Search Result

Isoforms Recommended:	MHC I

Results for "

MHC I

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MHC (50) Apoptosis (2) Arenavirus (2) Autophagy (1) Bacterial (1) Beclin1 (1) c-Fms (2) Cannabinoid Receptor (1) Caspase (1) CD3 (1) CD74 (1) CETP (1) DNA Methyltransferase (1) EGFR (1) Endogenous Metabolite (1) FAK (1) Fc Receptor (FcR) (1) G protein-coupled Bile Acid Receptor 1 (2) HBV (1) Histone Methyltransferase (1) HIV (2) HSP (1) HSV (1) IFNAR (1) Influenza Virus (2) Isotope-Labeled Compounds (1) JAK (2) LILRB (3) Phosphatase (1) PROTACs (4) Proteasome (1) Protein Arginine Deiminase (1) RNA MTase (1) RSV (1) TAM Receptor (2) Transmembrane Glycoprotein (3) Tyrosinase (1) ULK (1) Wnt (2)
By Research Areas:	Cancer (29) Cardiovascular Disease (2) Infection (8) Inflammation/Immunology (38) Metabolic Disease (3) Neurological Disease (2)

By Targets:

MHC (50)

Apoptosis (2)

Arenavirus (2)

Autophagy (1)

Bacterial (1)

Beclin1 (1)

c-Fms (2)

Cannabinoid Receptor (1)

Caspase (1)

CD3 (1)

CD74 (1)

CETP (1)

DNA Methyltransferase (1)

EGFR (1)

Endogenous Metabolite (1)

FAK (1)

Fc Receptor (FcR) (1)

G protein-coupled Bile Acid Receptor 1 (2)

HBV (1)

Histone Methyltransferase (1)

HIV (2)

HSP (1)

HSV (1)

IFNAR (1)

Influenza Virus (2)

Isotope-Labeled Compounds (1)

JAK (2)

LILRB (3)

Phosphatase (1)

PROTACs (4)

Proteasome (1)

Protein Arginine Deiminase (1)

RNA MTase (1)

RSV (1)

TAM Receptor (2)

Transmembrane Glycoprotein (3)

Tyrosinase (1)

ULK (1)

Wnt (2)

By Research Areas:

Cancer (29)

Cardiovascular Disease (2)

Infection (8)

Inflammation/Immunology (38)

Metabolic Disease (3)

Neurological Disease (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: MHC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1489

OVA Peptide(257-264) Maximum Cited Publications 15 Publications Verification	MHC	Inflammation/Immunology
OVA Peptide(257-264) is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb.

HY-P1489A

OVA Peptide(257-264) TFA Maximum Cited Publications 15 Publications Verification	MHC	Inflammation/Immunology
OVA Peptide(257-264) TFA is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb.

HY-158301

MY-1B 1 Publications Verification	DNA Methyltransferase RNA MTase	Others
MY-1B is a covalent inhibitor of the RNA Methyltransferase NSUN2 (IC₅₀: 1.3 μM). MY-1B stereoselectively ligands active-site cysteine residues (C271) of NSUN2. MY-1B can stereoselectively and covalently bind to PSME1, disrupting the proteasome regulatory complex and downregulating the presentation of specific MHC-I subtypes .

HY-126855

Cholic acid 7-sulfate 1 Publications Verification 7-Sulfocholic acid	G protein-coupled Bile Acid Receptor 1 MHC	Metabolic Disease
Cholic acid 7-sulfate (7-Sulfocholic acid) is a selective agonist targeting TGR5 (EC₅₀=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation .

HY-123606

GSK484 Maximum Cited Publications 49 Publications Verification	Protein Arginine Deiminase MHC	Cardiovascular Disease Inflammation/Immunology
GSK484 is a PAD4 inhibitor that effectively inhibits protein citrullination and the formation of neutrophil extracellular traps (NETs) by blocking the catalytic activity of PAD4. GSK484 suppresses the production of histone H3, *MHC-I* expression, CD8 ⁺ T cell activation, proliferation and inflammatory cytokine release. GSK484 reduces inflammation and bone destruction in collagen-induced rheumatoid arthritis, alleviates pain and mast cell activation in sickle cell disease, and improves myocardial ischemia-reperfusion injury and experimental colitis. In addition, GSK484 restores intestinal microbial homeostasis by reversing ferroptosis-induced dysbiosis. GSK484 can be used to study the disease mechanisms of rheumatoid arthritis, sickle cell disease, thrombosis, myocardial injury, colitis and other conditions .

HY-P990195

*Anti-Mouse MHC* Class I (H-2) Antibody (M1/42.3.9.8)**	MHC	Others
Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) reacts with the mouse H-2 MHC class I alloantigen (all haplotypes). Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) can be used for the flow cytometry and immunofluorescence experiments .

HY-P1569

LCMV gp33-41 3 Publications Verification LCMV GP(33-41) M-peptide; gp33 epitope	Arenavirus	Infection Inflammation/Immunology
LCMV gp33-41, the carboxyl-extended 9-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes .

HY-152830

Adrixetinib Q702	c-Fms TAM Receptor MHC	Cancer
Adrixetinib (Q702) is an orally active triple inhibitor against CSF1R, Mer, and Axl, with K_d values of 8.7 nM, 0.8 nM, and 0.3 nM, respectively. Adrixetinib acts as a potent immune modulator that remodels the tumor microenvironment. Adrixetinib increases the abundance of M1 macrophages and CD8⁺ T cells, while decreasing the levels of M2 macrophages and myeloid-derived suppressor cells (MDSCs). Adrixetinib upregulates the expression of MHC class I and E-cadherin in tumor cells. Adrixetinib shows remarkable antitumor efficacy in syngeneic mouse tumor models. Adrixetinib is suitable for the research of breast cancer, renal adenocarcinoma, colon carcinoma, and melanoma .

HY-P3715

OVA peptide 2 Publications Verification	MHC	Inflammation/Immunology
OVA peptide mainly exists in egg white, it is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC). OVA peptide has been widely studied in allergy research .

HY-P4193

AH1	MHC	Inflammation/Immunology Cancer
AH1 is an immunodominant MHC class I-restricted nonamer peptide recognized by CD8 ⁺ cytotoxic T lymphocytes. AH1 derives from the envelope protein (gp70) of an endogenous ecotropic murine leukemia virus and is presented by the MHC class I L ^d molecule. AH1 can be used for the research of colorectal carcinoma .

HY-P6312

ESAT6 Epitope	MHC	Inflammation/Immunology
ESAT6 Epitope is a ESAT6 CD4 ⁺ T cell epitope. ESAT6 Epitope binds to MHC class I molecules with an IC₅₀ value of approximately 180 nM. ESAT6 Epitope has weak immunogenicity. ESAT6 Epitope can be used in studies related to pulmonary tuberculosis .

HY-P99129

Anti-Mouse CD8a Antibody (53-6.7) 3 Publications Verification	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-Mouse CD8a Antibody (53-6.7) is an anti-mouse CD8a IgG2a antibody inhibitor derived from host Rat. Anti-Mouse CD8a Antibody (53-6.7) binds to CD8αβ stabilizes a conformation with a higher affinity for interaction with MHC class I. Anti-Mouse CD8a Antibody (53-6.7) induces the phosphorylation and activation of TCR proximal signaling pathway components Lck and ZAP70 in polyclonal memory T cells. Anti-Mouse CD8a Antibody (53-6.7) depletes CD8+ T cells and neutralizes cytokine in mice .

HY-P11303

PADRE peptide	CD74 MHC	Neurological Disease Cancer
PADRE peptide is a pan-HLA-DR binding epitope and immunostimulant. PADRE peptide binds to the peptide-binding groove of MHC class II molecules for presentation to CD4 ⁺ T cells, thereby effectively stimulating specific immune responses. PADRE peptide not only enhances anti-tumor immune responses, inhibits tumor growth and prolongs survival; it also significantly increases the frequency of E7-specific CD8 ⁺ T cells and improves therapeutic efficacy against TC-1 tumors when used in combination with E7 peptide-based vaccines and poly (I:C). The intensity of the immune response induced by PADRE peptide is lower than that of the Ii-PADRE DNA vaccine, and it fails to enhance the immune effect of CRT-E7 DNA. PADRE peptide is widely applicable to research on related tumors such as melanoma, glioblastoma and cervical cancer .

HY-D1474

WNT7A-IN-1 sodium	Wnt	Cancer
WNT7A-IN-1 sodium (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 sodium significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin . WNT7A-IN-1 sodium (compound F) is also a photographic sensitizer in the green spectral region .

HY-P5411

OVA-T4 Peptide SIITFEKL, OVA (257-264) Variant	MHC	Others
OVA-T4 Peptide (SIITFEKL, OVA (257-264) Variant) is a low-affinity variant of OVA (257-264) (SIINFEKL). OVA-T4 Peptide has similar binding to H-2Kb MHC class I molecules as OVA (257-264), but has a much lower affinity for the OT-I TCR25 .

HY-P990187

*Anti-Mouse MHC* Class II (I-A/I-E) Antibody (M5/114)**	MHC Influenza Virus	Infection Inflammation/Immunology
Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) does not react with I-Af, I-Ak, or I-As haplotypes. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) blocks MHC Class II and inhibit T cell generation. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) can be used for the researches of infection and immunology, such as influenza A virus (IAV) infection .

HY-P1585

Gp100 (25-33), human 1 Publications Verification Hgp100 (25-33)	MHC	Cancer
Gp100 (25-33), human (Hgp100 (25-33)) is the amino acids 25-33 fragment of the human melanoma antigen. Gp100 (25-33), human is a 9-amino acid (AA) epitope restricted by MHC class I H-2D ^b and recognized by the T cells. Gp100 (25-33), human has immunogenicity and induces specific T cells. Gp100 (25-33), human can be used for the cancer research, such as melanoma .

