1706524-94-8
1706524-94-8
Chemical Structure
ML-00253764 hydrochloride
- CAS No.: 1706524-94-8
- Formula:C18H19BrClFN2O
- Molecular Weight:413.71
IUPAC Name: 2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-4,5-dihydro-1H-imidazole hydrochloride
InChIKey: KZUMGPQDDCBFBF-UHFFFAOYSA-N
SMILES: FC1=C(CCC2=CC(Br)=CC=C2OC)C(C3=NCCN3)=CC=C1.[H]Cl
Biological Activity: ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 μM and 0.103 μM, respectively. ML-00253764 can cross blood-brain barrier[1][2].
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ML-00253764 hydrochloride | 99.29% | ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 μM and 0.103 μM, respectively. ML-00253764 can cross blood-brain barrier. | ||||||||||||||||||||
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References
- [1]. Vos TJ, et al. Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model. J Med Chem. 2004 Mar 25;47(7):1602-4. [Content Brief]
- [2]. Пюрвеев С С, Лебедев А А, Бычков Е Р, et al. Исследование роли меланоцитстимулирующего гормона в организации эмоционального и исследовательского поведения у крыс[J].
Keywords
