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N-oxidation

" in MedChemExpress (MCE) Product Catalog:

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Oligonucleotides:	Cationic Lipids (1)

228

Inhibitors & Agonists

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Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116084

Trimethylamine N-oxide Maximum Cited Publications 11 Publications Verification	Drug Metabolite NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-116084S

*Trimethylamine N-oxide-d9* 1 Publications Verification	NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Trimethylamine N-oxide-d₉ is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-Y1101B

4-Methylmorpholine N-oxide N-Methylmorpholine N-Oxide; MMNO; 4-Methylmorpholine 4-oxide	Biochemical Assay Reagents	Others
4-Methylmorpholine N-oxide (N-Methylmorpholine N-Oxide; MMNO; 4-Methylmorpholine 4-oxide) is an amine oxide ligand and ozonation reagent. 4-Methylmorpholine N-oxide forms coordination complexes with lanthanum (III) nitrate and yttrium (III) nitrate via its nitroso oxygen atom. The metal-ligand bonds are dominated by electrostatic interactions with a small covalent component. 4-Methylmorpholine N-oxide is applicable in ozonation reactions for the synthesis of methyl 9-oxononanoate .

HY-108915

*Trimethylamine N-oxide* dihydrate** Maximum Cited Publications 11 Publications Verification	NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide dihydrate induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide dihydrate also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-125785A

*2-Mercaptopyridine N-oxide* sodium**	Bacterial	Infection
2-Mercaptopyridine N-oxide sodium has bactericidal effect and is against a standard strain of Mycobacterium tuberculosis H37Rv (ATCC 27294) with MIC₉₀ of 7.20 μM. 2-Mercaptopyridine N-oxide sodium and its complex with iron, gallium, and bismuth have good anti-M. tuberculosis activity. 2-Mercaptopyridine N-oxide sodium has potential for the treatment of tuberculosis .

HY-124098

Lignocaine N-oxide Lidocaine N-oxide	Drug Metabolite	Others
Lignocaine N-oxide (Lidocaine N-oxide) is a compound derived from the metabolism of lidocaine. Lidocaine can be metabolized to its N-oxide in rat liver microsomes.

HY-142122

Imipramine N-oxide	Drug Metabolite	Neurological Disease
Imipramine N-oxide is the metabolite of Imipramine. Imipramine N-oxide exhibits low toxicity in rat and mouse experiments. Imipramine N-oxide can be used for the research of endogenous depressions .

HY-N1402

Oxysophoridine Sophoridine N-oxide	Apoptosis	Inflammation/Immunology
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects .

HY-119393

Olanzapine N-oxide	Drug Metabolite	Others
Olanzapine N-oxide is a compound under investigation for the metabolism of antipsychotic compounds. Olanzapine N-oxidation and N-demethylation are catalyzed by different enzymes, and its plasma concentration and clearance are not affected by a single factor, such as a specific genotype or smoking behavior.

HY-W145090

4-Dimethylaminopyridine N-oxide p-Dimethylaminopyridine N-oxide	Biochemical Assay Reagents	Others
4-Dimethylaminopyridine N-oxide (p-Dimethylaminopyridine N-oxide) is an Efficient Oxidizing Agent for Alkyl Halides .

HY-17366R

*Clozapine N-oxide* (Standard)**	Reference Standards mAChR Dopamine Receptor Drug Metabolite	Neurological Disease
Clozapine N-oxide (Standard) is the analytical standard of Clozapine N-oxide. This product is intended for research and analytical applications. Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide cannot cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].

HY-137989A

*Voriconazole N-oxide* hydrochloride** Voriconazole oxynitride hydrochloride	Drug Metabolite	Infection
Voriconazole N-oxide (Voriconazole oxynitride) (hydrochloride) is the main metabolite of Voriconazole (HY-76200) , a widely used triazole antibiotic (fungal). Voriconazole N-oxide (hydrochloride) provides information on the patient's drug metabolism capacity .

HY-N6637S

*Senecionine N-oxide-d3*	Isotope-Labeled Compounds	Cancer
Senecionine N-oxide-d₃ is the deuterium labeled Senecionine N-oxide. Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity .

HY-116084S1

*Trimethylamine-N-oxide-13C3*	Isotope-Labeled Compounds NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Trimethylamine-N-oxide- ¹³C₃ is the ¹³C-labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-N11425

Benzydamine N-Oxide	Others	Others
Benzydamine N-Oxide is a metabolite of Benzydamine. Benzydamine N-Oxide can be used to measure flavin-containing monooxygenase activity .

HY-133798

Sorafenib N-oxide	Cytochrome P450 Drug Metabolite	Cancer
Sorafenib N-oxide is an active metabolite of sorafenib (HY-10201). Sorafenib N-oxide is a linear-mixed inhibitor of microsomal CYP3A4, with a K_i of 15 μM .

HY-100639R

*Roflumilast N-oxide* (Standard)**	Drug Metabolite Reference Standards Phosphodiesterase (PDE)	Inflammation/Immunology
Roflumilast N-oxide (Standard) is the analytical standard of Roflumilast N-oxide. This product is intended for research and analytical applications. Roflumilast N-oxide is a PDE type 4 inhibitor.

HY-133724

Vardenafil N-oxide	Drug Metabolite	Metabolic Disease Inflammation/Immunology Endocrinology
Vardenafil N-oxide is a N-Oxide impurity of Vardenafil (HY-B0442) .

