6 Results for "

Mycobacterium tuberculosis ClpC1

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "Mycobacterium tuberculosis ClpC1" in MCE Product Catalog:

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Cat. No.: HY-P11498
Research Areas:  

Infection

Cyclomarin monomer-2 (Compound 10), a cyclomarin monomer, is a pre-dimerization precursor that can form Homo-BacPROTACs targeting the degradation of ClpC1. Cyclomarin monomer-2 binds to the Mtb ClpC1 protein with a KD of 4.0 nM. The MIC of Cyclomarin monomer-2 against the Mtb H37Rv standard strain is 3.1 μM. Cyclomarin monomer-2 can be used as a key intermediate in the development of Homo-BacPROTACs .
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Cat. No.: HY-P11497
Research Areas:  

Infection

Cyclomarin monomer-1 (Compound 5), a cyclomarin monomer, is a pre-dimerization precursor that can form Homo-BacPROTACs targeting the degradation of ClpC1. Cyclomarin monomer-1 binds to the Mtb ClpC1 protein with a KD of 3.5 nM. The MIC of Cyclomarin monomer-1 against the Mtb H37Rv standard strain is 1.6 μM. Cyclomarin monomer-1 can be used as a key intermediate in the development of Homo-BacPROTACs .
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Cat. No.: HY-P701867
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Rv3596c; MTCY07H7B.26; ClpC1; ATP-dependent Clp protease ATP-binding subunit ClpC1
Species:  
Others
Source:  
E. coli
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Cat. No.: HY-P701868
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Rv3596c; MTCY07H7B.26; ClpC1; ATP-dependent Clp protease ATP-binding subunit ClpC1
Species:  
Others
Source:  
E. coli
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Cat. No.: HY-P6300
CAS No.: 169062-92-4
Target:  

Bacterial Parasite

Research Areas:  

Infection

Cyclomarin A is an antibacterial agent with a Kd of 2.3 nM against Mycobacterium tuberculosis ClpC1, a Kd of 2.2 nM against ClpC2, and an IC50 of 0.004 μM against Plasmodium falciparum PfAp3Aase. Cyclomarin A binds to the N-terminal domain of ClpC1, stimulates ATPase and proteolytic activities, dysregulates proteolysis, and induces proteome imbalance; it also binds to ClpC2 and upregulates its transcription level. Cyclomarin A binds to PfAp3Aase in dimeric form, blocks the substrate-binding pathway, inhibits the growth of Plasmodium falciparum in the erythrocytic stage, and shows no activity against human cells. Cyclomarin A exhibits moderate cytotoxicity against a variety of cancer cell lines. Cyclomarin A can serve as a lead compound for the development of Homo-BacPROTAC. Cyclomarin A is applicable to research related to tuberculosis and malaria .
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Cat. No.: HY-153573
Synonyms: dCym-JQ1
Research Areas:  

Infection

SRG-II-19F (dCym-JQ1) is a BRDTBD1 PROTAC degrader. Its dCym moiety at one end binds to the N-terminal domain of ClpC1 (ClpC1NTD), while its JQ1 moiety at the other end binds to bromodomain 1 of BRDT (BRDTBD1). This molecule induces the degradation of BRDTBD1 by recruiting the BRDTBD1 substrate to the ClpC1P1P2 protease complex. SRG-II-19F serves as a research tool for studies related to mycobacterial protein degradation .
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