796073-54-6
Chemical Structure
DM3
Synonym(s): Maytansinoid DM3
- CAS No.: 796073-54-6
- Formula:C37H52ClN3O10S
- Molecular Weight:766.34
IUPAC Name: (14S,16S,32S,33S,2R,4S,10E,12E,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-(4-mercaptopentanoyl)-N-methyl-L-alaninate
InChIKey: LJFFDOBFKICLHN-IXWHRVGISA-N
SMILES: C[C@]12[C@H]([C@@H]([C@](O3)([H])C[C@]([C@](/C=C/C=C(C)/CC4=CC(N(C)C(C[C@]2([H])OC([C@H](C)N(C)C(CCC(S)C)=O)=O)=O)=C(C(OC)=C4)Cl)([H])OC)(NC3=O)O)C)O1
Biological Activity: DM3 (Maytansinoid DM3), a Maytansine (HY-13674) analog bearing disulfide or thiol groups, and is a tubulin inhibitor. DM3 a cytotoxic moiety of antibody-drug conjugates (ADCs)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DM3 | 95.59% | DM3 (Maytansinoid DM3), a Maytansine (HY-13674) analog bearing disulfide or thiol groups, and is a tubulin inhibitor. DM3 a cytotoxic moiety of antibody-drug conjugates (ADCs). | ||||||||||||||||||||
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- [1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). [Content Brief]
- [2]. Griffin P, et al. High anti-tumor activity of a novel alpha-fetoprotein-maytansinoid conjugate targeting alpha-fetoprotein receptors in colorectal cancer xenograft model. Cancer Cell Int. 2023 Apr 5;23(1):60. [Content Brief]
Keywords