HY-141773S

*Benzydamine N-oxide-d6*	Isotope-Labeled Compounds	Others
Benzydamine N-oxide-d₆ is the deuterium labeled Benzydamine N-oxide .

HY-133794S

*Dasatinib N-oxide-d8*	Isotope-Labeled Compounds Drug Metabolite	Cancer
Dasatinib N-oxide-d₈ is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor .

HY-135265

Moclobemide N-Oxide Ro 12-5637	Monoamine Oxidase	Neurological Disease
Moclobemide N-Oxide (Ro 12-5637) is N-oxide metabolite of Moclobemide. Moclobemide N-Oxide retains certain MAO-A (monoamine oxidase) inhibitory activity, but is generally present in low concentrations. Moclobemide N-Oxide can be detected by UV absorption at 240 nm .

HY-W700973S

*Chlorpheniramine N-oxide-d6*	Isotope-Labeled Compounds	Others
Chlorpheniramine N-oxide-d₆ is the deuterium labeled Chlorpheniramine N-oxide.

HY-137989

Voriconazole N-oxide Voriconazole oxynitride	Fungal	Infection
Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB) .

HY-101407R

*Nicotinamide N-oxide* (Standard)**	Reference Standards CXCR Drug Metabolite Endogenous Metabolite	Inflammation/Immunology Endocrinology
Nicotinamide N-oxide (Standard) is the analytical standard of Nicotinamide N-oxide. This product is intended for research and analytical applications. Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

HY-146481S

*Lansoprazole sulfone N-oxide-d4*	Isotope-Labeled Compounds	Others
Lansoprazole sulfone N-oxide-d₄ is the deuterium labeled Lansoprazole sulfone N-oxide .

HY-133590

Heliotrine N-oxide	DNA Alkylator/Crosslinker	Cancer
Heliotrine N-oxide is the corresponding PA (pyrrolizidine alkaloid) N-oxide of Heliotrine (HY-126128). Heliotrine N-oxide leads to the formation of pyrrolic DNA adducts and potential initiation of PA-induced liver tumors in vivo .

HY-116084R

*Trimethylamine N-oxide* (Standard)**	Drug Metabolite NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite Reference Standards	Cardiovascular Disease Inflammation/Immunology
Trimethylamine N-oxide (Standard) is the analytical standard of Trimethylamine N-oxide. This product is intended for research and analytical applications. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-138199S

*Omeprazole sulfone N-oxide-13C,d3*	Isotope-Labeled Compounds	Others
Omeprazole sulfone N-oxide- ¹³C,d₃ is the deuterium and ¹³C labeled Omeprazole sulfone N-Oxide .

HY-100636

Gefitinib N-oxide	EGFR	Cancer
Gefitinib N-oxide is the N-oxide derivative of Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC₅₀ of 2-37 nM in NR6wtEGFR cells .

HY-151241

Sinomenine N-oxide (+)-Sinomenine N-oxide	NO Synthase	Inflammation/Immunology
Sinomenine N-oxide has anti-angiogenic, anti-inflammatory and anti-rheumatic effects. Sinomenine N-oxide is also a NO production inhibitor, with an IC₅₀ value of 23.04 μM .

HY-147085

Loratadine n-oxide	Histamine Receptor	Inflammation/Immunology
Loratadine n-oxide is a metabolite of Loratadine. Loratadine n-oxide shows antihistamine activity .

HY-116832

Retrorsine N-oxide	NO Synthase	Cancer
Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides .

HY-133724R

*Vardenafil N-oxide* (Standard)**	Reference Standards Drug Metabolite	Metabolic Disease Inflammation/Immunology Endocrinology
Vardenafil N-oxide (Standard) is the analytical standard of Vardenafil N-oxide. This product is intended for research and analytical applications. Vardenafil N-oxide is a N-Oxide impurity of Vardenafil (HY-B0442) .

HY-N9512S

*Lycopsamine N-oxide-d3*	Isotope-Labeled Compounds	Others
Lycopsamine N-oxide-d₃ is the deuterium labeled Lycopsamine N-oxide. Lycopsamine N-oxide, an N-oxide of Lycopsamine which is a pyrrolizidine alkaloid, can be found in honey and bee pollen .

HY-137989S

*Voriconazole N-oxide-d3* Voriconazole oxynitride-d₃	Isotope-Labeled Compounds Fungal	Infection
Voriconazole N-oxide-d₃ (Voriconazole oxynitride-d₃) is deuterium labeled Voriconazole N-oxide. Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB) .

HY-N15707

Isocorydine N-oxide (+)-Isocorydine N-oxide	Cholinesterase (ChE)	Neurological Disease
Isocorydine N-oxide ((+)-Isocorydine N-oxide), an alkaloidal, a acetylcholinesterase (AChE) inhibitor. Isocorydine N-oxide can be used for the study of Alzheimer's disease .

HY-B1061R

*Nicotinic acid N-oxide* (Standard)**	Drug Derivative Reference Standards	Cardiovascular Disease
Nicotinic acid N-oxide (Standard) is the analytical standard of Nicotinic acid N-oxide. This product is intended for research and analytical applications. Nicotinic acid N-oxide can be used for research on hyperlipidemia.

HY-N2561

Seneciphylline N-Oxide	Others	Cancer
Seneciphylline N-Oxide is a dehydrogenation product of Senecionine N-oxide. Seneciphylline N-Oxide is a natural compound isolated from root cultures of Senecio erucifolius (Asteraceae) .

