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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
Maytansine
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "Maytansine" in MCE Product Catalog:
Synonyms: NSC 153858
Category:
Alkaloids Other Alkaloids Celastraceae Plants Maytenus hookeri Loes. Disease Research Fields Cancer
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Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC) .
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7 Cited Publications
Cat. No.: HY-P9921A
CAS No.: 1018448-65-1
Synonyms: Ado-Trastuzumab emtansine (solution); PRO132365 (solution); T-DM 1 (solution)
Cat. No.: HY-19474
CAS No.: 57103-68-1
Synonyms: Ansamitocin P-0
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Synonyms: Maytansinoid DM3
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DM3 (Maytansinoid DM3), a Maytansine (HY-13674) analog bearing disulfide or thiol groups, and is a tubulin inhibitor. DM3 a cytotoxic moiety of antibody-drug conjugates (ADCs) .
Cat. No.: HY-P99492
CAS No.: 400010-39-1
Synonyms: SB-408075; huC242-DM1
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Cat. No.: HY-136261
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DM1-(PEG)4-DBCO is a drug-linker conjugate composed of the tubulin inhibitor DM1 (HY-19792) and the linker DBCO-PEG4-Ahx. DM1 is a tubulin inhibitor and an antibody-conjugated maytansinoid; it was developed to overcome the systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DM1-PEG4-DBCO is a click chemistry reagent.
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S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 μM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects .
Cat. No.: HY-W074975
CAS No.: 14949-00-9
Synonyms: 5-Amino-1,3,4-thiadiazole-2-sulfonamide
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CL 5343 (5-Amino-1,3,4-thiadiazole-2-sulfonamide) is a selective inhibitor of carbonic anhydrase B (HCA-B) and isoforms I, II, IV, and VII. CL 5343 has a Ki of 7.9 nM for hCA II. CL 5343 acts as a CA9 ligand to achieve targeted delivery of maytansine to the cell membrane of SKRC52 renal cancer cells. CL 5343 is useful in the development of therapeutics for diseases associated with CA overactivity, such as glaucoma, epilepsy, and cancer .
Cat. No.: HY-P991661
CAS No.: 1607838-85-6
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Cat. No.: HY-156897
Purity: 98.01%
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Val-Cit-amide-Ph-Maytansine is an antibody and bispecific antigen-binding mol. that bind hepatocyte growth factor receptor c-Met (MET) or antibody-drug conjugates (ADCs) .
Cat. No.: HY-100503
CAS No.: 799840-96-3
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Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC .
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DBCO-PEG4-Ahx-DM1 is a agent-linker conjugate composed of a potent microtubulin inhibitor DM1 and a linker DBCO-PEG4-Ahx to make antibody agent conjugate (ADC). Mertansine (DM1) is a microtubulin inhibitor and is an antibody-conjugatable maytansinoid that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. DBCO-PEG4-Ahx-DM1 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Cat. No.: HY-143987
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DM51 impurity 1 is a natural product related to Maytansine (HY-13674) .
Cat. No.: HY-130081
CAS No.: 796073-70-6
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DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM .
Cat. No.: HY-171125
CAS No.: 2226467-81-6
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Maytansine derivative M24 is an ADC Drug-Linker Conjugates for ADC that can be used to synthesize ADC REGN5093-M114 .
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Val-Cit-amide-Cbz-N(Me)-Maytansine is an antibody and bispecific antigen-binding mol. that bind hepatocyte growth factor receptor c-Met (MET) or antibody-drug conjugates (ADCs) .
Cat. No.: HY-19474R
CAS No.: 57103-68-1
Synonyms: Ansamitocin P-0 (Standard)
Category:
Cat. No.: HY-19792S2
Synonyms: DM1-d3; Maytansinoid DM1-d3
Cat. No.: HY-19792S
Synonyms: DM1-13C,d3; Maytansinoid DM1-13C,d3
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
