γ. DLX-105 can be used in psoriasis research .

HY-RS06681

Il12b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il12b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il12b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il12b Mouse Pre-designed siRNA Set A Il12b Mouse Pre-designed siRNA Set A

HY-147375

Bromodomain inhibitor-10	Epigenetic Reader Domain	Cancer
Bromodomain inhibitor-10 (compound 128) is a potent bromodomain inhibitor with K_ds of 15.0, 2500 nM for BRD4-1 and BRD4-2, respectively. Bromodomain inhibitor-10 inhibits the production of IL12p40 .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99486

Briakinumab ABT-874	Interleukin Related	Inflammation/Immunology
Briakinumab (ABT-874) is a fully human anti-IL-12/23p40 monoclonal antibody. Briakinumab targets and neutralizes IL-12 and IL-23. Briakinumab can be used for the research of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis .

HY-P990225

*Anti-Mouse IL-12* p40 Antibody (C17.8)**	Interleukin Related	Metabolic Disease Inflammation/Immunology
Anti-Mouse IL-12 p40 Antibody (C17.8) is a rat-derived anti-mouse **IL-12 p40** IgG2a κ type antibody inhibitor. Anti-Mouse IL-12 p40 Antibody (C17.8) binds p40 subunit of IL-12. Anti-Mouse IL-12 p40 Antibody (C17.8) can be used for the researches of inflammation, immunology and metabolic disease, such as diabetes and arthritis .

HY-P991408

DLX-105	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology
DLX-105 is a human monoclonal antibody (mAb) targeting TNFSF2/TNFa. DLX-105 reduces skin epidermal thickness and the expression of K16 and Ki67. DLX-105 down-regulates the mRNA levels of IL-17, TNF-α, IL-23p19, IL-12p40, and IFN-γ. DLX-105 can be used in psoriasis research .

Monoolein 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite NO Synthase Interleukin Related TNF Receptor
Monoolein is a biocompatible lipid molecule that can be used as a carrier for bone repair. Monoolein exhibits anti-inflammatory activity by inhibiting the immune response induced by LPS (HY-D1056). It exerts its anti-inflammatory effects by reducing the production of immune response factors such as **IL-12 p40, IL-6, and TNF-α**, and inhibiting the generation of NO. Monoolein can be used in drug delivery and research in the field of inflammatory diseases .

Isomucronulatol	Flavonoids other families Classification of Application Fields Leguminosae Phenols Polyphenols Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Other Flavonoids Inflammation/Immunology Disease Research Fields Source Classification	Others
Isomucronulatol is a flavonoid isolated from the roots of A. membranaceus. Isomucronulatol exhibits inhibitory effects on LPS-stimulated production IL-12 p40 in vitro and has potential anti-inflammatory effect .

(+)-Medioresinol 1 Publications Verification	Cardiovascular Disease Oleaceae Fraxinus mandshurica Rupr. Neurological Disease Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	Bacterial Fungal Reactive Oxygen Species (ROS) Apoptosis MMP Interleukin Related PI3K Akt mTOR PPAR PGC-1α Pyroptosis
(+)-Medioresinol is a furofuran-type lignan with antifungal and antibacterial properties. (+)-Medioresinol synergizes with antibiotics to exert antimicrobial and antibiofilm effects. (+)-Medioresinol induces intracellular ROS accumulation and mitochondrial-mediated apoptosis in Candida albicans. (+)-Medioresinol inhibits LPS (HY-D1056)-stimulated IL-12p40 production. (+)-Medioresinol is a PGC-1α activator that protects against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. (+)-Medioresinol can be used in research on fungal and bacterial infection, inflammation, and ischemic stroke .

Isomucronulatol 7-O-glucoside Isomucronulatol 7-O-β-glucoside	Structural Classification Classification of Application Fields Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Plants Monophenols Flavonoids other families Leguminosae Isoflavanones Phenols Inflammation/Immunology Disease Research Fields Source Classification	NO Synthase Interleukin Related
Isomucronulatol 7-O-glucoside (Isomucronulatol 7-O-β-D-glucoside) is an isoflavonoid glycoside isolated from the roots of Astragalus membranaceus. Isomucronulatol 7-O-glucoside targets inflammation-related pathways in vitro to exert anti-inflammatory activity without cytotoxicity at effective concentrations. Isomucucronulatol 7-O-glucoside inhibits NO production and weakly suppresses **IL‑12 p40** production in vitro. Isomucronulatol 7-O-glucoside can be used for the research on inflammation .