HY-N16472

Echiumine N-oxide	Endogenous Metabolite	Others
Echiumine N-oxide, a pyrrolizidine alkaloid related N-oxides (PANOs), is a plant secondary metabolite. Echiumine N-oxide can be isolated from Echium plantagineum. Echiumine N-oxide acts as a defensive role in plants, prevent plants from tissue death .

HY-100644

Trimethoprim N-oxide Trimethoprim 1-N-oxide	Drug Metabolite	Infection
Trimethoprim N-oxide (Trimethoprim 1-N-oxide) belongs to human urinary metabolites. Trimethoprim N-oxide is generated by oxidation of nitrogen atoms in the pyrimidine ring. Trimethoprim N-oxide is formed predominantly by CYP1A2 in human liver microsomes .

HY-135586R

*Raloxifene N-Oxide* (Standard)**	Reference Standards Drug Metabolite	Metabolic Disease
Raloxifene N-Oxide (Standard) is the analytical standard of Raloxifene N-Oxide. This product is intended for research and analytical applications. Raloxifene N-Oxide is a Raloxifene oxidative degradation product .

HY-W740127

Quinidine-d3 N-Oxide	Isotope-Labeled Compounds	Others
Quinidine-d₃ N-Oxide is the deuterium labeled Quinidine N-Oxide.

HY-134137S

*Donepezil N-oxide-d5*	Isotope-Labeled Compounds	Others
Donepezil N-oxide-d₅ is deuterium labeled Donepezil N-oxide.

HY-N6828R

*Monocrotaline N-Oxide* (Standard)**	Reference Standards Others	Metabolic Disease
Monocrotaline N-Oxide (Standard) is the analytical standard of Monocrotaline N-Oxide. This product is intended for research and analytical applications. Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .

HY-N2561AR

*Spartioidine N-oxide* (Standard)**	Reference Standards Others	Others
Spartioidine N-oxide (Standard) is the analytical standard of Spartioidine N-oxide. This product is intended for research and analytical applications. Spartioidine N-oxide is a pyrrolizidine alkaloid and can be isolated from Senecio vulgaris .

HY-W769381

*Lycopsamine N-oxide-d7*	Isotope-Labeled Compounds	Others
Lycopsamine N-oxide-d₇ is deuterium labeled Lycopsamine N-oxide .

HY-144239S

*Venlafaxine N-oxide-d6*	Isotope-Labeled Compounds	Others
Venlafaxine N-oxide-d₆ is the deuterium labeled Venlafaxine N-oxide .

HY-135740S

*Diphenhydramine N-oxide-d6*	Isotope-Labeled Compounds	Others
Diphenhydramine N-?Oxide-d₆ is the deuterium labeled Diphenhydramine N-?Oxide .

HY-W701397

*Nicotinamide N-oxide-d4*	Isotope-Labeled Compounds CXCR Drug Metabolite Endogenous Metabolite Oxidative Phosphorylation	Inflammation/Immunology
Nicotinamide N-oxide-d₄ is the deuterium labeled Nicotinamide N-oxide (HY-101407). Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

HY-148377

Abiraterone sulfate N-oxide	Drug Metabolite	Cancer
Abiraterone sulfate N-oxide is a carboxylic acid. Abiraterone sulfate N-oxide also is a major metabolite of Abiraterone (HY-70013). Abiraterone sulfate N-oxide can be used for the research of prostate cancer .

Cat. No.	Product Name	Type

HY-D2339

H-FluNox	Fluorescent Dyes
H-FluNox is a selective fluorescent probe that senses labile heme using biomimetic N-oxide deoxygenation to trigger fluorescence. H-FluNox is more than 100-fold selective for labile heme over Fe(II), enabling the discrimination of labile heme from labile Fe(II) pools in living cells. H-FluNox is sensitive enough to detect the subcellular labile heme. (λ_ex=490 nm, λ_em=535 nm)

HY-D3377

HMRhoNox-M

LysoRhoNox

Fluorescent Dyes

HMRhoNox-M (LysoRhoNox) is a selective fluorescent probe for labile Fe ²⁺ with an orange fluorescence, and its excitation/emission wavelength is λₑₓ/λₑₘ = 555/575 nm. HMRhoNox-M undergoes N-oxide deoxygenation mediated by Fe ²⁺, converting from a non-fluorescent spirocyclic closed form to a fluorescent quinone open form. HMRhoNox-M is used to detect labile Fe ²⁺ in living cells .

Cat. No.	Product Name	Type

HY-W127785

N,N-Dimethyldodecylamine N-oxide

N,N-Dimethyldodecan-1-amine oxide; Dodecyldimethylamine oxide

Biochemical Assay Reagents

N,N-Dimethyldodecylamine N-oxide is an amine oxide surfactant commonly used as a detergent, emulsifier and wetting agent in various industrial processes, especially in personal care products and household cleaning in the production of agents. N,N-Dimethyldodecylamine N-oxide has unique chemical properties that make it an effective ingredient in many product formulations to help reduce surface tension and enhance cleaning power.

HY-W127842

N,N-Dimethyldecylamine N-oxide

Decyldimethylamine oxide

Biochemical Assay Reagents

N,N-Dimethyldecylamine N-oxide is an organic compound belonging to the family of amine oxides. It is commonly used as a surfactant and cleaning agent in a variety of industrial and household applications, including detergents, personal care products and paints. N,N-Dimethyldecylamine N-oxide has various properties suitable for these applications, including the ability to lower surface tension, increase solubility, and act as a blowing agent. In addition, it can be used as a corrosion inhibitor in metalworking fluids and a flotation agent in mineral processing.

