15 Results for "

P-SCN-Bn-NOTA

" in MedChemExpress (MCE) Product Catalog:
Products (15)

15 Results for "P-SCN-Bn-NOTA" in MCE Product Catalog:

Cat. No.: HY-178271
CAS No.: 147597-66-8
Target:  

Drug Intermediate

Research Areas:  

Cancer

P-SCN-Bn-NOTA is a metal chelator and molecular imaging probe precursor that allows radiolabeling with Ga-68. P-SCN-Bn-NOTA can be conjugated to CD70-specific molecules B3, B6, ABDB3 and ABDB6 to form NOTA-labeled derivatives. P-SCN-Bn-NOTA is applicable for preclinical PET/CT imaging of CD70-expressing tumors in NCG mouse PDX models. P-SCN-Bn-NOTA can be used in studies related to CD70-positive tumors .
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Cat. No.: HY-W782083
CAS No.: 1583289-85-3
p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator. p-SCN-Bn-NOTA trihydrochloride can be covalently coupled to molecules such as peptides through the thiocyanate group to form hexacoordinate copper (such as 64Cu) complexes. p-SCN-Bn-NOTA trihydrochloride specifically binds to GRPR or EGFR highly expressed on the surface of tumor cells, mediating tumor enrichment of radioactive probes. p-SCN-Bn-NOTA trihydrochloride can be used to study malignant tumors expressing GRPR or EGFR, such as prostate cancer and colorectal cancer .
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Cat. No.: HY-P10292
NOTA-Pep-1L specifically targets the IL13RA2 receptor for tumor imaging . NOTA-Pep-1L can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
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Cat. No.: HY-178221A
Research Areas:  

Cancer

(S)-P-SCN-BN-NOTA TFA can be conjugated to PDGFRβ affibodies for subsequent radiolabeling. (S)-P-SCN-BN-NOTA TFA is used in pancreatic cancer research .
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Cat. No.: HY-P11347
Target:  

PD-1/PD-L1

Research Areas:  

Cancer

NOTA-AUNP-12 is a PD-L1 antagonist (IC50=2.24×10 −7 M). NOTA-AUNP-12 is promising for research of cancers (e.g., lung/esophageal cancers) .
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Cat. No.: HY-178221
CAS No.: 1206475-68-4
Target:  

Drug Intermediate

Research Areas:  

Cancer

(S)-P-SCN-BN-NOTA is a bifunctional chelating agent that can covalently link the radioactive nuclide ⁶⁴Cu with the ZPDGFRβ affibody, thereby constructing a molecular probe [⁶⁴Cu]Cu-NOTA-ZPDGFRβ for positron emission tomography .
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Cat. No.: HY-175323
Target:  

Integrin PD-1/PD-L1

Research Areas:  

Cancer

NOTA-IMB-RGD is a dual molecular probe targeting integrin αvβ3 and programmed death ligand-1 (PD-L1). NOTA-IMB-RGD blocks the PD-1/PD-L1 signaling pathway and integrin αvβ3-overexpressing tumor vasculature. NOTA-IMB-RGD is promising for research of solid tumors co-expressing PD-L1 and αvβ3 (e.g., glioma, breast cancer) .
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Cat. No.: HY-P10978
Target:  

PD-1/PD-L1

Research Areas:  

Cancer

NK224 is a peptide-based radiotracer targeting human PD-L1, with dual-radionuclide ( 68Ga and 18F) labeling compatibility enabled by the NOTA chelator. NK224 exhibits high binding affinity to PD-L1, with an IC50 value of 2.45 nM. NK224 visualizes intrapatient tumor heterogeneity and dynamically monitors PD-L1 target occupancy during immunotherapy. NK224 can be used for the study of non-small cell lung cancer (NSCLC) .
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Cat. No.: HY-P10220
CAS No.: 2914099-35-5
Research Areas:  

Cancer

NOTA-COG1410 forms triggering receptor expressed on myeloid cells 2 (TREM2) targeting ligand. NOTA-COG1410 is capable of being labelled with 68Gallium ( 68Ga) for discovery and diagnosis of digestive system tumors through positron emission tomography/computed tomography (PET/CT). NOTA-COG1410 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .
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Cat. No.: HY-P11844
Research Areas:  

Cancer

NOTA-FZCD-3 is a NOTA (HY-134418)-labeled FZCD-3 polypeptide precursor that targets cathepsin D (CTSD) with a KD of 0.65 μM. NOTA-FZCD-3 binds specifically to the active site of CTSD, exhibits rapid in vivo clearance properties, and remains stable in blood for more than 2 h. NOTA-FZCD-3 can be used in studies monitoring CTSD-positive tumors .
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Cat. No.: HY-P11859
Research Areas:  

Cancer

NP1 is a NOTA-chelated linear precursor based on the ROR1-targeting peptide. After labeling with [ 18F]AlF, NP1 yields [ 18F]AlF-NP1, a PET imaging probe with excellent ROR1 specificity (KD = 141.7 nM), rapid tumor uptake and high target-to-background ratio, which is suitable for non-invasive visualization of various ROR1-overexpressing tumors .
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Cat. No.: HY-P11945
Target:  

GLP Receptor

Research Areas:  

Metabolic Disease Cancer

NOTA-MAL-Cys39-Exendin-4 is an imaging agent and radiotracer precursor targeting GLP-1R. NOTA-MAL-Cys39-Exendin-4 binds specifically to GLP-1R and is rapidly cleared by the liver and spleen during the blood pool phase. NOTA-MAL-Cys39-Exendin-4 can be efficiently radiolabeled with gallium-68 to form a stable radiotracer with high radiochemical purity. NOTA-MAL-Cys39-Exendin-4 is applicable to research related to insulinomas .
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Cat. No.: HY-P11852
Target:  

FGFR

Research Areas:  

Cancer

NOTA-cRY9M is a reagent targeting FGFR1 with a Kd value of 58 nM, and exhibits subtype selectivity for FGFR2-4. When radiolabeled as [ 68Ga]Ga-NOTA-cRY9M, it functions as a stabilizer, imaging contrast enhancer, and tumor-targeting agent, and accumulates in FGFR1-positive non-small cell lung cancer xenograft models. NOTA-cRY9M can be used in studies related to non-small cell lung cancer .
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Cat. No.: HY-P0036D
CAS No.: 1427427-01-7
NOTA‑Octreotide is a selective SSTR2‑targeting PET tracer. NOTA‑Octreotide binds specifically to SSTR2 and accumulates in SSTR2‑expressing tissues. NOTA‑Octreotide enables effective imaging of somatostatin receptor‑positive tumors in mice and shows high specific uptake in SSTR2‑expressing organs in healthy rats. NOTA-Octreotide can be used for PET imaging investigation of neuroendocrine tumors. .
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Cat. No.: HY-P11596
CAS No.: 3107808-75-0
Target:  

Integrin

Research Areas:  

Cancer

NOTA-Asp2-αvβ6L is an integrin αvβ6 binder with selective accumulation in αvβ6-positive pancreatic cancer cells and tumors. NOTA-Asp2-αvβ6L can be used as a PET/CT tracer for imaging pancreatic ductal adenocarcinoma (PDAC) .
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