Hedycoronen A	Hedychium coronarium Koen. Terpenoids Diterpenoids Plants Source Classification Zingiberaceae	Interleukin Related
Hedycoronen A has inhibitory activity on the IL-6, IL-12 p40, and TNF-α production in LPS-Stimulated BMDCs, with IC₅₀s of 9.1 μM, 5.6 μM, and 46.0 μM. Hedycoronen A can be isolated from Hedychium coronarium .

Monoolein (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Interleukin Related TNF Receptor NO Synthase
Monoolein is a biocompatible lipid molecule that can be used as a carrier for bone repair. Monoolein exhibits anti-inflammatory activity by inhibiting the immune response induced by LPS (HY-D1056). It exerts its anti-inflammatory effects by reducing the production of immune response factors such as **IL-12 p40, IL-6, and TNF-α**, and inhibiting the generation of NO. Monoolein can be used in drug delivery and research in the field of inflammatory diseases .

Species:	Human (15) Marmoset (2) Rhesus Macaque (1) Rat (3) Mouse (14) Cynomolgus (1) Rabbit (2)
Tag:	His (24) Strep (1) Tag Free (8) Avi (2) Fc (6)
Source:	HEK293 (34) Sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72597

	IL-12 beta Protein, Mouse (HEK293, His) Interleukin-12 subunit beta; IL-12B; CLMF p40; IL-12 subunit p40	Mouse	HEK293
	IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 335 amino acids (M1-S335) with a fibronectin type-III domain (233-324 a.a). IL-12 beta Protein, Mouse (M23-S335) is produced in HEK293 cells with a C-Terminal His-tag.

HY-P74836

	IL-12 beta Protein, Rabbit (HEK293, His) Interleukin-12 subunit beta; IL-12B; IL-12 subunit p40; CLMF p40	Rabbit	HEK293
	IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 335 amino acids (M1-N324) with a fibronectin type-III domain (233-324 a.a). IL-12 beta Protein, Rabbit is produced in HEK293 cells with a C-Terminal His-tag.

HY-P701009

	IL-12 beta Protein, Cynomolgus (HEK293, His) IL-12B; CLMF p40; IL-12 subunit p40; NKSF2; CLMF; CLMF2; NKS	Cynomolgus	HEK293
	IL-12 beta protein binds to IL23A to produce the cytokine IL-23, which is critical for innate and adaptive immunity. IL-23, together with IL-17, orchestrates immediate infection responses in peripheral tissues. IL-12 beta Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-12 beta protein, expressed by HEK293 , with C-His labeled tag.

HY-P73161

	IL-12 beta Protein, Mouse (HEK293) Interleukin-12 subunit beta; IL-12B; CLMF p40; IL-12 subunit p40; NKSF2; IL12B	Mouse	HEK293
	IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 335 amino acids (M1-S335) with a fibronectin type-III domain (233-324 a.a). IL-12 beta Protein, Mouse (M1-S335) is produced in HEK293 cells with tag free.

HY-P73164

	IL-12 beta Protein, Rat (HEK293, His) Interleukin-12 subunit beta; IL-12B; CLMF p40; IL-12 subunit p40; NKSF2; IL12B	Rat	HEK293
	IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 335 amino acids (M1-S335) with a lg-like domain (43-90 a.a). IL-12 beta Protein, Rat (M1-S335) is produced in HEK293 cells with a C-Terminal His-tag.

HY-P77402

	IL-12 beta Protein, Marmoset (HEK293, Fc) Interleukin-12 subunit beta; IL-12B; CLMF p40; IL-12 subunit p40; NKSF2; IL12B	Marmoset	HEK293
	IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 335 amino acids (M1-N328) with a fibronectin type-III domain (233-324 a.a). IL-12 beta Protein, Marmoset is produced in HEK293 cells with a C-Terminal hFc-tag.

HY-P73162

	IL-12 beta Protein, Mouse (HEK293, Fc) Interleukin-12 subunit beta; IL-12B; CLMF p40; IL-12 subunit p40; NKSF2; IL12B	Mouse	HEK293
	IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 335 amino acids (M1-S335) with a fibronectin type-III domain (233-324 a.a). IL-12 beta Protein, Mouse (M1-S335) is produced in HEK293 cells with a C-Terminal hFc-tag.

HY-P74835

	IL-12 beta Protein, Rat (HEK293, Fc) Interleukin-12 subunit beta; IL-12B; CLMF p40; IL-12 subunit p40; NKSF2; IL12B	Rat	HEK293
	IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 335 amino acids (M1-S335) with a lg-like domain (43-90 a.a). IL-12 beta Protein, Rat (M1-S335) is produced in HEK293 cells with a C-Terminal hFc-tag.

