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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
240 Results for "
N-oxidation
" in MedChemExpress (MCE) Product Catalog:
Products (240)
240 Results for "N-oxidation" in MCE Product Catalog:
166
166 Publications Verification
Cat. No.: HY-17366
CAS No.: 34233-69-7
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Research Areas:
Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist .
166
166 Publications Verification
Cat. No.: HY-17366A
CAS No.: 2250025-93-3
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Research Areas:
Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride cannot cross the blood-brain barrier . Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist .
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12 Cited Publications
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2 Cited Publications
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1 Cited Publications
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1 Cited Publications
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Roflumilast N-oxide is a PDE type 4 inhibitor.
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1 Cited Publications
1
Category:
Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields Inflammation/Immunology
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Synonyms: N-Methylmorpholine N-Oxide; MMNO; 4-Methylmorpholine 4-oxide
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Research Areas:
4-Methylmorpholine N-oxide (N-Methylmorpholine N-Oxide; MMNO; 4-Methylmorpholine 4-oxide) is an amine oxide ligand and ozonation reagent. 4-Methylmorpholine N-oxide forms coordination complexes with lanthanum (III) nitrate and yttrium (III) nitrate via its nitroso oxygen atom. The metal-ligand bonds are dominated by electrostatic interactions with a small covalent component. 4-Methylmorpholine N-oxide is applicable in ozonation reactions for the synthesis of methyl 9-oxononanoate .
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Imipramine N-oxide is the metabolite of Imipramine. Imipramine N-oxide exhibits low toxicity in rat and mouse experiments. Imipramine N-oxide can be used for the research of endogenous depressions .
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Lignocaine N-oxide (Lidocaine N-oxide) is a hypoxia-activated prodrug of lidocaine (HY-B0185). Lignocaine N-oxide exerts exactly the same sodium current-blocking effect as lidocaine only when it is converted to lidocaine under ischemic conditions. Lignocaine N-oxide possesses antiarrhythmic activity against ischemia-induced ventricular fibrillation. Lignocaine N-oxide can be used in studies related to ischemia-induced ventricular fibrillation .
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Olanzapine N-oxide is a compound under investigation for the metabolism of antipsychotic compounds. Olanzapine N-oxidation and N-demethylation are catalyzed by different enzymes, and its plasma concentration and clearance are not affected by a single factor, such as a specific genotype or smoking behavior.
Cat. No.: HY-W145090
CAS No.: 1005-31-8
Synonyms: p-Dimethylaminopyridine N-oxide
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Research Areas:
4-Dimethylaminopyridine N-oxide (p-Dimethylaminopyridine N-oxide) is an Efficient Oxidizing Agent for Alkyl Halides .
Cat. No.: HY-17366R
CAS No.: 34233-69-7
Research Areas:
Clozapine N-oxide (Standard) is the analytical standard of Clozapine N-oxide. This product is intended for research and analytical applications. Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide cannot cross the blood-brain barrier[1][2][3][4]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[5][6].
Cat. No.: HY-137989A
Purity: 99.52%
Synonyms: Voriconazole oxynitride hydrochloride
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Voriconazole N-oxide (Voriconazole oxynitride) (hydrochloride) is the main metabolite of Voriconazole (HY-76200) , a widely used triazole antibiotic (fungal). Voriconazole N-oxide (hydrochloride) provides information on the patient's drug metabolism capacity .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
