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Leishmania spp

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) Interleukin Related (1) Mitochondrial Metabolism (3) Parasite (6)
By Research Areas:	Infection (7) Inflammation/Immunology (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990227

Anti-Mouse IL-12 Antibody (R1-5D9)	Interleukin Related Bacterial	Infection Inflammation/Immunology
Anti-Mouse IL-12 Antibody (R1-5D9) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse IL-12. Anti-Mouse IL-12 Antibody (R1-5D9) can neutralize IL-12. Anti-Mouse IL-12 Antibody (R1-5D9) can be used for the researches of infection, inflammation and immunology, such as Leishmania infection and skin inflammation .

HY-19688B

Sitamaquine tosylate WR 6026 tosylate	Parasite Mitochondrial Metabolism	Infection
Sitamaquine (WR6026) tosylate, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine tosylate inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine tosylate is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes .

HY-P11155

Halictine 2	Parasite	Infection
Halictine 2 is an antimicrobial peptide. Halictine 2 exhibits promising anti-parasitic activity against Leishmania spp., targeting both the extracellular infective metacyclic promastigotes and intracellular amastigotes. Halictine 2 can be used for the study of leishmaniases .

HY-19688A

Sitamaquine hydrochloride WR 6026 hydrochloride	Parasite Mitochondrial Metabolism	Infection
Sitamaquine (WR6026) hydrochloride, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine hydrochloride inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine hydrochloride is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes .

HY-178064

Antiparasitic agent-29	Parasite Mitochondrial Metabolism	Infection
Antiparasitic agent-29 (Compound 5) is a Trypanosome alternative oxidase (TAO) inhibitor with an IC₅₀ of 1.3 nM in Trypanosoma brucei. Antiparasitic agent-29 has a broad-spectrum antiparasitic activity against Trypanosoma and Leishmania spp. Antiparasitic agent-29 accumulates in parasite mitochondria, selectively disrupting its energy metabolism and has potent membrane-perturbing activity with no cross-resistance. Antiparasitic agent-29 shows low ecotoxicity in zebrafish and Daphnia magna models. Antiparasitic agent-29 can be used for parasitic diseases like surra and dourine research .

HY-179584

Antileishmanial agent-38	Parasite	Infection
Antileishmanial agent-38 (compound 197) is a host-directed small molecule antileishmanial agent exhibiting potent broad-spectrum activity against *Leishmania* *spp. Antileishmanial agent-38 inhibits intracellular parasites primarily by targeting the host protein lysozyme, while also displaying direct activity against extracellular L. donovani* promastigotes. Antileishmanial agent-38 can be used for leishmaniasis research .

HY-W341759

1,4-Dihydrazinylphthalazine	Parasite	Infection
1,4-Dihydrazinylphthalazine (Compound 2) is an antiparasitic agent targeting Leishmania spp. 1,4-Dihydrazinylphthalazine is promising for research of tropical diseases, particularly cutaneous leishmaniasis .

Cat. No.	Product Name	Target	Research Area

HY-P11155

Halictine 2	Parasite	Infection
Halictine 2 is an antimicrobial peptide. Halictine 2 exhibits promising anti-parasitic activity against Leishmania spp., targeting both the extracellular infective metacyclic promastigotes and intracellular amastigotes. Halictine 2 can be used for the study of leishmaniases .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990227

Anti-Mouse IL-12 Antibody (R1-5D9)	Interleukin Related Bacterial	Infection Inflammation/Immunology
Anti-Mouse IL-12 Antibody (R1-5D9) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse IL-12. Anti-Mouse IL-12 Antibody (R1-5D9) can neutralize IL-12. Anti-Mouse IL-12 Antibody (R1-5D9) can be used for the researches of infection, inflammation and immunology, such as Leishmania infection and skin inflammation .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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