HY-W127785R

N,N-Dimethyldodecylamine N-oxide (Standard)

N,N-Dimethyldodecan-1-amine oxide (Standard); Dodecyldimethylamine oxide (Standard)

Biochemical Assay Reagents

N,N-Dimethyldodecylamine N-oxide (Standard) is the analytical standard of N-ethyl-N-oxido-dodecan-1-amine. This product is intended for research and analytical applications. N,N-Dimethyldodecylamine N-oxide is an amine oxide surfactant commonly used as a detergent, emulsifier and wetting agent in various industrial processes, especially in personal care products and household cleaning in the production of agents. N,N-Dimethyldodecylamine N-oxide has unique chemical properties that make it an effective ingredient in many product formulations to help reduce surface tension and enhance cleaning power.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-116084

Trimethylamine N-oxide Maximum Cited Publications 11 Publications Verification	Cardiovascular Disease Natural Products Microorganisms Other disease Classification of Application Fields Disease markers Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer Source Classification	Drug Metabolite NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite
Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-W012977

3,3-Dimethyl-1-butanol 1 Publications Verification DMB; Neohexanol	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	TGF-beta/Smad NF-κB Endogenous Metabolite
3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-Dimethyl-1-butanol inhibits the signaling pathway of p65 NF-κB and TGF-β1/Smad3. 3,3-Dimethyl-1-butanol has potential applications in cardiovascular disease (CVD) .

HY-114202

delta-Valerobetaine 2 Publications Verification	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
delta-Valerobetaine is a precursor of trimethylamine N-oxide (TMAO).

HY-108915

*Trimethylamine N-oxide* dihydrate** Maximum Cited Publications 11 Publications Verification	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite
Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide dihydrate induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide dihydrate also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-101407

Nicotinamide N-oxide 3 Publications Verification	Alkaloids Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Oxidative Phosphorylation CXCR Drug Metabolite Endogenous Metabolite
Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

HY-B1340

Carbadox 1 Publications Verification	Infection Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Bacterial Antibiotic Endogenous Metabolite
Carbadox is a quinoxaline-di-N-oxide antibiotic compound which is widely fed to nursery-age pigs to control enteric diseases and improve feed efficiency.

HY-N8723

(1′S,2′S)-Nicotine-1'-oxide	Natural Products Nicotiana tabacum L. Plants Solanaceae Source Classification	Others
(1′S,2′S)-Nicotine-1'-oxide is an alkaloid N-oxide from the leaves, stems and roots of Nicotiana tabacum .

HY-N1402

Oxysophoridine Sophoridine N-oxide	Alkaloids other families Classification of Application Fields Pyridine Alkaloids Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects .

HY-N11425

Benzydamine N-Oxide	Natural Products Endogenous metabolite Source Classification	Others
Benzydamine N-Oxide is a metabolite of Benzydamine. Benzydamine N-Oxide can be used to measure flavin-containing monooxygenase activity .

HY-N6827

Usaramine N-oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Leguminosae Plants Crotalaria pallida Ait. Disease Research Fields Inflammation/Immunology Source Classification	Others
Usaramine N-oxide, a alkaloid isolated from Crotalaria pallida, possesses anti-inflammatory activities .

HY-105529

Indicine N-oxide (+)-Indicine N-oxide; NSC 132319	Alkaloids Pyrrole Alkaloids Classification of Application Fields Tournefortia argentea Linnaeus f. Plants Boraginaceae Disease Research Fields Source Classification Cancer	Microtubule/Tubulin
Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research .

HY-101407R

*Nicotinamide N-oxide* (Standard)**	Alkaloids Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Reference Standards CXCR Drug Metabolite Endogenous Metabolite
Nicotinamide N-oxide (Standard) is the analytical standard of Nicotinamide N-oxide. This product is intended for research and analytical applications. Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

HY-116084R

*Trimethylamine N-oxide* (Standard)**	Structural Classification Natural Products Microorganisms Other disease Disease markers Endogenous metabolite Cancer Source Classification	Drug Metabolite NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite Reference Standards
Trimethylamine N-oxide (Standard) is the analytical standard of Trimethylamine N-oxide. This product is intended for research and analytical applications. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-136486

Lasiocarpine N-oxide	Pyrrolizidine Alkaloids Alkaloids Heliotropium rotundifolium Classification of Application Fields Other Alkaloids Plants Boraginaceae Disease Research Fields Source Classification Cancer	Others
Lasiocarpine N-oxide is a natural compound with antitumor activity .

HY-N6828

Monocrotaline N-Oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Leguminosae Metabolic Disease Plants Crotalaria pallida Ait. Disease Research Fields Source Classification	Others
Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .

HY-116832

Retrorsine N-oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Plants Compositae Baptisia australis (L.) R. Br. Disease Research Fields Source Classification Cancer	NO Synthase
Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides .

HY-N15707

Isocorydine N-oxide (+)-Isocorydine N-oxide	Alkaloids Glaucium corniculatum (L.) Curtis Quinoline Alkaloids Plants Papaveraceae Source Classification	Cholinesterase (ChE)
Isocorydine N-oxide ((+)-Isocorydine N-oxide), an alkaloidal, a acetylcholinesterase (AChE) inhibitor. Isocorydine N-oxide can be used for the study of Alzheimer's disease .

