Cyclomarin monomer-2

Cat. No.: HY-P11498 Purity: 97.40%: Data Sheet
COA

SDS
Handling Instructions
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Cyclomarin monomer-2 (Compound 10), a cyclomarin monomer, is a pre-dimerization precursor that can form Homo-BacPROTACs targeting the degradation of ClpC1. Cyclomarin monomer-2 binds to the Mtb ClpC1 protein with a K_D of 4.0 nM. The MIC of Cyclomarin monomer-2 against the Mtb H37Rv standard strain is 3.1 μM. Cyclomarin monomer-2 can be used as a key intermediate in the development of Homo-BacPROTACs.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclomarin monomer-2 Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

913.11

Formula

C₄₉H₆₈N₈O₉

Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (109.52 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0952 mL	5.4758 mL	10.9516 mL
5 mM	0.2190 mL	1.0952 mL	2.1903 mL
10 mM	0.1095 mL	0.5476 mL	1.0952 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.49%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (262 KB) RP-HPLC (429 KB) LCMS (113 KB)

Handling Instructions (2659 KB)

References

[1]. Junk L, et al. Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria. Nat Commun. 2024 Mar 5;15(1):2005 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0952 mL	5.4758 mL	10.9516 mL	27.3790 mL
	5 mM	0.2190 mL	1.0952 mL	2.1903 mL	5.4758 mL
	10 mM	0.1095 mL	0.5476 mL	1.0952 mL	2.7379 mL
	15 mM	0.0730 mL	0.3651 mL	0.7301 mL	1.8253 mL
	20 mM	0.0548 mL	0.2738 mL	0.5476 mL	1.3689 mL
	25 mM	0.0438 mL	0.2190 mL	0.4381 mL	1.0952 mL
	30 mM	0.0365 mL	0.1825 mL	0.3651 mL	0.9126 mL
	40 mM	0.0274 mL	0.1369 mL	0.2738 mL	0.6845 mL
	50 mM	0.0219 mL	0.1095 mL	0.2190 mL	0.5476 mL
	60 mM	0.0183 mL	0.0913 mL	0.1825 mL	0.4563 mL
	80 mM	0.0137 mL	0.0684 mL	0.1369 mL	0.3422 mL
	100 mM	0.0110 mL	0.0548 mL	0.1095 mL	0.2738 mL