40957-99-1
Chemical Structure
(+)-Medioresinol
- CAS No.: 40957-99-1
- Formula:C21H24O7
- Molecular Weight:388.41
IUPAC Name: 4-((1S,3aR,4S,6aR)-4-(4-hydroxy-3-methoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl)-2,6-dimethoxyphenol
InChIKey: VJOBNGRIBLNUKN-BMHXQBNDSA-N
SMILES: COC1=C(O)C(OC)=CC([C@]2([H])[C@]3([H])[C@@](CO2)([H])[C@](C4=CC(OC)=C(C=C4)O)([H])OC3)=C1
Biological Activity: (+)-Medioresinol is a furofuran-type lignan with antifungal and antibacterial properties. (+)-Medioresinol synergizes with antibiotics to exert antimicrobial and antibiofilm effects. (+)-Medioresinol induces intracellular ROS accumulation and mitochondrial-mediated apoptosis in Candida albicans. (+)-Medioresinol inhibits LPS (HY-D1056)-stimulated IL-12p40 production. (+)-Medioresinol is a PGC-1α activator that protects against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. (+)-Medioresinol can be used in research on fungal and bacterial infection, inflammation, and ischemic stroke[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(+)-Medioresinol | 99.13% | (+)-Medioresinol is a furofuran-type lignan with antifungal and antibacterial properties. (+)-Medioresinol synergizes with antibiotics to exert antimicrobial and antibiofilm effects. (+)-Medioresinol induces intracellular ROS accumulation and mitochondrial-mediated apoptosis in Candida albicans. (+)-Medioresinol inhibits LPS (HY-D1056)-stimulated IL-12p40 production. (+)-Medioresinol is a PGC-1α activator that protects against endothelial cell pyroptosis in ischemic stroke via the PPARα-GOT1 axis. (+)-Medioresinol can be used in research on fungal and bacterial infection, inflammation, and ischemic stroke. | ||||||||||||||||||||
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References
- [1]. Ji Hong Hwang, et al. (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans. Biochimie. 2012 Aug;94(8):1784-93. [Content Brief]
- [2]. Ji Hong Hwang, et al. Synergistic antibacterial and antibiofilm effect between (+)-medioresinol and antibiotics in vitro. Appl Biochem Biotechnol. 2013 Aug;170(8):1934-41. [Content Brief]
- [3]. Nhiem NX, et al. Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. J Nat Prod. 2013 Apr 26;76(4):495-502. [Content Brief]
- [4]. Qin X, et al. Medioresinol from Eucommiae cortex improves myocardial infarction-induced heart failure through activation of the PI3K/AKT/mTOR pathway: A network analysis and experimental study. PLoS One. 2024 Sep 27;19(9):e0311143. [Content Brief]
- [5]. Wang Y, et al. Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis. Pharmacol Res. 2021 Jul;169:105640. [Content Brief]