HY-P11058

OVA(250-264) OVAp	MHC	Cancer
OVA(250-264) (OVAvac) (OVAp) is an antigen peptide that can be from ovalbumin (OVA) presented by the class I *MHC* molecule, H-2Kb. OVA(250-264) combined withαMSLN (anti-MSLN antibody) significantly induces antigen-specific CD8 ⁺ T cell generation and infiltration for enhancing antitumor efficacy in orthotopic pancreatic cancer mice model. OVA(250-264) can be used for neoantigen vaccine development in pancreatic cancer immunotherapy research .

HY-171860

FC-14369	PROTACs HIV	Infection Cancer
FC-14369 is a PROTAC degrader targeting the HIV-1 Nef protein, with a DC₅₀ value of 160 nM. Through its bifunctional structure, FC-14369 binds to Nef and the Cereblon E3 ubiquitin ligase, induces Nef ubiquitination and proteasomal degradation, restores the expression of cell-surface CD4 and MHC-I, and inhibits HIV-1 replication. FC-14369 can be used in research on HIV infection and AIDS. FC-14369 is applicable to studies related to HIV-1 infection .

HY-P990832

*Anti-MHC* Class I Antibody (W6/32)**	MHC	Inflammation/Immunology
Anti-MHC Class I Antibody (W6/32) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human MHC Class I. Anti-MHC Class I Antibody (W6/32) reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, and C. Anti-MHC Class I Antibody (W6/32) increases adherence of monocytes to human endothelial cells. Anti-MHC Class I Antibody (W6/32) can be used for the research of immunology .

HY-P2455

LLO (91-99) Listeriolysin O (91-99)	Bacterial	Infection Inflammation/Immunology
LLO (91-99) (Listeriolysin O (91-99)) is an exotoxin and class I MHC-restricted T-cell epitope of listeriolysin (LLO). LLO (91-99) is processed by antigen-presenting cells, binds to MHC class I molecules and is presented to the cell surface. LLO (91-99) induces CTL responses and effectively eliminates Listeria from infected cells. LLO (91-99) can be used in the research of Listeria infections (e.g., listeriosis) .

HY-170411

WNT7A-IN-1	Wnt	Cancer
WNT7A-IN-1 (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin. WNT7A-IN-1 (compound F) is also a photographic sensitizer in the green spectral region .

HY-P990188

*Anti-Mouse MHC* class II (I-A) Antibody (Y-3P)**	MHC	Inflammation/Immunology
Anti-Mouse MHC class II (I-A) Antibody (Y-3P) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC class II. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) reacts with mouse MHC Class II haplotypes I-Ab, I-Af, I-Ap, I-Aq, I-Ar, I-As, I-Au, I-Av, and weakly with I-Ak. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) blocks MHC class II and inhibits expansion of regulate T cells. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) can be used for the immunology research .

HY-P2527

Tyrosinase-related Protein 2 (TRP-2) (181-188)	Tyrosinase	Inflammation/Immunology
Tyrosinase-related Protein 2 (TRP-2) (181-188) is a tyrosinase-related protein 2 (TRP-2)-derived peptide, corresponding to residues 180-188. Tyrosinase-related Protein 2 (TRP-2) (181-188) is the major reactive epitope within TRP-2 recognized by anti-B16 CTLs. Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide conforming to the MHC class I H2-Kb binding motif .

HY-P990193

*Anti-Mouse MHC* Class I (H-2Kd, H-2Dd) Antibody (34-1-2S)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) is an anti-mouse MHC Class I (H-2Kd, H-2Dd) IgG2a monoclonal antibody. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can block the interaction between Ly49 and MHC-I. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can be used for the construction of acute lung injury models .

HY-P99135

*Anti-Mouse MHC* Class I (H-2Kb) Antibody (Y-3)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) is a mouse-derived IgG2b antibody inhibitor, targeting to mouse MHC Class I (H-2Kb). Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) reacts with the mouse H-2Kb, H-2Kk, H-2Kq, H-2Kr, H-2ks MHC class I alloantigens and not H-2Kd. Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) can block MHC Class I. Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) can be used for immunology research .

HY-P5410

OVA-Q4 Peptide	MHC	Others
OVA-Q4 Peptide is a biological active peptide. (Q4 Peptide (SIIQFEKL) is a variant of the agonist ovalbumin (OVA) peptide (257-264), SIINFEKL. OVA Peptide is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC).)

HY-P1569A

LCMV gp33-41 TFA 3 Publications Verification LCMV GP(33-41) M-peptide TFA; gp33 epitope TFA	Arenavirus	Inflammation/Immunology
LCMV gp33-41 (TFA), the carboxyl-extended 9-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes .

HY-P1837

Influenza HA (518-526)	Influenza Virus HSV	Infection
Influenza HA (518-526) is an H-2d-restricted CTL epitope derived from influenza virus hemagglutinin. Influenza HA (518-526) is highly conserved across various H5N1, some H9N2, and H1N1 strains. Influenza HA (518-526) binds to the mouse MHC class I allele K ^d to form a complex, which is then recognized by specific CD8 ⁺ T cells. Influenza HA (518-526) is an immunodominant epitope in influenza-infected BALB/c mice, and it stimulates CD8 ⁺ T cells to secrete IFN-γ to induce a robust immune response. Currently, Influenza HA (518-526) is widely used in research related to respiratory syncytial virus (RSV), influenza virus, and H5N1 influenza .

HY-162965

Immunoproteasome activator 1	Proteasome	Cancer
Immunoproteasome activator 1 (compound A) is a selective immunoproteasome activator that increases the presentation of individual *MHC-I*–bound peptides by over 100-fold. Immunoproteasome activator 1 binds to the proteasome structural subunit PSMA1 and promotes the association of the proteasome activator PA28α/β (PSME1/PSME2) with immunoproteasomes .

HY-P1585A

Gp100 (25-33), human TFA 1 Publications Verification Hgp100 (25-33) TFA	MHC	Cancer
Gp100 (25-33), human TFA (Hgp100 (25-33) (TFA)) is the amino acids 25-33 fragment of the human melanoma antigen. Gp100 (25-33), human TFA is a 9-amino acid (AA) epitope restricted by MHC class I H-2D ^b and recognized by the T cells. Gp100 (25-33), human TFA has immunogenicity and induces specific T cells. Gp100 (25-33), human TFA can be used for the cancer research, such as melanoma .

HY-P2525

GAD65 (206-220)	MHC	Inflammation/Immunology
GAD65 (206-220) is glutamic acid decarboxylase (GAD) 65-derived peptide, corresponding to residues 180-188. GAD65 is presented to T cells in association with I-Ag7 MHC class II molecules and a major pancreatic antigens targeted by self-reactive T cells in type I diabetes mellitus .

HY-P10582A

SIYNFEKL TFA	MHC	Inflammation/Immunology
SIYNFEKL TFA is a variant of major MHC class I-restricted epitope SIINFEKL. SIYNFEKL TFA is an antigenic peptide, that can stimulate specific T cells in experimental settings to study the competitive interaction between T cell. SIYNFEKL TFA exhibits low affinity for the OT-I T cell receptor (TCR), and can be used for detection of CD8+ T cells .

HY-P10581A

SIIVFEKL TFA	MHC	Inflammation/Immunology
SIIVFEKL TFA is a variant of the major MHC class I-restricted epitope SIINFEKL. SIIVFEKL TFA is an antigenic peptide, that can stimulate specific T cells in experimental settings to study the competitive interaction between T cells. SIIVFEKL TFA exhibits low affinity for the OT-I T cell receptor (TCR), and can be used for detection of CD8+ T cells .

HY-P5453

CFP10 (71–85)	CD3	Others
CFP10 (71–85) is a biological active peptide. (CFP1071–85, that elicited IFN-γ production and CTL activity by both CD4+ and CD8+ T cells from persons expressing multiple MHC class II and class I molecules)

HY-171883

BI-5756	Cannabinoid Receptor CETP MHC	Metabolic Disease Inflammation/Immunology Cancer
BI-5756 is a CETP inhibitor and cannabinoid receptor 1 (CB1) agonist. BI-5756 can significantly increase HDL-C levels and reduce LDL-C levels. BI-5756 can also enhance the function of regulatory T cells while maintaining T cell-mediated anti-tumor activity. BI-5756 can directly inhibit the growth of tumor cells and upregulate the expression of MHC I, MHC II, and CD80 on tumor cells. BI-5756 has a protective effect in graft-versus-host disease models. BI-5756 can be used in research on tumors, graft-versus-host disease, and metabolic diseases .

HY-160151

TP1L	PROTACs Phosphatase JAK IFNAR MHC	Cancer
TP1L is a potent and selective T-cell protein tyrosine phosphatase (TC-PTP) PROTAC degrader, with a DC₅₀ value of 35.8 nM. TP1L elevates the phosphorylation level of TC-PTP substrates including pSTAT1 and pJAK1. TP1L selectively enhances IFN-γ signaling and increases *MHC-I* expression. TP1L activates TCR signaling through increases phosphorylation of LCK. TP1L enhances CAR-T cell mediated tumor killing efficacy through activation of the CAR-T cells. TP1L can be used for the study of cancer. (Pink: TC-PTP ligand: (HY-138964), Blue: E3 ligase CRBN Ligand (HY-A0003), Black: Linker: (HY-140002)) .

HY-P990185

*Anti-Mouse/Rat MHC* Class II (I-Ek/RT1-D) Antibody (14-4-4S)**	MHC	Inflammation/Immunology Cancer
Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/rat MHC Class II. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) reacts with mouse MHC Class II alloantigen I-Ek and the rat MHC class II alloantigen RT1D. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) blocks antigen presentation. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) can be used for the research of immunology and cancer .

HY-P990192

*Anti-Mouse MHC* Class I (H-2Kk) Antibody (AF3-12.1.3)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) is a mouse-derived IgG1 type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) reacts with the mouse H-2Kk MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) can be used for the researches of inflammation and immunology, such as obliterative airway disease .