HY-N2561

Seneciphylline N-Oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Erinacea anthyllis Link Plants Compositae Disease Research Fields Cancer Source Classification	Others
Seneciphylline N-Oxide is a dehydrogenation product of Senecionine N-oxide. Seneciphylline N-Oxide is a natural compound isolated from root cultures of Senecio erucifolius (Asteraceae) .

HY-N16472

Echiumine N-oxide	Structural Classification Alkaloids Echium plantagineum L. Other Alkaloids Plants Boraginaceae Source Classification	Endogenous Metabolite
Echiumine N-oxide, a pyrrolizidine alkaloid related N-oxides (PANOs), is a plant secondary metabolite. Echiumine N-oxide can be isolated from Echium plantagineum. Echiumine N-oxide acts as a defensive role in plants, prevent plants from tissue death .

HY-N6828R

*Monocrotaline N-Oxide* (Standard)**	Alkaloids Structural Classification Pyrrole Alkaloids Leguminosae Crotalaria pallida Ait. Plants Source Classification	Reference Standards Others
Monocrotaline N-Oxide (Standard) is the analytical standard of Monocrotaline N-Oxide. This product is intended for research and analytical applications. Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .

HY-N2561AR

*Spartioidine N-oxide* (Standard)**	Pterogyne nitens Tul. Alkaloids Other Alkaloids Plants Compositae Source Classification	Reference Standards Others
Spartioidine N-oxide (Standard) is the analytical standard of Spartioidine N-oxide. This product is intended for research and analytical applications. Spartioidine N-oxide is a pyrrolizidine alkaloid and can be isolated from Senecio vulgaris .

HY-N6827R

*Usaramine N-oxide* (Standard)**	Alkaloids Pyrrole Alkaloids Leguminosae Crotalaria pallida Ait. Plants Source Classification	Reference Standards Others
Usaramine N-oxide (Standard) is the analytical standard of Usaramine N-oxide. This product is intended for research and analytical applications. Usaramine N-oxide, a alkaloid isolated from Crotalaria pallida, possesses anti-inflammatory activities .

HY-N16468

Riddelliine N-oxide	Pterogyne nitens Tul. Structural Classification Alkaloids Other Alkaloids Plants Compositae Source Classification	Drug Derivative
Riddelliine N-oxide is a hepatotoxic agent. Riddelliine N-oxide is promising for research of liver-related diseases .

HY-N9512

Lycopsamine N-oxide	Alkaloids other families Pyrrole Alkaloids Classification of Application Fields Other Diseases Plants Disease Research Fields Source Classification	Others
Lycopsamine N-oxide, an N-oxide of Lycopsamine which is a pyrrolizidine alkaloid, can be found in honey and bee pollen .

HY-W707957

Intermedine N-oxide	Pyrrolizidine Alkaloids Alkaloids Animals Source Classification	Drug Intermediate
Intermedine N-oxide is a pyrrolizidine alkaloid indicine that can be found in Crotalaria spectabilis. Intermedine N-oxide shows anticancer activity .

HY-N9511

Jacobine N-oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Other Diseases Plants Compositae Baptisia australis (L.) R. Br. Disease Research Fields Source Classification	Others
Jacobine N-oxide, an N-oxide of Jacobine which is a pyrrolizidine alkaloid, can be found in Senecio hybrids that has thrips resistance .

HY-108915R

*Trimethylamine N-oxide* dihydrate (Standard)**	Structural Classification Natural Products Endogenous metabolite Source Classification	NOD-like Receptor (NLR) Reactive Oxygen Species (ROS) TGF-beta/Smad Endogenous Metabolite Reference Standards
Trimethylamine N-oxide (dihydrate) (Standard) is the analytical standard of Trimethylamine N-oxide (dihydrate). This product is intended for research and analytical applications. Trimethylamine N-oxide dihydrate is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide dihydrate induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide dihydrate also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-N14959

Deacetylravidomycin N-oxide	Natural Products Microorganisms Source Classification	Antibiotic Bacterial
Deacetylravidomycin N-oxide is an antibiotic that can be produced by Streptomyces ravidus S50905. Deacetylravidomycin N-oxide is active against Gram-positive bacteria but inactive against Gram-negative bacteria. Deacetylravidomycin N-oxide has antitumor activity against P388 leukemia and methamphetamine A fibrosarcoma .

HY-131574

Heliosupine N-oxide	Alkaloids Pyrrole Alkaloids Cynoglossumofficinale Linn. Plants Boraginaceae Source Classification	mAChR
Heliosupine N-oxide, Heliosupin metabolite, inhibits muscarinic acetylcholine receptor (mAChR) with the IC₅₀ of 350 μM. Heliosupine N-oxide is a pyrrolizidine alkaloid (PA) .

HY-N6637

Senecionine N-oxide	Pterogyne nitens Tul. Alkaloids Pyrrole Alkaloids Classification of Application Fields Plants Compositae Disease Research Fields Cancer Source Classification	Others
Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity .

HY-N7263

Galanthamine N-Oxide	Alkaloids other families Plants Source Classification	Cholinesterase (ChE)
Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC₅₀ of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes .

HY-131587

Integerrimine N-oxide	Sabina vulgaris Ant. Alkaloids Cupressaceae Pyrrole Alkaloids Classification of Application Fields Other Diseases Plants Disease Research Fields Source Classification	Others
Integerrimine N-oxide, the main pyrrolizidine alkaloid found in the butanolic residue (BR) of Senecio brasiliensis. Prenatal exposure to integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delays in physical and behavioral development of the offspring .

