2903-45-9
Chemical Structure
Lignocaine N-oxide
Synonym(s): Lidocaine N-oxide
- No. CAS: 2903-45-9
- Formula:C14H22N2O2
- Molecular Weight:250.34
IUPAC Name: 2-((2,6-dimethylphenyl)amino)-N,N-diethyl-2-oxoethan-1-amine oxide
InChIKey: YDVXPJXUHRROBA-UHFFFAOYSA-N
SMILES: O=C(C[N+](CC)(CC)[O-])NC1=C(C)C=CC=C1C
Biological Activity: Lignocaine N-oxide (Lidocaine N-oxide) is a hypoxia-activated prodrug of lidocaine (HY-B0185). Lignocaine N-oxide exerts exactly the same sodium current-blocking effect as lidocaine only when it is converted to lidocaine under ischemic conditions. Lignocaine N-oxide possesses antiarrhythmic activity against ischemia-induced ventricular fibrillation. Lignocaine N-oxide can be used in studies related to ischemia-induced ventricular fibrillation[1].
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Lignocaine N-oxide | 99.92% | Lignocaine N-oxide (Lidocaine N-oxide) is a hypoxia-activated prodrug of lidocaine (HY-B0185). Lignocaine N-oxide exerts exactly the same sodium current-blocking effect as lidocaine only when it is converted to lidocaine under ischemic conditions. Lignocaine N-oxide possesses antiarrhythmic activity against ischemia-induced ventricular fibrillation. Lignocaine N-oxide can be used in studies related to ischemia-induced ventricular fibrillation. | ||||||||||||||||||||
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N-Oxide Lidocaine-d10 | N-Oxide Lidocaine-d10 is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia. | |||||||||||||||||||||
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