Olanzapine N-oxide
Based on 1 Customer Validation
Olanzapine N-oxide is a phase I metabolite of Olanzapine (HY-14541). Olanzapine N-oxide serves as a substrate for reduction reactions and converts to Olanzapine in whole blood in vitro. Olanzapine is an antipsychotic compound widely used in research on schizophrenia and other psychotic disorders.
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- Reinheit : 98.72%
- CAS. Nr.: 174794-02-6
- Formel: C17H20N4OS
- Molecular Weight:328.43
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Olanzapine N-oxide (0.15-30 ng/mL) undergoes in vitro reduction in blank whole blood at 25 °C to form Olanzapine (HY-14541) and N-desmethylolanzapine (HY-W009247); its limit of quantitation is 0.15 ng/mL in both blank whole blood and urine; moreover, compared with its stability in blank whole blood at 25 °C, it shows higher stability at 4 °C, -30 °C, in blank urine, and in extracted samples[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS. Nr. 174794-02-6
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Appearance Solid
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Molecular Weight 328.43
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Formel C17H20N4OS
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Color Light brown to yellow
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SMILES
CC(S1)=CC2=C1NC3=CC=CC=C3N=C2N4CC[N+](C)([O-])CC4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 125 mg/mL (380.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (292 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Okubo M, et al. Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3. Human psychopharmacology. 2016 Mar;31(2):83-92. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0448 mL | 15.2239 mL | 30.4479 mL | 76.1197 mL |
| 5 mM | 0.6090 mL | 3.0448 mL | 6.0896 mL | 15.2239 mL | |
| 10 mM | 0.3045 mL | 1.5224 mL | 3.0448 mL | 7.6120 mL | |
| 15 mM | 0.2030 mL | 1.0149 mL | 2.0299 mL | 5.0746 mL | |
| 20 mM | 0.1522 mL | 0.7612 mL | 1.5224 mL | 3.8060 mL | |
| 25 mM | 0.1218 mL | 0.6090 mL | 1.2179 mL | 3.0448 mL | |
| 30 mM | 0.1015 mL | 0.5075 mL | 1.0149 mL | 2.5373 mL | |
| 40 mM | 0.0761 mL | 0.3806 mL | 0.7612 mL | 1.9030 mL | |
| 50 mM | 0.0609 mL | 0.3045 mL | 0.6090 mL | 1.5224 mL | |
| 60 mM | 0.0507 mL | 0.2537 mL | 0.5075 mL | 1.2687 mL | |
| 80 mM | 0.0381 mL | 0.1903 mL | 0.3806 mL | 0.9515 mL | |
| 100 mM | 0.0304 mL | 0.1522 mL | 0.3045 mL | 0.7612 mL |
Olanzapine N-oxide Related Classifications
HY-119393 Related Classifications
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