HY-P990061

Polzastobart JTX 8064	LILRB Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antagonist antibody that selectively binds LILRB2 and prevents it from binding its ligands, classical and non-classical MHC I molecules. Polzastobart enhances pro-inflammatory cytokine production in macrophages by blocking the ability of LILRB2 to bind HLA-A/B and/or HLA-G, a marker of immunotolerance on cancer cells. Polzastobart is a macrophage immune checkpoint inhibitor .

HY-P990194

*Anti-Mouse MHC* Class I (H-2Kd) Antibody (HB-159)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) reacts with the mouse H-2Kd MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) can be used for immunology research, such as cardiac graft .

HY-P990190

*Anti-Swine MHC* Class I (SLAd) Antibody (74-11-10)**	MHC	Others
Anti-Swine MHC Class I (SLAd) Antibody (74-11-10) is a mouse-derived IgG2b κ type antibody inhibitor, targeting to *Swine MHC* Class I*. Anti-Swine MHC* Class I (SLAd) Antibody (74-11-10) reacts with the swine leucocyte antigen (SLA) class I. Anti-Swine MHC Class I (SLAd) Antibody (74-11-10) can be used for the research of flow cytometry experiments .

HY-P990813

*Anti-Mouse Nonclassical MHC* Class I molecule Qa-1b Antibody (4C2.4A7.5H11)**	MHC	Cancer
Anti-Mouse Nonclassical MHC Class I molecule Qa-1b Antibody (4C2.4A7.5H11) is a mouse-derived IgG1 antibody inhibito, targeting to mouse *Nonclassical MHC* Class I molecule Qa-1b*. Anti-Mouse Nonclassical MHC* Class I molecule Qa-1b Antibody (4C2.4A7.5H11) reacts with the mouse non-classical MHC class I molecule Qa-1b. Anti-Mouse Nonclassical MHC Class I molecule Qa-1b Antibody (4C2.4A7.5H11) can be used for the research of cancer, such as B16F10 tumor .

HY-P990191

*Anti-Mouse MHC* Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13))**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) reacts with the mouse H-2Kk and H-2Dk MHC class I alloantigens. Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) can be used for immunology research .

HY-P1489B

OVA Peptide(257-264) acetate salt	MHC	Inflammation/Immunology
OVA Peptide(257-264) acetate salt is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb .

HY-106156

Allotrap 07	MHC	Cardiovascular Disease Inflammation/Immunology
Allotrap 07 is a synthetic peptide composed of residues 75-84 of HLA-B7, a class I MHC molecule. Allotrap 07 combined with Cyclosporin A (HY-B0579) induces donor-specific tolerance in rat cardiac allografts, significantly prolonging graft survival .

HY-179211

CliMB-325	HSP MHC	Cancer
CliMB-325 is an HSP90 inhibitor that can induce *MHC-I* (EC₅₀ = 498 nM) expression on the surface of CT26 murine colorectal cancer cells. CliMB-325 enhances T cell activation and exhibits lower toxicity. CliMB-325 can be used for the study of colorectal cancer .

HY-175459

PROTAC FAK degrader 3	PROTACs FAK	Inflammation/Immunology Cancer
PROTAC FAK degrader 3 is a selective FAK PROTAC degrader (DC₅₀ = 1.08 nM). PROTAC FAK degrader 3 induces FAK degradation dependent on the ubiquitin-proteasome system and its binding to FAK and CRBN. PROTAC FAK degrader 3 upregulates MHC-I gene transcription and tumor cell surface expression by inhibiting the non-catalytic activity of FAK, leading to increased antigen presentation and activation of cytotoxic CD8 T cells. PROTAC FAK degrader 3 enhances in vivo anti-tumor activity by promoting MHC-I expression and enhancing T cell activation. PROTAC FAK degrader 3 can be used in cancer research targeting FAK degradation in ovarian cancer, hepatocellular carcinoma, and other cancers. (Pink: FAK-IN-3:HY-143407, Blue: Thalidomide-4-OH:HY-103596, Blue + Black: FAK ligand-3: HY-W939883, Black: Linker) .

HY-P990186

*Anti-Mouse MHC* Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2)**	MHC	Others
Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) is a mouse-derived IgG2c κ type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) reacts with mouse MHC Class II haplotypes I-Ak, I-Ar, I-Af, I-As, and I-Ag7. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) does not react with I-Ab, I-Ad, I-Ap, or I-Aq haplotypes. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) blocks MHC Class II and inhibits antigen proliferation responses. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) can be used for the research of immunology .

HY-171859

FC-14367	PROTACs HIV	Cancer
FC-14367 is a PROTAC degrader targeting HIV-1 Nef protein. FC-14367 forms a ternary complex by binding Nef and Cereblon E3 ubiquitin ligase, inducing Nef ubiquitination and proteasomal degradation, restoring cell-surface CD4 and MHC-I expression and inhibiting HIV-1 replication. FC-14367 can be used in research on HIV infection and AIDS . (Black: Glycolic acid (HY-W015967); Blue: 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (HY-138793))

Cat. No.	Product Name	Target	Research Area

HY-P1489

OVA Peptide(257-264) Maximum Cited Publications 15 Publications Verification	MHC	Inflammation/Immunology
OVA Peptide(257-264) is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb.

HY-P1489A

OVA Peptide(257-264) TFA Maximum Cited Publications 15 Publications Verification	MHC	Inflammation/Immunology
OVA Peptide(257-264) TFA is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb.

HY-P1569

LCMV gp33-41 3 Publications Verification LCMV GP(33-41) M-peptide; gp33 epitope	Arenavirus	Infection Inflammation/Immunology
LCMV gp33-41, the carboxyl-extended 9-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes .

HY-P3715

OVA peptide 2 Publications Verification	MHC	Inflammation/Immunology
OVA peptide mainly exists in egg white, it is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC). OVA peptide has been widely studied in allergy research .

HY-P4193

AH1	MHC	Inflammation/Immunology Cancer
AH1 is an immunodominant MHC class I-restricted nonamer peptide recognized by CD8 ⁺ cytotoxic T lymphocytes. AH1 derives from the envelope protein (gp70) of an endogenous ecotropic murine leukemia virus and is presented by the MHC class I L ^d molecule. AH1 can be used for the research of colorectal carcinoma .

HY-P6312

ESAT6 Epitope	MHC	Inflammation/Immunology
ESAT6 Epitope is a ESAT6 CD4 ⁺ T cell epitope. ESAT6 Epitope binds to MHC class I molecules with an IC₅₀ value of approximately 180 nM. ESAT6 Epitope has weak immunogenicity. ESAT6 Epitope can be used in studies related to pulmonary tuberculosis .

HY-P11303

PADRE peptide	CD74 MHC	Neurological Disease Cancer
PADRE peptide is a pan-HLA-DR binding epitope and immunostimulant. PADRE peptide binds to the peptide-binding groove of MHC class II molecules for presentation to CD4 ⁺ T cells, thereby effectively stimulating specific immune responses. PADRE peptide not only enhances anti-tumor immune responses, inhibits tumor growth and prolongs survival; it also significantly increases the frequency of E7-specific CD8 ⁺ T cells and improves therapeutic efficacy against TC-1 tumors when used in combination with E7 peptide-based vaccines and poly (I:C). The intensity of the immune response induced by PADRE peptide is lower than that of the Ii-PADRE DNA vaccine, and it fails to enhance the immune effect of CRT-E7 DNA. PADRE peptide is widely applicable to research on related tumors such as melanoma, glioblastoma and cervical cancer .

HY-P5411

OVA-T4 Peptide SIITFEKL, OVA (257-264) Variant	MHC	Others
OVA-T4 Peptide (SIITFEKL, OVA (257-264) Variant) is a low-affinity variant of OVA (257-264) (SIINFEKL). OVA-T4 Peptide has similar binding to H-2Kb MHC class I molecules as OVA (257-264), but has a much lower affinity for the OT-I TCR25 .

HY-P1585

Gp100 (25-33), human 1 Publications Verification Hgp100 (25-33)	MHC	Cancer
Gp100 (25-33), human (Hgp100 (25-33)) is the amino acids 25-33 fragment of the human melanoma antigen. Gp100 (25-33), human is a 9-amino acid (AA) epitope restricted by MHC class I H-2D ^b and recognized by the T cells. Gp100 (25-33), human has immunogenicity and induces specific T cells. Gp100 (25-33), human can be used for the cancer research, such as melanoma .

HY-P11058

OVA(250-264) OVAp	MHC	Cancer
OVA(250-264) (OVAvac) (OVAp) is an antigen peptide that can be from ovalbumin (OVA) presented by the class I *MHC* molecule, H-2Kb. OVA(250-264) combined withαMSLN (anti-MSLN antibody) significantly induces antigen-specific CD8 ⁺ T cell generation and infiltration for enhancing antitumor efficacy in orthotopic pancreatic cancer mice model. OVA(250-264) can be used for neoantigen vaccine development in pancreatic cancer immunotherapy research .

HY-P2455

LLO (91-99) Listeriolysin O (91-99)	Bacterial	Infection Inflammation/Immunology
LLO (91-99) (Listeriolysin O (91-99)) is an exotoxin and class I MHC-restricted T-cell epitope of listeriolysin (LLO). LLO (91-99) is processed by antigen-presenting cells, binds to MHC class I molecules and is presented to the cell surface. LLO (91-99) induces CTL responses and effectively eliminates Listeria from infected cells. LLO (91-99) can be used in the research of Listeria infections (e.g., listeriosis) .

HY-P2494

OVA (55-62)	Peptides	Inflammation/Immunology
OVA 55-62 is a fragmented peptide of OVA (ovalbumin) antigen and can bind to the mouse MHC class I molecule, H2-Kb .

HY-P2527

Tyrosinase-related Protein 2 (TRP-2) (181-188)	Tyrosinase	Inflammation/Immunology
Tyrosinase-related Protein 2 (TRP-2) (181-188) is a tyrosinase-related protein 2 (TRP-2)-derived peptide, corresponding to residues 180-188. Tyrosinase-related Protein 2 (TRP-2) (181-188) is the major reactive epitope within TRP-2 recognized by anti-B16 CTLs. Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide conforming to the MHC class I H2-Kb binding motif .