HY-N7774

Echinatine N-oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Heliotropium indicum L. Other Diseases Plants Disease Research Fields Boraginaceae Source Classification	Others
Echinatine N-oxide is a pyrrolizidine alkaloid found in R. graeca .

HY-N3105

Paxiphylline D Longistylumphylline A N-oxide	Daphniphyllum paxianum K. Rosenth. Alkaloids Pyrrole Alkaloids Plants Source Classification	Others
Paxiphylline D (Longistylumphylline A N-oxide) is a product that can be isolated from .

HY-118288

Aurachin B	Alkaloids Microorganisms Quinoline Alkaloids Source Classification	Parasite
Aurachin B is an alkaloid with a 3-hydroxyquinoline N-oxide core .

HY-131578

Rinderine N-oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Cynoglossumofficinale Linn. Metabolic Disease Plants Boraginaceae Disease Research Fields Source Classification	Others
Rinderine N-oxide is a pyrrolizidine alkaloid that can be found in R. graeca .

HY-N2561A

Spartioidine N-oxide	Pterogyne nitens Tul. Alkaloids Other Alkaloids Plants Compositae Source Classification	Others
Spartioidine N-oxide is a pyrrolizidine alkaloid and can be isolated from Senecio vulgaris .

HY-N3416

Koumine N-oxide	Alkaloids Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Indole Alkaloids Source Classification	Others
Koumine N-oxide is an alkaloid compound isolated from the herb Gelsemium elegans .

HY-N9501

Retronecine N-oxide	Structural Classification Alkaloids Pyrrole Alkaloids Plants Boraginaceae Arnebia euchroma (Royle) Johnst. Source Classification	Others
Retronecine N-oxide is a Alkaloids product that can be isolated from the roots of Arnebia euchroma .

HY-N8965

Scandine N-oxide	Apocynaceae Alkaloids Piperidine Alkaloids Melodinus fusiformis Champ. ex Benth. Plants Source Classification	Others
Scandine N-oxide is a Alkaloids product that can be isolated from the dried herbs of Melodinus fusiformis. .

HY-N11812

Erucifoline N-oxide	Alkaloids Erinacea anthyllis Link Pyridine Alkaloids Plants Compositae Source Classification	Others
Erucifoline N-oxide, a natural compound that can be isolated from Senecio persoonia, possesses hepatotoxic activity .

HY-N8681

9-Angeloylretronecine N-oxide	Alkaloids Pyrrole Alkaloids Plants Boraginaceae Arnebia euchroma (Royle) Johnst. Source Classification	Others
9-Angeloylretronecine N-oxide is a Alkaloids product that can be isolated from the roots of Arnebia euchroma .

HY-N9513

Echimidine N-oxide	Alkaloids Pyrrole Alkaloids Plants Boraginaceae Echium vulgare L. Source Classification	Cholinesterase (ChE)
Echimidine N-oxide, a pyrrolizidine alkaloid, has acetylcholinesterase (AChE) inhibitory activity (IC_{50=0.347 mM) .}

HY-N8620

9-Methoxycanthin-6-one-N-oxide	Alkaloids Simaroubaceae Ailanthus altissima (Mill.) Swingle Plants Indole Alkaloids Source Classification	Others
9-Methoxycanthin-6-one-N-oxide is a Alkaloids product that can be isolated from the barks of Ailanthus altissima .

HY-N15616

Parsonsine	Alkaloids Animals Other Alkaloids Source Classification	Biochemical Assay Reagents
Parsonsine is ananalog of pyrrolizidine alkaloid that can be isolated in the N-oxide forms from adult bodies of the Apocynaceae-feeding danaine butterfly, Idea leuconoe .

HY-129130

Canthin-6-one N-oxide Canthin-6-one 3-oxide	Alkaloids Simaroubaceae Other Alkaloids Eurycoma harmandiana Pierre Plants Source Classification	Parasite
Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity .

HY-121390

Lasiocarpine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Plants Disease Research Fields Boraginaceae Heliotropium europaeum L. Cancer Source Classification	Endogenous Metabolite
Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide .

HY-N16484

Trichodesmine N-oxide	Structural Classification Alkaloids Other Alkaloids Plants Trichodesma incanum (Bunge) A.DC. Boraginaceae Source Classification	Others
Trichodesmine N-oxide is the oxidized form of a pyrrolizidine alkaloid (PA) that can be isolated from the sunn hemp (Crotalaria juncea) teas. PAs are secondary metabolites in plants, which may exhibit toxicity and carcinogenicity .

HY-B1340R

Carbadox (Standard)	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Bacterial Antibiotic Endogenous Metabolite
Carbadox (Standard) is the analytical standard of Carbadox. This product is intended for research and analytical applications. Carbadox is a quinoxaline-di-N-oxide antibiotic compound which is widely fed to nursery-age pigs to control enteric diseases and improve feed efficiency.

HY-130059

Guanine-7-oxide Guanine 7-N-oxide	Structural Classification Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Fungal HSV
Guanine-7-oxide (Guanine 7-N-oxide) is an antitumor antibiotic with anti-tumor, anti-Candida albicans activity, and can inhibit viral replication effect of herpes virus, infectious blood virus (IHNV), infectious pancreatic necrosis virus (IPNV) and so on. Guanine-7-oxide has good activity against mouse L1210 leukemia cells .

