1019640-33-5
Chemical Structure
Sitamaquine tosylate
Synonym(s): WR 6026 tosylate
- CAS No.: 1019640-33-5
- Formula:C28H41N3O4S
- Molecular Weight:515.71
IUPAC Name: N1,N1-diethyl-N6-(6-methoxy-4-methylquinolin-8-yl)hexane-1,6-diamine 4-methylbenzenesulfonate
InChIKey: LOBPWLFCZDGYKW-UHFFFAOYSA-N
SMILES: CC1=CC=NC2=C(NCCCCCCN(CC)CC)C=C(OC)C=C12.O=S(C3=CC=C(C)C=C3)(O)=O
Biological Activity: Sitamaquine (WR6026) tosylate, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine tosylate inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine tosylate is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes[1][2].
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Sitamaquine tosylate | Sitamaquine (WR6026) tosylate, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine tosylate inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine tosylate is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes. | |||||||||||||||||||||
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References
- [1]. López-Martín C, et al. Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes. Antimicrob Agents Chemother. 2008;52(11):4030-4036. [Content Brief]
- [2]. Luis Carvalho, et al. The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase. Antimicrob Agents Chemother. 2011 Sep;55(9):4204-10. [Content Brief]