HY-P5410

OVA-Q4 Peptide	MHC	Others
OVA-Q4 Peptide is a biological active peptide. (Q4 Peptide (SIIQFEKL) is a variant of the agonist ovalbumin (OVA) peptide (257-264), SIINFEKL. OVA Peptide is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC).)

HY-P5412

LLO (190-201) Listeriolysin O 190 peptide	Peptides	Others
LLO (190-201) (Listeriolysin O 190 peptide) is a biological active peptide. (This peptide is a major histocompatibility complex class II (MHC-II)-restricted peptide, LLO190 (NEKYAQAYPNVS), from the listeriolysin O protein of Listeria monocytogenes, which generates an LLO190-specific Th response. This peptide subsequently challenge recombinant L. monocytogenes expressing the MHC-I-restricted epitope of ovalbumin (Ova257, SIINFEKL).)

HY-P1569A

LCMV gp33-41 TFA 3 Publications Verification LCMV GP(33-41) M-peptide TFA; gp33 epitope TFA	Arenavirus	Inflammation/Immunology
LCMV gp33-41 (TFA), the carboxyl-extended 9-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes .

HY-P1837

Influenza HA (518-526)	Influenza Virus HSV	Infection
Influenza HA (518-526) is an H-2d-restricted CTL epitope derived from influenza virus hemagglutinin. Influenza HA (518-526) is highly conserved across various H5N1, some H9N2, and H1N1 strains. Influenza HA (518-526) binds to the mouse MHC class I allele K ^d to form a complex, which is then recognized by specific CD8 ⁺ T cells. Influenza HA (518-526) is an immunodominant epitope in influenza-infected BALB/c mice, and it stimulates CD8 ⁺ T cells to secrete IFN-γ to induce a robust immune response. Currently, Influenza HA (518-526) is widely used in research related to respiratory syncytial virus (RSV), influenza virus, and H5N1 influenza .

HY-P1585A

Gp100 (25-33), human TFA 1 Publications Verification Hgp100 (25-33) TFA	MHC	Cancer
Gp100 (25-33), human TFA (Hgp100 (25-33) (TFA)) is the amino acids 25-33 fragment of the human melanoma antigen. Gp100 (25-33), human TFA is a 9-amino acid (AA) epitope restricted by MHC class I H-2D ^b and recognized by the T cells. Gp100 (25-33), human TFA has immunogenicity and induces specific T cells. Gp100 (25-33), human TFA can be used for the cancer research, such as melanoma .

HY-P2525

GAD65 (206-220)	MHC	Inflammation/Immunology
GAD65 (206-220) is glutamic acid decarboxylase (GAD) 65-derived peptide, corresponding to residues 180-188. GAD65 is presented to T cells in association with I-Ag7 MHC class II molecules and a major pancreatic antigens targeted by self-reactive T cells in type I diabetes mellitus .

HY-P10582A

SIYNFEKL TFA	MHC	Inflammation/Immunology
SIYNFEKL TFA is a variant of major MHC class I-restricted epitope SIINFEKL. SIYNFEKL TFA is an antigenic peptide, that can stimulate specific T cells in experimental settings to study the competitive interaction between T cell. SIYNFEKL TFA exhibits low affinity for the OT-I T cell receptor (TCR), and can be used for detection of CD8+ T cells .

HY-P10581A

SIIVFEKL TFA	MHC	Inflammation/Immunology
SIIVFEKL TFA is a variant of the major MHC class I-restricted epitope SIINFEKL. SIIVFEKL TFA is an antigenic peptide, that can stimulate specific T cells in experimental settings to study the competitive interaction between T cells. SIIVFEKL TFA exhibits low affinity for the OT-I T cell receptor (TCR), and can be used for detection of CD8+ T cells .

HY-P5453

CFP10 (71–85)	CD3	Others
CFP10 (71–85) is a biological active peptide. (CFP1071–85, that elicited IFN-γ production and CTL activity by both CD4+ and CD8+ T cells from persons expressing multiple MHC class II and class I molecules)

HY-P1489B

OVA Peptide(257-264) acetate salt	MHC	Inflammation/Immunology
OVA Peptide(257-264) acetate salt is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb .

HY-106156

Allotrap 07	MHC	Cardiovascular Disease Inflammation/Immunology
Allotrap 07 is a synthetic peptide composed of residues 75-84 of HLA-B7, a class I MHC molecule. Allotrap 07 combined with Cyclosporin A (HY-B0579) induces donor-specific tolerance in rat cardiac allografts, significantly prolonging graft survival .

HY-P11061

M27 peptide	Peptides	Cancer
M27 peptide is an MHC class I epitope antigen that can be used in cancer nanovaccine research .

HY-P10535

AAV-8 NSL epitope	Peptides	Others
The AAV-8 NSL epitope is a specific CD8+ T cell epitope identified from the capsid of an adeno-associated virus (AAV) serotype 8. The AAV-8 NSL epitope has a high affinity for MHC I molecules and is able to bind to MHC I molecules, thereby activating CD8+ T cells. The AAV-8 NSL epitope can be used to study the impact of T cell-mediated immune responses on AAV-mediated gene transfer .

HY-P4044

HBV Seq2 aa:28-39	HBV	Infection
HBV Seq2 aa:28-39 is a HBsAg peptide, which binds to major histocompatibility complex (MHC) class I molecules .

HY-P10296

p60 (217–225)	Endogenous Metabolite	Infection
p60 (217–225) is the subdominant epitope of Listeria monocytogenes, which combines with H-2K ^d MHC class I molecules .

HY-P10433

EGFRvIII peptide	Apoptosis	Cancer
EGFRvIII peptide is an EGFRvIII-derived epitope for binding to MHC I molecules. EGFRvIII peptide induces apoptosis, and causes specific immune responses against glioblastoma, especially in combination with Flagellin B .

HY-P5745

TYVPANASL	Transmembrane Glycoprotein	Cancer
TYVPANASL is a MHC I-binding CD8 T cell epitope of nine amino acids from HER2/neu. TYVPANASL can be used to prepare J-LEAPS vaccine .

HY-P5745A

TYVPANASL TFA	MHC EGFR	Cancer
TYVPANASL TFA is a MHC I-binding CD8 T cell epitope of nine amino acids from HER2/neu. TYVPANASL TFA can be used to prepare J-LEAPS vaccine .

HY-P10245

Fusion glycoprotein (92-106)	RSV	Inflammation/Immunology
Fusion glycoprotein 92-106 is a polypeptide from fusion protein of respiratory syncytial virus (RSV). Fusion glycoprotein 92-106 acts as MHC class I-restricted CTL epitope, that all 15 amino acids are required for efficient recognition by cytotoxic T lymphocyte (CTL) .

HY-P10840

Tkip	JAK MHC	Inflammation/Immunology
Tkip is a JAK2 specific inhibitor. Tkip can bind the JAK2 autophosphorylation site, inhibit the JAK2 autophosphorylation and the phosphorylation of the IFN-γ receptor subunit IFNGR-1. Tkip inhibits the antiviral activity of IFN-γ and the expression of MHC Class I molecules. Tkip can be used to study the IFN-γ signaling pathway .

HY-P10525

MBP Ac1-9 (4Y)	Peptides	Neurological Disease
MBP Ac1-9 (4Y) is a synthetic peptide derived from a fragment of myelin basic protein (MBP) that has undergone specific chemical modifications. MBP Ac1-9 (4Y) is able to form a complex with the MHC class II molecule I-Au and activate specific T cell receptor (TCR), thus playing a role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). MBP Ac1-9 (4Y) can be used to study autoimmune diseases, especially those involving the central nervous system, such as multiple sclerosis .

HY-P3070

H2-D b restricted epitopes VSV Nucleoprotein (52-59)	MHC	Infection Others
H2-D b restricted epitopes VSV Nucleoprotein (52-59) is a 9-mer peptide derived from the nucleoprotein of Vesicular Stomatitis Virus (VSV). H2-D b restricted epitopes VSV Nucleoprotein (52-59) binds to MHC class I molecules and presents itself to CD8+ T cells, thereby activating cytotoxic T lymphocytes (CTLs), which can recognize and kill cells expressing the corresponding antigen. H2-D b restricted epitopes VSV Nucleoprotein (52-59) can be used in the development of CTL vaccines against Ebola virus .

HY-P2674

KDEL	MHC	Inflammation/Immunology Cancer
KDEL is a tetrapeptide serving as an endoplasmic reticulum (ER) retrieval/retention signal. KDEL can target and deliver exogenous antigen peptides to the ER, significantly enhance and prolong MHC class I molecule presentation, and effectively boost anti-tumor immune responses .

HY-P11701

SEIDLILGY	MHC	Others
SEIDLILGY is a nonapeptide identified as a peptide ligand derived from mouse major histocompatibility complex class I (MHC). SEIDLILGY serves as a tool chemical stimulant for the specific activation of sensory neurons expressing the particular vomeronasal receptor (V2rf2) .

HY-P11700

AAPDARETA	MHC	Inflammation/Immunology
AAPDARETA is a mutated *MHC*-associated peptide with reduced binding affinity to H-2D ^b MHC molecules. AAPDARETA activates subsets of mouse main olfactory epithelium sensory neurons and induces Ca ²⁺ transients .

HY-P11397

VLPDVFIRCV	MHC	Cancer
VLPDVFIRCV, a melanoma antigen-derived peptide, is the intron sequence (nt 38-67) of the N-acetylglucosamine transferase V (GnT-V) gene. VLPDVFIRCV has a high affinity for MHC-I class molecules, but it cannot activate the immune response against natural tumor cells. The cytotoxic T lymphocytes (CTL) induced by VLPDVFIRCV can specifically lyse T2 cells loaded with this peptide in the chromium release experiment. VLPDVFIRCV can be used for vaccine design research .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990195

*Anti-Mouse MHC* Class I (H-2) Antibody (M1/42.3.9.8)**	MHC	Others
Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) reacts with the mouse H-2 MHC class I alloantigen (all haplotypes). Anti-Mouse MHC Class I (H-2) Antibody (M1/42.3.9.8) can be used for the flow cytometry and immunofluorescence experiments .

