2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. ML00253764

ML00253764 

Cat. No.: HY-124740 Purity: 99.70%
COA Handling Instructions

ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity.

For research use only. We do not sell to patients.

ML00253764 Chemical Structure

ML00253764 Chemical Structure

CAS No. : 681847-92-7

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Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 165 In-stock
Solid
5 mg USD 150 In-stock
10 mg USD 250 In-stock
25 mg USD 440 In-stock
50 mg USD 700 In-stock
100 mg USD 1100 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity[1].

In Vitro

ML00253764 (0.001-50 μM, 24 h or 72 h) has significant time- and concentration-dependent inhibitory activity on the proliferation of human glioblastoma cells, and the IC50 value for U-118 cells is 6.56 μM, which can induce U -87 cells apoptosis and show significant inhibition of ERK1/2 phosphorylation in both cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ML00253764 Related Antibodies
In Vivo

ML00253764(30 mg/kg, s.c., daily, 34 days) can inhibit inhibit tumor growth in CD nu/nu male mice infected with U-87 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

377.25

Appearance

Solid

Formula

C18H18BrFN2O
CAS No.
SMILES

FC1=C(CCC2=CC(Br)=CC=C2OC)C(C3=NCCN3)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 66.67 mg/mL (176.73 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6508 mL 13.2538 mL 26.5076 mL
5 mM 0.5302 mL 2.6508 mL 5.3015 mL
10 mM 0.2651 mL 1.3254 mL 2.6508 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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ML00253764 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ML00253764681847-92-7ML 00253764ML-00253764Melanocortin ReceptorMC ReceptorMC4RERK1/2AktapoptosisanticancerInhibitorinhibitorinhibit

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