HY-P70421

	IL-23 Protein, Mouse (sf9) SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2	Mouse	Sf9 insect cells
	IL-23 alpha is a key component that binds to IL12B to produce IL-23 interleukin, a heterodimeric cytokine critical in innate and adaptive immunity. IL-23 functions together with IL-17 in peripheral tissues to respond acutely to infection. IL-23 Protein, Mouse (sf9) is a recombinant protein dimer complex containing mouse-derived IL-23 alpha, expressed by sf9 insect cells , with tag free.

HY-P70709

	IL-23 Protein, Mouse (HEK293) SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2	Mouse	HEK293
	IL-23 alpha is a key component that binds to IL12B to produce IL-23 interleukin, a heterodimeric cytokine critical in innate and adaptive immunity. IL-23 functions together with IL-17 in peripheral tissues to respond acutely to infection. IL-23 alpha (175a.a) & IL-12 beta (313a.a) Heterodimer Protein, Mouse (HEK293) is a recombinant protein dimer complex containing mouse-derived IL-23 alpha, expressed by HEK293 , with tag free.

HY-P704382

	IL-23 Protein, Human (HEK293) IL-23 alpha (306a.a) & IL-12 beta (170a.a) Heterodimer; SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2	Human	HEK293

HY-P70736

	IL-23 Protein, Human (HEK293, C-His) IL-23 alpha (306a.a) & IL-12 beta (170a.a) Heterodimer; SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2	Human	HEK293
	IL-23 and IL12B together constitute the pro-inflammatory cytokine IL-23, which is crucial in innate and adaptive immunity. IL-23 is released by antigen-presenting cells such as dendritic cells or macrophages, binds to IL12RB1 and IL23R, and activates JAK2 and TYK2. IL-23 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived IL-23 alpha & IL-12 beta protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7032

	IL-12 Protein, Human (HEK293) 3 Publications Verification IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40	Human	HEK293
	IL-12 Protein, Human (HEK293) is a HEK293 cell derived heterodimeric, pro-inflammatory cytokine.

HY-P70666

	IL-12 Protein, Mouse (HEK293) 1 Publications Verification IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40;	Mouse	HEK293
	IL-12 protein is a immune-suppressive heterodimeric cytokine, composed by IL-12A subunit (IL-12p35) and IL-12B subunit (IL-12p40), is naturally produced by dendritic cells. IL-12 exerts functions to activate and link the innate and acquired immune responses. IL-12 Protein, Mouse is produced in HEK293 cells, with tag free.

HY-P7032G

	*GMP IL-12* Protein, Human (HEK293)** IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40	Human	HEK293
	Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. GMP IL-12 Protein, Human (HEK293), a recombinant GMP-grade protein, is produced in HEK293 cells. It consists of IL-12A and IL-12B.

HY-P73156

	*GMP IL-12* Protein, Human (HEK293, His)** GMP IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40	Human	HEK293
	Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 Protein, Human (HEK293, His), a recombinant GMP-grade protein, is produced in HEK293 cells with a C-Terminal His-tag . It consists of IL-12A (M1-S219) and IL-12B (M1-S328).

HY-P73159

	IL-12 Protein, Mouse (HEK293, His) IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40	Mouse	HEK293
	Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 Protein, Mouse (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of IL-12A (M1-A215) and IL-12B (M1-S335).

HY-P73160

	IL-12 beta Protein, Human (HEK293, Fc) IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40	Human	HEK293
	IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 328 amino acids (M1-S328) with a fibronectin type-III domain (237-328 a.a). IL-12 beta Protein, Human (M1-S328) is produced in HEK293 cells with a C-Terminal Fc-tag.

HY-P73897

	IL-12 Protein, Rhesus Macaque (HEK293, His) IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40	Rhesus Macaque	HEK293
	Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 Protein, Rhesus Macaque (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag . It consists of IL-12A (M1-S219) and IL-12B (M1-S328).

HY-P73157

	IL-12 Protein, Mouse (HEK293, Fc) IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40	Mouse	HEK293
	Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 Protein, Mouse (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of IL-12A (M1-A215) and IL-12B (M1-S335).

HY-P73158

	IL-12 Protein, Mouse (HEK293, His-Fc) IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40	Mouse	HEK293
	Interleukin-12 subunit alpha (IL-12A; IL-12p35), an immune-suppressive cytokine, encodes a subunit of the cytokine IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. IL-12A heterodimerizes with IL-12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 Protein, Mouse (HEK293, His-Fc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag. It consists of IL-12A (M1-A215) and IL-12B (M1-S335).