Cat. No.	Product Name	Chemical Structure

HY-116084S

Trimethylamine N-oxide-d9

1 Publications Verification

Trimethylamine N-oxide-d₉ is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-114202S

delta-Valerobetaine-d9 chloride 2 Publications Verification
delta-Valerobetaine-d₉ chloride is the deuterium labeled delta-Valerobetaine (HY-114202) . delta-Valerobetaine is a precursor of trimethylamine N-oxide (TMAO) .

HY-N6637S

*Senecionine N-oxide-d3*
Senecionine N-oxide-d₃ is the deuterium labeled Senecionine N-oxide. Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity .

HY-116084S1

Trimethylamine-N-oxide-13C3

Trimethylamine-N-oxide- ¹³C₃ is the ¹³C-labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-W016099S

3-Methyl-2-quinoxalinecarboxylic acid-d4
3-Methyl-2-quinoxalinecarboxylic acid-d₄ is the deuterium labeled 3-Methyl-2-quinoxalinecarboxylic acid. 3-Methyl-2-quinoxalinecarboxylic acid (MQCA), an important N-oxide reductive metabolite of Quinocetone or Olaquindox, potently inhibits the growth of Chang liver cells through S phase arrest of the cell cycle .

HY-141773S

*Benzydamine N-oxide-d6*
Benzydamine N-oxide-d₆ is the deuterium labeled Benzydamine N-oxide .

HY-133794S

*Dasatinib N-oxide-d8*
Dasatinib N-oxide-d₈ is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor .

HY-W700973S

*Chlorpheniramine N-oxide-d6*
Chlorpheniramine N-oxide-d₆ is the deuterium labeled Chlorpheniramine N-oxide.

HY-146481S

*Lansoprazole sulfone N-oxide-d4*
Lansoprazole sulfone N-oxide-d₄ is the deuterium labeled Lansoprazole sulfone N-oxide .

HY-138199S

*Omeprazole sulfone N-oxide-13C,d3*
Omeprazole sulfone N-oxide- ¹³C,d₃ is the deuterium and ¹³C labeled Omeprazole sulfone N-Oxide .

HY-W700867

*Alpha-Carboline N-Oxide-15N2*
Alpha-Carboline N-Oxide- ¹⁵N₂ is the ¹⁵N labeled 9H-Pyrido[2,3-b]indole 1-oxide (HY-W700873).

HY-12987S1

Pimozide-d5 N-Oxide
Pimozide-d₅ N-Oxide is the deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with K_is of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5 .

HY-B0185S

Lidocaine-d10 N-Oxide

N-Oxide Lidocaine-d₁₀ is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence . Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia .

HY-N9512S

*Lycopsamine N-oxide-d3*
Lycopsamine N-oxide-d₃ is the deuterium labeled Lycopsamine N-oxide. Lycopsamine N-oxide, an N-oxide of Lycopsamine which is a pyrrolizidine alkaloid, can be found in honey and bee pollen .

HY-137989S

*Voriconazole N-oxide-d3*
Voriconazole N-oxide-d₃ (Voriconazole oxynitride-d₃) is deuterium labeled Voriconazole N-oxide. Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB) .

HY-W740127

Quinidine-d3 N-Oxide
Quinidine-d₃ N-Oxide is the deuterium labeled Quinidine N-Oxide.

HY-134137S

*Donepezil N-oxide-d5*
Donepezil N-oxide-d₅ is deuterium labeled Donepezil N-oxide.

HY-W769381

*Lycopsamine N-oxide-d7*
Lycopsamine N-oxide-d₇ is deuterium labeled Lycopsamine N-oxide .

HY-144239S

*Venlafaxine N-oxide-d6*
Venlafaxine N-oxide-d₆ is the deuterium labeled Venlafaxine N-oxide .

HY-135740S

*Diphenhydramine N-oxide-d6*
Diphenhydramine N-?Oxide-d₆ is the deuterium labeled Diphenhydramine N-?Oxide .

HY-W701397

*Nicotinamide N-oxide-d4*
Nicotinamide N-oxide-d₄ is the deuterium labeled Nicotinamide N-oxide (HY-101407). Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.

HY-W709612

*Regorafenib N-oxide* and N-desmethyl (M5)-d3-1**
Regorafenib N-oxide and N-desmethyl (M5)-d₃-1 (N-Desmethyl regorafenib N-oxide-d₃-1) is the deuterium labeled Regorafenib N-oxide and N-desmethyl (M5) (HY-108226). Regorafenib N-oxide and N-desmethyl (M5) (N-Desmethyl regorafenib N-oxide) is an active metabolite of Sorafenib (HY-10201) and can be metabolized by CYP3A4 .

HY-G0011S

*Netupitant N-oxide-d6*
Netupitant N-oxide-d₆ is the deuterium labeled Netupitant N-oxide, which is a metabolite of Netupitant.

HY-138199S1

*Omeprazole sulfone N-oxide-d3*
Omeprazole sulfone N-oxide-d₃ is the deuterium labeled Omeprazole sulfone N-Oxide .

HY-W753452

*N,N-Dimethyltryptamine N-oxide-d6*
N,N-Dimethyltryptamine N-oxide-d₆ is the deuterium labeled N,N-Dimethyltryptamine N-oxide (HY-W576312). N,N-Dimethyltryptamine N-oxide is a metabolite of N,N-Dimethyltryptamine .

HY-W739718

(R,S)-Cotinine-d3 N-Oxide
(R,S)-Cotinine-d₃ N-Oxide is the deuterium labeled (R,S)-Cotinine N-Oxide.

