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Cat. No.: HY-183106

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MC4R antagonist-2

MC4R antagonist-2 is a potent melanocortin 4 receptor (MC4R) antagonist with an IC₅₀ of 0.54 nM. MC4R antagonist-2 can be used for the research of MC4R-mediated conditions, such as cachexia, osteoporosis, neuropathic pain, depression, hypertension, malnutrition-related obesity, and associated inflammatory diseases.

For research use only. We do not sell to patients.

CAS No.: 3038478-21-3
Formula: C₂₆H₂₉F₃N₆O₃
Molecular Weight:530.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MC4R antagonist-2 Chemical Structure

CAS No.: 3038478-21-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

MC4R

0.54 nM (IC₅₀)

All Melanocortin Receptor Isoforms :

In Vitro

MC4R antagonist-2 (Compound I) (10 min) exhibits potent MC4R antagonistic activity in flipin-293-MC4 cells, with an IC₅₀ of 0.54 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3038478-21-3
Molecular Weight 530.55
Formula C₂₆H₂₉F₃N₆O₃
SMILES

N([C@H]1C2(CN(C([C@H](C)C=3C=C(OC)N=CC3F)=O)C1)CC2)C=4N=C(C)C(=CC4)C=5N=C(OC(F)F)N(C)C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xiaobing Zhang, et al. Polymorph of mc4r antagonist, and preparation method therefor and use thereof. WO2025237404A1. 2025-11-20

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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MC4R antagonist-2

All Melanocortin Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

MC4R antagonist-2 Related Classifications

HY-183106 Related Classifications