HY-P77511

	IL-12 Protein, Human (Biotinylated, HEK293, His) IL-12; Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40	Human	HEK293
	IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 328 amino acids (M1-S328) with a fibronectin type-III domain (237-328 a.a). IL-12 beta Protein, Human (M1-S219) is a biotinylated protein, produced in HEK293 cells with a C-Terminal His-tag.

HY-P70617

	IL-12 beta Protein, Human (HEK293) Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2; IL12B; NKSF2	Human	HEK293
	IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 328 amino acids (M1-S328) with a fibronectin type-III domain (237-328 a.a). IL-12 beta Protein, Human (I23-S328) is produced in HEK293 cells with tag free.

HY-P700100AF

	*Animal-Free IL-12* beta Protein, Human (His)** Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2; IL12B; NKSF2	Human	E. coli
	IL-12 beta protein is a multifunctional cytokine that serves as a growth factor for activated T cells and NK cells, amplifies the lytic activity of NK/lymphokine-activated killer cells, and induces IFN production by resting peripheral blood mononuclear cells -γ. peripheral blood mononuclear cells). Animal-Free IL-12 beta Protein, Human (His) is the recombinant human-derived animal-FreeIL-12 beta protein, expressed by E. coli , with His labeled tag. This product is for cell culture use only.

HY-P704384

	IL-12 beta Protein, Human (HEK293, His) Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2; IL12B; NKSF2	Human	HEK293
	IL-12 beta protein is a multifunctional cytokine that serves as a growth factor for activated T cells and NK cells, amplifies the lytic activity of NK/lymphokine-activated killer cells, and induces IFN production by resting peripheral blood mononuclear cells -γ. peripheral blood mononuclear cells). IL-12 beta Protein, Human (HEK293, His) is the recombinant human-derived IL-12 beta protein, expressed by HEK293, with C-His labeled tag.

HY-P700191AF

	*Animal-Free IL-12* beta Protein, Mouse (His)** Interleukin-12 subunit beta; IL-12 subunit p40; IL-12B; Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit (CLMF p40); NK cell Stimulating Factor Chain 2	Mouse	E. coli
	IL-12 beta protein is a cytokine that acts as a growth factor for activated T cells and NK cells, enhances lytic activity and stimulates IFN-γ production. It combines with IL23A to form IL-23, a cytokine critical in innate and adaptive immunity. Animal-Free IL-12 beta Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-12 beta protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P70604

	IL-23 Protein, Mouse (HEK293, C-His) SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2; IL-23; Interleukin-23	Mouse	HEK293
	IL-23 alpha is a key component that binds to IL12B to produce IL-23 interleukin, a heterodimeric cytokine critical in innate and adaptive immunity. IL-23 functions together with IL-17 in peripheral tissues to respond acutely to infection. IL-23 Protein, Mouse (HEK293, C-His) is a recombinant protein dimer complex containing mouse-derived IL-23 alpha, expressed by HEK293 , with C-6*His labeled tag.

HY-P78861

	IL-12 beta Protein, Mouse (Biotinylated, HEK293, His-Avi) IL12B; CLMF; CLMF2; NKSF; NKSF2; p40	Mouse	HEK293
	IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 335 amino acids (M1-S335) with a fibronectin type-III domain (233-324 a.a). IL-12 beta Protein, Mouse (M23-S335) is produced in HEK293 cells with a C-Terminal His- and Avi-tag.

HY-P705224

	IL-12 beta Protein, Human (Biotinylated, HEK293, His-Avi) Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2; IL12B; NKSF2	Human	HEK293

HY-P700101AF

	*Animal-Free IL-12* Protein, Human (HEK293, His)** Interleukin 12; Interleukin-12 subunit alpha; IL-12A; Cytotoxic lymphocyte maturation factor 35 kDa subunit; CLMF p35; IL-12 subunit p35; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40	Human	HEK293
	IL-35 protein plays a key role in immune regulation, forming IL-12 cytokine with IL12B or IL-35 cytokine with EBI3/IL27B. IL-12 modulates T cell and natural killer cell responses and induces interferon gamma production. Animal-Free IL-12 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived animal-FreeIL-12 protein, expressed by HEK293 , with C-His labeled tag. Animal-Free IL-12 Protein, Human (HEK293, His), has molecular weight of ~59.55 kDa.This product is for cell culture use only.