HY-142440S

*Apatinib 25-N-oxide-d8 dihydrochloride*
Apatinib 25-N-oxide-d₈ (dihydrochloride) is the deuterium labeled Apatinib 25-N-oxide dihydrochloride .

HY-W748582

Clozapine N-oxide-d8

Clozapine N-oxide-d₈ is the deuterium labeled Clozapine N-oxide (HY-17366). Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC₅₀=11 nM) agonist .

HY-W722562

Trimethylamine oxide-15N

Trimethylamine oxide- ¹⁵N is the deuterium labeled Trimethylamine N-oxide (HY-116084). Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway .

HY-108226S

*Regorafenib N-oxide* and N-desmethyl (M5)-d3**
Regorafenib N-oxide and N-desmethyl (M5)-d₃ is deuterium labeled Regorafenib N-oxide and N-desmethyl (M5).

HY-108226S1

*Regorafenib N-oxide* and N-desmethyl (M5)-13C6**
Regorafenib N-oxide and N-desmethyl (M5)- ¹³C₆ is the ¹³C-labeled Regorafenib N-oxide and N-desmethyl (M5) .

HY-136428S

Desoxycarbadox-d3 1 Publications Verification
Desoxycarbadox-d₃ is the deuterium labeled Desoxycarbadox. Desoxycarbadox is a metabolite of Carbadox (HY-B1340). Carbadox is a quinoxaline-di-N-oxide antibiotic compound.

HY-14538S2

Haloperidol-d4 N-Oxide
Haloperidol-d₄ N-Oxide is the deuterium labeled Haloperidol. Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic .

HY-B1340S

Carbadox-d3
Carbadox-d₃ is the deuterium labeled Carbadox. Carbadox is a quinoxaline-di-N-oxide antibiotic compound which is widely fed to nursery-age pigs to control enteric diseases and improve feed efficiency.

HY-14545S1

Amisulpride-d5 N-Oxide
Amisulpride-d₅ N-Oxide is the deuterium labeled Amisulpride. Amisulpride is a dopamine D2/D3 receptor antagonist with K_is of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively .

HY-W741847

*Tapentadol N-Oxide-d5*
Tapentadol N-Oxide-d₅ is the deuterium labeled (2R,3R)-3-(3-Hydroxyphenyl)-N,N,2-trimethylpentan-1-amine oxide (HY-W703015).

HY-15455S1

Roflumilast-d4 N-Oxide
Roflumilast-d₄ N-Oxide is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC₅₀s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells .

HY-W710279

N-ethyl-N-oxido-dodecan-1-amine-d6

N-ethyl-N-oxido-dodecan-1-amine-d₆ is the deuterium labeled N-ethyl-N-oxido-dodecan-1-amine (HY-W127785). N-ethyl-N-oxido-dodecan-1-amine is an amine oxide surfactant commonly used as a detergent, emulsifier and wetting agent in various industrial processes, especially in personal care products and household cleaning in the production of agents. N,N-Dimethyldodecylamine N-oxide has unique chemical properties that make it an effective ingredient in many product formulations to help reduce surface tension and enhance cleaning power.

HY-W698938

*Pyridine N-oxide-d5*
Pyridine N-oxide-d₅ is the deuterium labeled Pyridine N-oxide.

HY-W703386

Bupivacaine-d9 N-Oxide
Bupivacaine-d₉ N-Oxide is the deuterium labeled Bupivacaine N-Oxide.

HY-133786S

*Clemastine N-oxide-d5*
Clemastine N-oxide-d₅ is the deuterium labeled Clemastine N-oxide.

HY-W710291

*Rivastigmine N-oxide-d6*
Rivastigmine N-oxide-d₆ is the deuterium labeled Rivastigmine N-oxide.

HY-119393S

*Olanzapine N-Oxide-d3*
Olanzapine N-Oxide-d3 is a deuterated labeled Olanzapine N-Oxide .

HY-132447S

Nefopam-d3 N-Oxide
Nefopam-d₃ N-Oxide is the deuterium labeled Nefopam N-Oxide .

HY-141783S

*Clomipramine N-Oxide-d6*
Clomipramine N-Oxide-d₆ is the deuterium labeled Clomipramine N-Oxide .

HY-133797S

*Cyclobenzaprine N-oxide-d3*
Cyclobenzaprine N-oxide-d₃ is the deuterium labeled Cyclobenzaprine N-oxide .

HY-133792S

*Olopatadine N-oxide-d6*
Olopatadine-d₃ N-Oxide is the deuterium labeled Olopatadine N-Oxide .

HY-W087967S

*4-Nitropyridine N-oxide-d4*
4-Nitropyridine N-oxide-d₄ is the deuterium labeled 4-Nitropyridine N-oxide .

HY-132343S

*Zolmitriptan N-Oxide-d6*
Zolmitriptan N-Oxide-d₆ is a deuterium labeled Zolmitriptan N-Oxide. Zolmitriptan N-Oxide is the major metabolite of Zolmitriptan. Zolmitriptan is a 5-HT1B/1D receptor partial agonist .

HY-W742574

*Venlafaxine N-Oxide-d6-1*
Venlafaxine N-Oxide-d₆-1 is the deuterium labeled 2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)-N,N-dimethylethan-1-amine oxide (HY-W704254).

Cat. No.	Product Name		Classification

HY-158815

SM-102 N-Oxide Lipid H N-Oxide; LNP-102 N-Oxide		Cationic Lipids
SM-102 N-oxide (Lipid H N-Oxide) is an impurity of SM-102 (HY-134541).

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