HY-P99129

Anti-Mouse CD8a Antibody (53-6.7) 3 Publications Verification	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-Mouse CD8a Antibody (53-6.7) is an anti-mouse CD8a IgG2a antibody inhibitor derived from host Rat. Anti-Mouse CD8a Antibody (53-6.7) binds to CD8αβ stabilizes a conformation with a higher affinity for interaction with MHC class I. Anti-Mouse CD8a Antibody (53-6.7) induces the phosphorylation and activation of TCR proximal signaling pathway components Lck and ZAP70 in polyclonal memory T cells. Anti-Mouse CD8a Antibody (53-6.7) depletes CD8+ T cells and neutralizes cytokine in mice .

HY-P990187

*Anti-Mouse MHC* Class II (I-A/I-E) Antibody (M5/114)**	MHC Influenza Virus	Infection Inflammation/Immunology
Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) does not react with I-Af, I-Ak, or I-As haplotypes. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) blocks MHC Class II and inhibit T cell generation. Anti-Mouse MHC Class II (I-A/I-E) Antibody (M5/114) can be used for the researches of infection and immunology, such as influenza A virus (IAV) infection .

HY-P990832

*Anti-MHC* Class I Antibody (W6/32)**	MHC	Inflammation/Immunology
Anti-MHC Class I Antibody (W6/32) is a kind of mouse IgG2a κ chimeric antibody inhibitor, targeting to human MHC Class I. Anti-MHC Class I Antibody (W6/32) reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, and C. Anti-MHC Class I Antibody (W6/32) increases adherence of monocytes to human endothelial cells. Anti-MHC Class I Antibody (W6/32) can be used for the research of immunology .

HY-P990188

*Anti-Mouse MHC* class II (I-A) Antibody (Y-3P)**	MHC	Inflammation/Immunology
Anti-Mouse MHC class II (I-A) Antibody (Y-3P) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC class II. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) reacts with mouse MHC Class II haplotypes I-Ab, I-Af, I-Ap, I-Aq, I-Ar, I-As, I-Au, I-Av, and weakly with I-Ak. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) blocks MHC class II and inhibits expansion of regulate T cells. Anti-Mouse MHC class II (I-A) Antibody (Y-3P) can be used for the immunology research .

HY-P990193

*Anti-Mouse MHC* Class I (H-2Kd, H-2Dd) Antibody (34-1-2S)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) is an anti-mouse MHC Class I (H-2Kd, H-2Dd) IgG2a monoclonal antibody. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can block the interaction between Ly49 and MHC-I. Anti-Mouse MHC Class I (H-2Kd, H-2Dd) Antibody (34-1-2S) can be used for the construction of acute lung injury models .

HY-P99135

*Anti-Mouse MHC* Class I (H-2Kb) Antibody (Y-3)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) is a mouse-derived IgG2b antibody inhibitor, targeting to mouse MHC Class I (H-2Kb). Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) reacts with the mouse H-2Kb, H-2Kk, H-2Kq, H-2Kr, H-2ks MHC class I alloantigens and not H-2Kd. Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) can block MHC Class I. Anti-Mouse MHC Class I (H-2Kb) Antibody (Y-3) can be used for immunology research .

HY-P990185

*Anti-Mouse/Rat MHC* Class II (I-Ek/RT1-D) Antibody (14-4-4S)**	MHC	Inflammation/Immunology Cancer
Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse/rat MHC Class II. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) reacts with mouse MHC Class II alloantigen I-Ek and the rat MHC class II alloantigen RT1D. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) blocks antigen presentation. Anti-Mouse/Rat MHC Class II (I-Ek/RT1-D) Antibody (14-4-4S) can be used for the research of immunology and cancer .

HY-P990192

*Anti-Mouse MHC* Class I (H-2Kk) Antibody (AF3-12.1.3)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) is a mouse-derived IgG1 type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) reacts with the mouse H-2Kk MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kk) Antibody (AF3-12.1.3) can be used for the researches of inflammation and immunology, such as obliterative airway disease .

HY-P990061

Polzastobart JTX 8064	LILRB Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antagonist antibody that selectively binds LILRB2 and prevents it from binding its ligands, classical and non-classical MHC I molecules. Polzastobart enhances pro-inflammatory cytokine production in macrophages by blocking the ability of LILRB2 to bind HLA-A/B and/or HLA-G, a marker of immunotolerance on cancer cells. Polzastobart is a macrophage immune checkpoint inhibitor .

HY-P990194

*Anti-Mouse MHC* Class I (H-2Kd) Antibody (HB-159)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) reacts with the mouse H-2Kd MHC class I alloantigen. Anti-Mouse MHC Class I (H-2Kd) Antibody (HB-159) can be used for immunology research, such as cardiac graft .

HY-P990190

*Anti-Swine MHC* Class I (SLAd) Antibody (74-11-10)**	MHC	Others
Anti-Swine MHC Class I (SLAd) Antibody (74-11-10) is a mouse-derived IgG2b κ type antibody inhibitor, targeting to *Swine MHC* Class I*. Anti-Swine MHC* Class I (SLAd) Antibody (74-11-10) reacts with the swine leucocyte antigen (SLA) class I. Anti-Swine MHC Class I (SLAd) Antibody (74-11-10) can be used for the research of flow cytometry experiments .

HY-P990813

*Anti-Mouse Nonclassical MHC* Class I molecule Qa-1b Antibody (4C2.4A7.5H11)**	MHC	Cancer
Anti-Mouse Nonclassical MHC Class I molecule Qa-1b Antibody (4C2.4A7.5H11) is a mouse-derived IgG1 antibody inhibito, targeting to mouse *Nonclassical MHC* Class I molecule Qa-1b*. Anti-Mouse Nonclassical MHC* Class I molecule Qa-1b Antibody (4C2.4A7.5H11) reacts with the mouse non-classical MHC class I molecule Qa-1b. Anti-Mouse Nonclassical MHC Class I molecule Qa-1b Antibody (4C2.4A7.5H11) can be used for the research of cancer, such as B16F10 tumor .

HY-P990191

*Anti-Mouse MHC* Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13))**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse MHC Class I. Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) reacts with the mouse H-2Kk and H-2Dk MHC class I alloantigens. Anti-Mouse MHC Class I (H-2Kk, H-2Dk) Antibody (15-3-1S (HB-13)) can be used for immunology research .

HY-P990186

*Anti-Mouse MHC* Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2)**	MHC	Others
Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) is a mouse-derived IgG2c κ type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) reacts with mouse MHC Class II haplotypes I-Ak, I-Ar, I-Af, I-As, and I-Ag7. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) does not react with I-Ab, I-Ad, I-Ap, or I-Aq haplotypes. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) blocks MHC Class II and inhibits antigen proliferation responses. Anti-Mouse MHC Class II (I-Ak, I-Ar, I-Af, I-As,I-Ag7) Antibody (10-3.6.2) can be used for the research of immunology .

HY-P990184

*Anti-Mouse MHC* Class II (βchain) Antibody (KL277)**	MHC	Others
Anti-Mouse MHC Class II (βchain) Antibody (KL277) is a hamster/mouse-derived IgG type antibody inhibitor, targeting to mouse MHC Class II. Anti-Mouse MHC Class II (βchain) Antibody (KL277) reacts with mouse MHC Class II haplotypes I-Ab, I-Ad, I-Ap, I-Aq, I-Abu, and I-Abw. Anti-Mouse MHC Class II (βchain) Antibody (KL277) does not react with I-Aa, I-Ak, I-Af, I-Aj, I-As, or I-Atl haplotypes. Anti-Mouse MHC Class II (βchain) Antibody (KL277) can be used for western blot experiments .

HY-P990162

Anti-Mouse T15 VH and T15 VL regions of IgM Antibody (HB33) AB1-2	Inhibitory Antibodies	Others
Anti-Mouse T15 VH and T15 VL regions of IgM Antibody (HB33) is an anti-mouse T15 VH and T15 VL regions of IgM IgG1 monoclonal antibody. Anti-Mouse T15 VH and T15 VL regions of IgM Antibody (HB33) is used in studies of the MHC class I heavy chain FcRn heterodimers and their interaction with IgG .

HY-P990244

Anti-Rat FcRn heavy chain heterodimers Antibody (2G3)	Fc Receptor (FcR)	Inflammation/Immunology
Anti-Rat FcRn heavy chain heterodimers Antibody (2G3) is an anti-rat FcRn heavy chain heterodimers IgG1 monoclonal antibody. Anti-Rat FcRn heavy chain heterodimers Antibody (2G3) effectively inhibits the binding of FcRn to IgG. Anti-Rat FcRn heavy chain heterodimers Antibody (2G3) is used in studies of the MHC class I heavy chain FcRn heterodimers and their interaction with IgG .

HY-P991799

*Anti-Mouse MHC* Class I Antibody (A4C8.1-Do9)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I Antibody (A4C8.1-Do9) reacts with the mouse H-2Kb MHC class I alloantigen. MHC class I antigens are heterodimers consisting of one alpha chain (44 kDa) associated with β2 microglobulin (11.5 kDa). Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679) .

HY-P991806

*Anti-Mouse MHC* Class I (H-2Kb) Antibody (AF6-88.5)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kb) Antibody (AF6-88.5) reacts with the mouse H-2Kb MHC class I alloantigen. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) .

HY-P991786

*Anti-Mouse MHC* Class I (H-2Kb/H-2Db) Antibody**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Kb/H-2Db) Antibody (28-8-6S) reacts with the mouse H-2Kb and H-2Db MHC Class I alloantigens. Anti-Mouse MHC Class I (H-2Kb/H-2Db) Antibody (28-8-6S) can be used to study the role of H-2Kb and H-2Db alloantigens. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) .

