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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
MC4R antagonist
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "MC4R antagonist" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-P0227
CAS No.: 168482-23-3
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1 Cited Publications
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PF-07258669 is an orally active melanocortin-4 receptor (MC4R) antagonist that antagonizes MC4R with an IC50 of 13 nM (Ki=0.46 nM). PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa .
Cat. No.: HY-P5971
CAS No.: 1456699-27-6
Synonyms: Mifomelatide
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ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity .
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ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 μM and 0.103 μM, respectively. ML-00253764 can cross blood-brain barrier .
Cat. No.: HY-P5971A
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Cat. No.: HY-183106
CAS No.: 3038478-21-3
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MC4R antagonist-2 is a potent melanocortin 4 receptor (MC4R) antagonist with an IC50 of 0.54 nM. MC4R antagonist-2 can be used for the research of MC4R-mediated conditions, such as cachexia, osteoporosis, neuropathic pain, depression, hypertension, malnutrition-related obesity, and associated inflammatory diseases .
Cat. No.: HY-W559510
CAS No.: 746661-28-9
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MC4R antagonist-3 is a benzimidazole or imidazopyridine derivative, as well as a MC4R antagonist with affinity for melanocortin receptors. MC4R antagonist-3 can be used in research related to inflammatory diseases, neuropathic pain, anxiety disorders, depressive disorders and skin diseases .
Cat. No.: HY-182773
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MC4R Antagonist-1 (compound 1) is an MC4R-selective antagonist (IC50<10 nM). MC4R Antagonist-1 can be used for the research of cachexia, anorexia, anorexia nervosa, involuntary weight loss, failure to thrive, sarcopenia, muscle wasting, muscle weakness, frailty, osteoporosis .
Cat. No.: HY-148349A
CAS No.: 2755890-68-5
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(2R,2R)-PF-07258669 is a MC4R (melanocortin 4 receptor) antagonist. (2R,2R)-PF-07258669 can be used in the study of regulating appetite and energy expenditure .
Cat. No.: HY-121764
CAS No.: 884538-31-2
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MPCI is a cell-permeant MC4R-selective ligand with pharmacological chaperone activity. MPCI is a MC4R antagonist with a Ki value of 0.218 μM on HEK293 cells expressing hMC4R. MPCI can be used for the research of MC4R-deficient obesity .
Cat. No.: HY-110123R
CAS No.: 1706524-94-8
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ML-00253764 hydrochloride (Standard) is the analytical standard of ML-00253764 (hydrochloride) (HY-110123). This product is intended for research and analytical applications. ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 μM and 0.103 μM, respectively. ML-00253764 can cross blood-brain barrier .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