HY-P74874

	*Human IL-23 alpha & Mouse IL-12* beta Heterodimer Protein (HEK293, His)** IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Mouse;Human	HEK293
	IL-23 and IL12B together constitute the pro-inflammatory cytokine IL-23, which is crucial in innate and adaptive immunity. IL-23 is released by antigen-presenting cells such as dendritic cells or macrophages, binds to IL12RB1 and IL23R, and activates JAK2 and TYK2. Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His) is a recombinant protein dimer complex containing mouse, human-derived Human IL-23 alpha & Mouse IL-12 beta Heterodimer protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73195

	IL-23 Protein, Rat (HEK293, His) 1 Publications Verification IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Rat	HEK293
	IL-23 alpha protein has cytokine activity and binds to the interleukin 23 receptor. It regulates cytokine production, lymphocyte activation, and peptidyl tyrosine phosphorylation. IL-23 Protein, Rat (HEK293, His) is a recombinant protein dimer complex containing rat-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P73193

	IL-23 Protein, Human (HEK293, His) IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Human	HEK293
	IL-23 and IL12B together constitute the pro-inflammatory cytokine IL-23, which is crucial in innate and adaptive immunity. IL-23 is released by antigen-presenting cells such as dendritic cells or macrophages, binds to IL12RB1 and IL23R, and activates JAK2 and TYK2. IL-23 Protein, Human (HEK293, His) is a recombinant protein dimer complex containing human-derived IL-23 alpha & IL-12 beta, expressed by HEK293 , with C-His labeled tag.

HY-P73887

	IL-23 Protein, Rabbit (HEK293, His) IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Rabbit	HEK293
	IL-23 alpha protein is part of the IL-6 superfamily and contains IL-23 alpha and IL-12 beta subunits that form a biologically active complex. It has a crucial impact on the differentiation and activation of Th17 cells associated with autoimmune diseases. IL-23 Protein, Rabbit (HEK293, His) is a recombinant protein dimer complex containing Rabbit-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293 , with C-His labeled tag.

HY-P74814

	IL-23 Protein, Mouse (HEK293, His) IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Mouse	HEK293
	IL-23 alpha is a key component that binds to IL12B to produce IL-23 interleukin, a heterodimeric cytokine critical in innate and adaptive immunity. IL-23 functions together with IL-17 in peripheral tissues to respond acutely to infection.IL-23 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived IL-23 alpha & IL-12 beta, expressed by HEK293 , with C-His labeled tag.

HY-P73194

	IL-23 Protein, Marmoset (HEK293, His) IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Marmoset	HEK293
	IL-23 alpha protein, a member of the IL-6 superfamily, is featured. IL-23 Protein, Marmoset (HEK293, His) is a recombinant protein dimer complex containing Marmoset-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293 , with C-His labeled tag. IL-23 Protein, Marmoset (HEK293, His), has molecular weight of ~22 & 45 kDa, respectively.

HY-P74816

	IL-23 Protein, Human (Biotinylated, HEK293, His) 1 Publications Verification IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF	Human	HEK293
	IL-23 and IL12B together constitute the pro-inflammatory cytokine IL-23, which is crucial in innate and adaptive immunity. IL-23 is released by antigen-presenting cells such as dendritic cells or macrophages, binds to IL12RB1 and IL23R, and activates JAK2 and TYK2. IL-23 Protein, Human (Biotinylated, HEK293, His) is a recombinant protein dimer complex containing human-derived IL-23 alpha & IL-12 beta, expressed by HEK293 , with C-His labeled tag.

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HY-P83008

	IL-12 beta Antibody (YA2753) IL12B; NKSF2; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2	WB	Human
	IL-12 beta Antibody (YA2753) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-12 beta.

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Cat. No.	Product Name		Classification

HY-128754

Monoolein 1 Publications Verification		Emulsifiers
Monoolein is a biocompatible lipid molecule that can be used as a carrier for bone repair. Monoolein exhibits anti-inflammatory activity by inhibiting the immune response induced by LPS (HY-D1056). It exerts its anti-inflammatory effects by reducing the production of immune response factors such as **IL-12 p40, IL-6, and TNF-α**, and inhibiting the generation of NO. Monoolein can be used in drug delivery and research in the field of inflammatory diseases .

HY-160231

ssRNA42 sodium		CpG ODNs
ssRNA42 (sodium) is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. ssRNA42 (sodium) derives from ssRNA40 by replacement of all G nucleotides with adenosine. ssRNA42 activated human PBMCs to secrete IFN-α, TNF-a, IL- 12p40, and IL-6, but ssRNA42 failed to stimulated murine pDCs and PBMCs.

HY-RS06681

Il12b Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Il12b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il12b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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IL-12 p40

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