HY-P991751

*Anti-Mouse MHC* Class I (H-2Db) Antibody (28-14-8S)**	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Db) Antibody (28-14-8S) reacts with the α3 domains of H-2Db of the MHC class I alloantigen expressed on nucleated cells from mice of the H-2Db haplotype. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) .

HY-P992353

ES009	LILRB	Cancer
ES009 is a high-affinity LILRB2 antagonist, with IC₅₀ values of 14.07 nM and 18.61 nM for inhibiting hLILRB2-huANGPTL3 and hLILRB2-huANGPTL4, respectively. ES009 specifically blocks the interactions between LILRB2 and MHC class I as well as non-MHC ligands, thereby effectively inhibiting receptor activation. ES009 can reprogram anti-inflammatory myeloid cells and induce their conversion to a pro-inflammatory phenotype, and also reverse the T cell suppression mediated by macrophages. When combined with anti-PD-1 blockade therapy, ES009 synergistically enhances T cell activation. ES009 can be used in research related to advanced solid tumors and ovarian cancer .

HY-P992388

IO-108	LILRB	Cancer
IO-108 is a humanized IgG4 monoclonal antibody and a competitive inhibitor of LILRB2, with a K_D value of 1.97 nM. IO-108 competitively blocks the binding of LILRB2 to its ligands including HLA-G, MHC-I, ANGPTL2 and SEMA4A, reprograms tumor-associated myeloid cells, drives the conversion of suppressive myeloid cells into a pro-inflammatory phenotype, and restores the cytotoxic activity of T cells and NK cells. IO-108 inhibits tumor growth in LILRB2 transgenic mouse models. IO-108 can be used for the research of solid tumors .

Species:	Human (42) Rhesus Macaque (1) Cynomolgus (4)
Tag:	SUMO (1) His (43) Avi (26) Fc (5)
Source:	HEK293 (40) P. pastoris (2) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P77769

	*HLA-A02:01&B2M&Survivin(LMLGEFLKL) Monomer Protein, Human (HEK293, His-Avi)** Survivin; MHC; MHC I; BIRC5; API4; EPR-1; IAP4; survivin variant 3 alpha	Human	HEK293

HY-P77770

	*HLA-A02:01&B2M&Survivin(LMLGEFLKL) Tetramer Protein, Human (HEK293, His-Avi)** Survivin; MHC; MHC I; BIRC5; API4; EPR-1; IAP4; survivin variant 3 alpha	Human	HEK293

HY-P700944

	*HLA-A02:01&B2M&Survivin(LMLGEFLKL) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** Survivin; MHC; MHC I; BIRC5; API4; EPR-1; IAP4; survivin variant 3 alpha	Human	HEK293

HY-P77753

	*HLA-A02:01&B2M&GP100(YLEPGPVTA) Monomer Protein, Human (HEK293, His-Avi)** HLA0201; MHC I; gp100; Glycoprotein 100; ME20-M; P100	Human	HEK293

HY-P77754

	*HLA-A02:01&B2M&GP100(YLEPGPVTA) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA0201; MHC I; gp100; Glycoprotein 100; ME20-M; P100	Human	HEK293

HY-P77750

	*HLA-A02:01&B2M&MAGE-A4(GVYDGREHTV) Monomer Protein, Human (HEK293, His-Avi)** HLA0201; MHC I; MAGE-A4; CT1.4; MAGE4A; MAGE4B; MAGE-X2; member 4	Human	HEK293

HY-P77752

	*HLA-A02:01&B2M&MAGE-A4(GVYDGREHTV) Tetramer Protein, Human (HEK293, His-Avi)** HLA0201; MHC I; MAGE-A4; CT1.4; MAGE4A; MAGE4B; MAGE-X2; member 4	Human	HEK293

HY-P77751

	*HLA-A02:01&B2M&MAGE-A4(GVYDGREHTV) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA0201; MHC I; MAGE-A4; CT1.4; MAGE4A; MAGE4B; MAGE-X2; member 4	Human	HEK293

HY-P700910

	*HLA-A24:02&B2M&GP100 Intron 4(VYFFLPDHL) Monomer Protein, Human (HEK293, His-Avi)** HLA-A24:02; HLA-A2402; MHC* I; gp100; Glycoprotein 100; ME20-M; P100; GP100 Intron 4; Intron 4	Human	HEK293

HY-P700909

	*HLA-A24:02&B2M&GP100 Intron 4(VYFFLPDHL) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA-A24:02; HLA-A2402; MHC* I; gp100; Glycoprotein 100; ME20-M; P100; GP100 Intron 4; Intron 4	Human	HEK293

HY-P71667

	HLA-G Protein, Human (HEK293, His) B2 microglobulin; DADB-15K14.8; HLA 6.0; HLA class I histocompatibility antigen alpha chain G; Major histocompatibility complex class I G; MHC class I antigen; MHC class I antigen G; MHC G; T-cell A locus; TCA	Human	HEK293
	HLA-G is a nonclassical major histocompatibility class Ib molecule that is critical for immune regulation at the maternal-fetal interface. It cooperates with B2M to form a complex that selectively binds self-peptides to promote maternal-fetal tolerance by interacting with KIR2DL4, LILRB1, and LILRB2 receptors. HLA-G Protein, Human (HEK293, His) is the recombinant human-derived HLA-G protein, expressed by HEK293 , with N-His labeled tag.

HY-P71699

	HLA-B Protein, Human (His) HLA-B protein; MHC class I antigen; HLA-B	Human	E. coli
	HLA-B Protein, a member of the major histocompatibility complex (MHC) class I family, is acknowledged. HLA-B Protein, Human (His) is the recombinant human-derived HLA-B protein, expressed by E. coli , with N-6*His labeled tag.

HY-P77758

	*HLA-E01:03&B2M&Peptide(VMAPRTLVL) Monomer Protein, Human (HEK293, His-Avi)** HLAE; sHLA-E; HLAE; MHC class I antigen E; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC; QA1	Human	HEK293

HY-P77760

	*HLA-E01:03&B2M&Peptide(VMAPRTLVL) Tetramer Protein, Human (HEK293, His-Avi)** HLAE; sHLA-E; HLAE; MHC class I antigen E; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC; QA1	Human	HEK293

HY-P77759

	*HLA-E01:03&B2M&Peptide(VMAPRTLVL) Monomer Protein, Human (Biotinylated, HEK293, His-Avi)** HLAE; sHLA-E; HLAE; MHC class I antigen E; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC; QA1	Human	HEK293

HY-P77761

	*HLA-E01:03&B2M&Peptide(VMAPRTLVL) Tetramer Protein, Human (Biotinylated, HEK293, His-Avi)** HLAE; sHLA-E; HLAE; MHC class I antigen E; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC; QA1	Human	HEK293

HY-P704845

	HLA-G Protein, Human (182a.a, His) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Human	E. coli

HY-P78455

	HLA-G Protein, Human (C66S, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Human	E. coli
	HLA-G is a nonclassical major histocompatibility class Ib molecule that is critical for immune regulation at the maternal-fetal interface. It cooperates with B2M to form a complex that selectively binds self-peptides to promote maternal-fetal tolerance by interacting with KIR2DL4, LILRB1, and LILRB2 receptors. HLA-G Protein, Human (C66S, His-Avi) is the recombinant human-derived HLA-G protein, expressed by E. coli , with C-Avi, C-His labeled tag and C66S, , , , mutation.

HY-P72227

	HLA-G Protein, Human (His-SUMO) B2 microglobulin; DADB-15K14.8; HLA 6.0; HLA class I histocompatibility antigen alpha chain G; HLA class I histocompatibility antigen; alpha chain G; HLA class I molecule; HLA G; HLA G antigen; HLA G histocompatibility antigen class I G; HLA G3; HLA-G; HLA-G histocompatibility antigen; class I; HLA60; HLAG; HLAG_HUMAN; Major histocompatibility complex class I G; MHC class I antigen; MHC class I antigen G; MHC G; T-cell A locus; TCA	Human	E. coli
	HLA-G is a nonclassical major histocompatibility class Ib molecule that is critical for immune regulation at the maternal-fetal interface. It cooperates with B2M to form a complex that selectively binds self-peptides to promote maternal-fetal tolerance by interacting with KIR2DL4, LILRB1, and LILRB2 receptors. HLA-G Protein, Human (His-SUMO) is the recombinant human-derived HLA-G protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P71700

	HLA-C Protein, Human (His) HLA class I histocompatibility antigen, C alpha chain; HLA-C protein; MHC class I antigen; HLA-Cw	Human	E. coli

HY-P77688

	HLA-G&B2M&Peptide (RIIPRHLQL) Monomer Protein, Human (HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Human	HEK293

HY-P77690

	HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer Protein, Human (HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Human	HEK293

HY-P77691

	HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer Protein, Human (Biotinylated, HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Human	HEK293

HY-P77687

	HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer Protein, Cynomolgus (HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Cynomolgus	HEK293

HY-P77689

	HLA-G&B2M&Peptide (RIIPRHLQL) Monomer Protein, Human (Biotinylated, HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Human	HEK293

HY-P77692

	HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer Protein, Rhesus Macaque (HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Rhesus Macaque	HEK293

HY-P700735

	HLA-G&B2M&Peptide (RIIPRHLQL) Monomer Protein, Cynomolgus (HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Cynomolgus	HEK293

HY-P73294

	MICB Protein, Human (HEK293, His) MHC class I polypeptide-related sequence B; MIC-B; PERB11.2	Human	HEK293
	MICB Protein, a heavily glycosylated ligand for NKG2D receptor, triggers cytolytic response in immune cells. It resembles MHC class I molecules but lacks association with beta-2-microglobulin or peptide binding. Alternative splicing leads to multiple transcript variants. MICB is widely expressed, especially in lymph nodes and bone marrow, highlighting its immune response role in diverse physiological contexts. MICB Protein, Human (HEK293, His) is the recombinant human-derived MICB protein, expressed by HEK293 , with C-His, C-6*His labeled tag.

