NK224
NK224 is a peptide-based radiotracer targeting human PD-L1, with dual-radionuclide (68Ga and 18F) labeling compatibility enabled by the NOTA chelator. NK224 exhibits high binding affinity to PD-L1, with an IC50 value of 2.45 nM. NK224 visualizes intrapatient tumor heterogeneity and dynamically monitors PD-L1 target occupancy during immunotherapy. NK224 can be used for the study of non-small cell lung cancer (NSCLC).
For research use only. We do not sell to patients.
- Formula: C104H145N25O29S
- Molecular Weight:2241.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Chemical Information
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Molecular Weight 2241.48
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Formula C104H145N25O29S
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Sequence
cyclo-(Ac-Tyr-NMeAla-Asn-Pro-His-Glu-Hyp-Trp-Ser-{TrpNHOAc}-NMeNle-NMeNle-Lys-Cys)-Gly-NH2-NOTA
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Sequence Shortening
cyclo-{Ac-Y-{NMeAla}-NPHE-{Hyp}--{TrpNHOAc}-WS-{NMeNle-NMeNle}-KC}-G-NH2-NOTA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)