HY-P75928

	MICA Protein, Cynomolgus (HEK293, His) MHC class I polypeptide-related sequence A; MIC-A; PERB11.1	Cynomolgus	HEK293
	MICA Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived MICA, expressed by HEK293 , with C-His labeled tag. ,

HY-P701002

	PE-Labeled HLA-G&B2M&Peptide (RIIPRHLQL) Tetramer Protein, Human (HEK293, His-Avi) HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Human	HEK293

HY-P70579

	MICA Protein, Human (HEK293, Fc) MHC Class I Polypeptide-Related Sequence A; MIC-A; MICA; PERB11.1	Human	HEK293
	MICA is a ligand for the stress signaling protein and natural killer (NK) cell activating receptor KLRK1/NKG2D. Tumor cells shed the expressed MICA protein and undergo immune evasion. MICA Protein, Human (HEK293, Fc) is the recombinant human-derived MICA protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73293

	MICB Protein, Human (HEK293, His-Fc) MHC class I polypeptide-related sequence B; MIC-B; PERB11.2	Human	HEK293
	In contrast to antigen presentation, MICB proteins serve as stress-induced autoantigens and are recognized by γδ T cells. As a ligand for the KLRK1/NKG2D receptor, binding of MICB results in cell lysis. MICB Protein, Human (HEK293, His-Fc) is the recombinant human-derived MICB protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

HY-P70157

	MICA Protein, Human (HEK293, His) rHuMHC class I polypeptide-related sequence A/MICA, His ; MHC Class I Polypeptide-Related Sequence A; MIC-A; MICA; PERB11.1	Human	HEK293
	MICA is a ligand for the stress signaling protein and natural killer (NK) cell activating receptor KLRK1/NKG2D. Tumor cells shed the expressed MICA protein and undergo immune evasion. MICA Protein, Human (HEK293, His) is the recombinant human-derived MICA protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P704789

	MICB Protein, Human (286a.a, HEK293, His) MHC class I polypeptide-related sequence B; MIC-B; PERB11.2	Human	HEK293
	MICB Protein, Human (286a.a, HEK293, His) is the recombinant human-derived MICB protein, expressed by HEK293, with C-His tag.

HY-P704788

	MICA Protein, Human (HEK293, IgG4 Fc) rHuMHC class I polypeptide-related sequence A/MICA, His ; MHC Class I Polypeptide-Related Sequence A; MIC-A; MICA; PERB11.1	Human	HEK293
	MICA Protein, Human (HEK293, IgG4 Fc) is the recombinant human-derived MICA protein, expressed by HEK293, with C-hFc tag.

HY-P704964

	MICA Protein, Human (179a.a, HEK293, mFc) MHC Class I Polypeptide-Related Sequence A; MIC-A; MICA; PERB11.1	Human	HEK293

HY-P704225

	MICA Protein, Human (179a.a, HEK293, His) MHC Class I Polypeptide-Related Sequence A; L MIC-A; L MICA; L PERB11.1	Human	HEK293
	MICA protein is recognized by γδ T cells as a stress-induced autoantigen independent of antigen presentation. As a ligand for the KLRK1/NKG2D receptor, MICA binding triggers cell lysis. MICA Protein, Human (179a.a, HEK293, His) is the recombinant human-derived MICA protein, expressed by HEK293, with C-His labeled tag.

HY-P705394

	MR1-B2M Complex Protein, Human (Biotinylated, HEK293, His-Avi) MR1 & B2M; Major histocompatibility complex class I-related protein 1; MR1; MHC class I-related protein 1; Class I histocompatibility antigen-like protein; MR1	Human	HEK293

HY-P7807

	CRTAM/CD355 Protein, Cynomolgus (HEK293, His) rCynCRTAM, His; Cytotoxic and Regulatory T-Cell Molecule; Class-I MHC-Restricted T-Cell-Associated Molecule; CD355; CRTAM	Cynomolgus	HEK293
	CRTAM/CD355 Protein is an immunoglobulin-superfamily transmembrane protein, and is a member of nectin-like protein superfamily. CRTAM is also expressed on activated human NK cells, CD8+ T cells and a subset of CD4+ T cells. CRTAM takes part in cellular adhesion, polarity, and proliferation. CRTAM also regulates lymphocyte function, and promotes TCD8+ cell adhesion and retention within the lymph node. Furthermore, CRTAM can interact with Necl-2, and promotes cytotoxicity of NK cells and IFN-γ secretion of CD8+ T cells in vitro, and NK cell-mediated rejection of tumors expressing Necl-2 in vivosup>[3]. CRTAM/CD355 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CRTAM/CD355 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71823

	KIR2DS1 Protein, Human (P.pastoris, His) KIR2DS1; CD158 antigen-like family member H; MHC class I NK cell receptor Eb6 ActI	Human	P. pastoris
	KIR2DS1, on NK cells, acts as a receptor for specific HLA-C alleles, like w6, without inhibiting NK cell activity. Interacting with the adapter protein TYROBP/DAP12, their collaboration enhances KIR2DS1 stability at the cell surface. This dynamic interplay highlights the intricate regulatory mechanisms associated with KIR2DS1, contributing to the modulation of NK cell responses. KIR2DS1 Protein, Human (P.pastoris, His) is the recombinant human-derived KIR2DS1 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P7855

	CRTAM/CD355 Protein, Human (HEK293, His) rHuCytotoxic and regulatory T-cell molecule/CRTAM, His; Cytotoxic and Regulatory T-Cell Molecule; Class-I MHC-Restricted T-Cell-Associated Molecule; CD355; CRTAM	Human	HEK293
	The CRTAM/CD355 protein is a key mediator of heterophilic intercellular adhesion and complexly regulates the activation, differentiation, and tissue retention of T cell subsets. Its interaction with CADM1 promotes NK cell cytotoxicity and CD8+ T cell secretion of IFNG, thus contributing to NK cell-mediated tumor rejection. CRTAM/CD355 Protein, Human (HEK293, His) is the recombinant human-derived CRTAM/CD355 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71815

	KIR2DS3 Protein, Human (P.pastoris, His) KIR2DS3; NKAT7Killer cell immunoglobulin-like receptor 2DS3; MHC class I NK cell receptor; Natural killer-associated transcript 7; NKAT-7	Human	P. pastoris
	KIR2DS3, present on NK cells, selectively recognizes HLA-C alleles. In contrast to inhibitory KIRs, KIR2DS3 lacks inhibitory effects on NK cell activity. Its role is likely in activating or modulating NK cell functions, contributing to the nuanced balance of signals regulating the immune response. KIR2DS3 Protein, Human (P.pastoris, His) is the recombinant human-derived KIR2DS3 protein, expressed by P. pastoris , with N-His labeled tag.

HY-P7794

	CD158d/KIR2DL4 Protein, Human (HEK293, His) rHuCD158d, His; Killer Cell Immunoglobulin-Like Receptor 2DL4; CD158 Antigen-Like Family Member D; KIR-103AS; MHC Class I NK Cell Receptor KIR103AS; CD158d; KIR2DL4; KIR103AS	Human	HEK293
	CD158d/KIR2DL4 Protein, Human (HEK293, His) is a recombinant human CD158d expressed in HEK 293 cells with a His tag at the N-terminus. CD158d/KIR2DL4 Protein is an NK cell-activating receptor with inhibitory potential.

HY-P77970

	KIR2DL2/CD158b1 Protein, Human (HEK293, His-Avi) Killer cell immunoglobulin-like receptor 2DL2; CD158 antigen-like family member B1; MHC class I NK cell receptor; NKAT-6; p58 NK receptor CL-43; CD158b1; KIR2DL2; CD158B1; NKAT6	Human	HEK293
	KIR2DL2/CD158b1, found on NK cells, functions as a receptor for HLA-Cw1, Cw3, Cw7, and Cw8 allotypes. Its key role is to inhibit NK cell activity, serving as a regulator to prevent cellular lysis. Interacting with specific HLA-C molecules, KIR2DL2/CD158b1 contributes to the delicate balance of inhibitory signals in the immune system, shaping the responsiveness of NK cells to potential targets. KIR2DL2/CD158b1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived KIR2DL2/CD158b1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P77971

	KIR2DL2/CD158b1 Protein, Human (Biotinylated, HEK293, His-Avi) Killer cell immunoglobulin-like receptor 2DL2; CD158 antigen-like family member B1; MHC class I NK cell receptor; NKAT-6; p58 NK receptor CL-43; CD158b1; KIR2DL2; CD158B1; NKAT6	Human	HEK293
	KIR2DL2/CD158b1, found on NK cells, functions as a receptor for HLA-Cw1, Cw3, Cw7, and Cw8 allotypes. Its key role is to inhibit NK cell activity, serving as a regulator to prevent cellular lysis. Interacting with specific HLA-C molecules, KIR2DL2/CD158b1 contributes to the delicate balance of inhibitory signals in the immune system, shaping the responsiveness of NK cells to potential targets. KIR2DL2/CD158b1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived KIR2DL2/CD158b1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P704733

	KIR2DL2/CD158b1 Protein, Human (HEK293, Fc) Killer cell immunoglobulin-like receptor 2DL2; CD158 antigen-like family member B1; MHC class I NK cell receptor; NKAT-6; p58 NK receptor CL-43; CD158b1; KIR2DL2; CD158B1; NKAT6	Human	HEK293
	KIR2DL2/CD158b1, found on NK cells, functions as a receptor for HLA-Cw1, Cw3, Cw7, and Cw8 allotypes. Its key role is to inhibit NK cell activity, serving as a regulator to prevent cellular lysis. Interacting with specific HLA-C molecules, KIR2DL2/CD158b1 contributes to the delicate balance of inhibitory signals in the immune system, shaping the responsiveness of NK cells to potential targets. KIR2DL2/CD158b1 Protein, Human (HEK293, Fc) is the recombinant human-derived KIR2DL2/CD158b1 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P70354

	KIR2DL3 Protein, Human (HEK293, His) rHuKiller cell immunoglobulin-like receptor 2DL3/KIR2DL3, His; Killer Cell Immunoglobulin-Like Receptor 2DL3; CD158 Antigen-Like Family Member B2; KIR-023GB; Killer Inhibitory Receptor cl 2-3; MHC Class I NK Cell Receptor; NKAT2a; NKAT2b; Natural Killer-Associated Transcript 2; NKAT-2; p58 Natural Killer Cell Receptor Clone C	Human	HEK293
	KIR2DL3, found on NK cells, selectively recognizes HLA-C alleles like HLA-Cw1, HLA-Cw3, and HLA-Cw7. Its interaction leads to inhibitory effects, preventing NK cell activity and cell lysis. KIR2DL3's association with ARRB2 underscores its role in cellular signaling pathways, intricately modulating NK cell functions. KIR2DL3 Protein, Human (HEK293, His) is the recombinant human-derived KIR2DL3 protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-126855S

Cholic acid 7-sulfate-d4

Cholic acid 7-sulfate-d₄ (7-Sulfocholic acid-d₄) is the deuterium labeled Cholic acid 7-sulfate (HY-126855). Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC₅₀=0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation .

Host:	Mouse (4) Rabbit (10)
Reactivity:	Human (14) mouse (1) Rat (1) Mouse (1)
Application:	IHC-P (6) ICC/IF (3) IP (4) WB (10) FC (5) WB ICC/IF (1)
Isotype:	IgG (12) IgG1 (2)
Conjugation:	Non-conjugated (14) Biotin (10)
Clonality:	Monoclonal (10) Recombinant (8)
Modification:	Unmodified (10)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810464

	HLA G Antibody (YA9763) HLA-G, Major Histocompatibility Complex, Class I, G, HLA Class I Histocompatibility Antigen, Alpha Chain G, HLA-G Histocompatibility Antigen, Class I, G, MHC Class I Antigen G, B2 Microglobulin, HLA G Antigen, Mutant MHC Class Ib Antigen, Mutant MHC Class I Antigen, MHC Class Ib Antigen, MHC Class I Protein, HLA-6.0, MHC-G, HLAG	WB ICC/IF	Human, mouse
	HLA G Antibody (YA9763) is a Rabbit-derived and non-conjugated IgG Monoclonal, Recombinant antibody, targeting to HLA G.

HY-P83577

	MHC Class I Antibody (YA3322) Aw-68; HLA class I histocompatibility antigen; A-28 alpha chain; MHC class I antigen A68; HLA-A; MHC* class I antigen HLA A heavy chain	WB, IHC-P	Human
	MHC Class I Antibody (YA3322) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MHC Class I.

HY-P83577A

	MHC Class I Antibody (YA3322)(PBS only) Aw-68; HLA class I histocompatibility antigen; A-28 alpha chain; MHC class I antigen A68; HLA-A; MHC* class I antigen HLA A heavy chain	WB, IHC-P	Human
	MHC Class I Antibody (YA3322) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MHC Class I.

HY-P83195

	HLA Class 1 A Antibody (YA2940) Aw-68; HLA class I histocompatibility antigen; A-28 alpha chain; MHC class I antigen A68; HLA-A; MHC* class I antigen HLA A heavy chain	WB, IHC-P, ICC/IF, IP, FC	Human
	HLA Class 1 A Antibody (YA2940) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HLA Class 1 A.

HY-P84941

	HLA Class 1 ABC Antibody (YA4638) Antigen Presenting Molecule antibody; Cw1701 antibody; D6S204 antibody; FLJ27082 antibody; HLA A antibody; HLA B antibody; HLA C antibody; HLA class 1 A antibody; HLA class 1 B antibody; HLA class 1 C antibody; HLA JY3 antibody; HLAA antibody; HLAB antibody; HLAC antibody; HLC C antibody; Human Leucocyte Antigen C antibody; Major Histocompatibility Complex Class I A antibody; Major Histocompatibility Complex Class I B antibody; Major Histocompatibility Complex Class I C antibody; Major histocompatibility complex, class I, A + B + C antibody; MHC* class I antigen A1 antibody; MHC* Class I Antigen antibody; MHC class I antigen B7 antibody; MHC* class I antigen Cw1 antibody; MHC* class I HLA A antibody; MHC class I HLA B antibody; MHC class I HLA C antibody; MHC HLA ABC antibody; PSORS1 antibody	ICC/IF, FC	Human
	HLA Class 1 ABC Antibody (YA4638) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HLA Class 1 ABC.

HY-P83701

	HLA E Antibody (YA3437) HLA class I histocompatibility antigen E alpha chain antibody; EA1.2 antibody; EA2.1 antibody; HLA 6.2 antibody; HLA class I histocompatibility antigen alpha chain E antibody; HLA class I histocompatibility antigen E alpha chain precursor antibody; HLA class I histocompatibility antigen E alpha chain precursor antibody; HLA6.2 antibody; HLAE antibody; Lymphocyte antigen antibody; Major histocompatibility complex class I E antibody; MHC antibody; MHC class I antigen E antibody; MHC HLA E alpha 1 antibody; MHC HLA E alpha 2.1 antibody; QA1 antibody;	WB, IP, FC	Human
	HLA E Antibody (YA3437) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HLA E.

HY-P83480

	HLA G Antibody (YA3225) HLA G antigen; MHC class I antigen G; HLA-G; HLA60; HLAG	WB	Human
	HLA G Antibody (YA3225) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HLA G.

HY-P83760

	MICA+MICB Antibody (YA3560) HLA class I antigen antibody; FLJ36918 antibody; FLJ60820 antibody; MGC111087 antibody; MGC21250 antibody; MHC class I chain related gene A protein antibody; MIC A antibody; micA antibody; MICA_HUMAN antibody; OTTHUMP00000029088 antibody; PERB11.1 antibody; Stress inducible class I homolog antibody; MHC class I chain related protein B antibody; MICB antibody MICB_HUMAN antibody PERB11.2 antibody Stress inducible class I homolog antibody	WB, IP, FC	Human
	MICA+MICB Antibody (YA3560) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MICA+MICB.

HY-P81719

	MICA Antibody (YA1464) PERB11.1; MICA; HLA class I antigen antibody; FLJ36918 antibody; FLJ60820 antibody; MGC111087 antibody; MGC21250 antibody; MHC class I chain related gene A protein antibody	WB, IP, FC	Human
	MICA Antibody (YA1464) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MICA.

HY-P86752

	beta 2 Microglobulin Antibody (YA6444) B2M; beta 2 microglobulin precursor; beta-2 Microglobulin; beta chain of MHC class 1 proteins; Hdcma22p; B2MG_HUMAN; beta 2 microglobin; beta 2 microglobulin precursor; beta chain of MHC class 1 proteins; beta chain of MHC class I molecules; beta-2-microglobulin form pI 5.3; CDABP0092.	WB	Human
	beta 2 Microglobulin Antibody (YA6444) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to beta 2 Microglobulin.

HY-P86752A

	beta 2 Microglobulin Antibody (YA6444)(PBS only) B2M; beta 2 microglobulin precursor; beta-2 Microglobulin; beta chain of MHC class 1 proteins; Hdcma22p; B2MG_HUMAN; beta 2 microglobin; beta 2 microglobulin precursor; beta chain of MHC class 1 proteins; beta chain of MHC class I molecules; beta-2-microglobulin form pI 5.3; CDABP0092.	WB	Human
	beta 2 Microglobulin Antibody (YA6444) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to beta 2 Microglobulin.

HY-P87060

	Retinoid X Receptor beta/RXRB Antibody (YA6753) DAUD I6 antibody; DAUDI6 antibody; H 2RIIBP antibody; H2RIIBP antibody; MGC1831 antibody; MHC class I promoter binding protein antibody; NR2B2 antibody; Nuclear receptor subfamily 2 group B member 2 antibody; RCoR 1 antibody; RCoR1 antibody; DAUD I6 antibody; DAUDI6 antibody; H 2RIIBP antibody; H2RIIBP antibody; MGC1831 antibody; MHC class I promoter binding protein antibody; NR2B2 antibody; Nuclear receptor subfamily 2 group B member 2 antibody; RCoR 1 antibody; RCoR1 antibody; Retinoic acid receptor RXR beta antibody; Retinoic acid receptor RXR-beta antibody; Retinoid X receptor beta antibody; RXR beta antibody; Rxrb antibody; RXRB_HUMAN antibody; RXRbeta antibody;	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Retinoid X Receptor beta/RXRB Antibody (YA6753) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Retinoid X Receptor beta/RXRB.

HY-P81501

	KIR2DL3 Antibody (YA1246) KIR2DL3 ; CD158B2, KIRCL23, NKAT2; CD158b2; Killer cell immunoglobulin-like receptor 2DL3 ; CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; NKAT2a; NKAT2b; Natural killer-associated transcript 2 (NKAT-2); p58 natural killer cell receptor clone CL-6 (p58 NK receptor CL-6); p58.2 MHC class-I-specific NK receptor	IHC-P	Human
	KIR2DL3 Antibody (YA1246) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KIR2DL3.

HY-P81501A

	KIR2DL3 Antibody (YA1246)(PBS only) KIR2DL3 ; CD158B2, KIRCL23, NKAT2; CD158b2; Killer cell immunoglobulin-like receptor 2DL3 ; CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; NKAT2a; NKAT2b; Natural killer-associated transcript 2 (NKAT-2); p58 natural killer cell receptor clone CL-6 (p58 NK receptor CL-6); p58.2 MHC class-I-specific NK receptor	IHC-P	Human
	KIR2DL3 Antibody (YA1246) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KIR2DL3.

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