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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
PDZ+domain
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "PDZ+domain" in MCE Product Catalog:
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8 Publications Verification
Cat. No.: HY-P0117A
CAS No.: 1834571-04-8
Synonyms: Tat-NR2Bct TFA; NA-1 TFA
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4 Cited Publications
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NSC668036 is a Dishevelled (Dvl) PDZ domain inhibitor with a Kd of 237 μM. NSC668036 blocks Wnt signaling by interrupting the Frizzled-Dvl interaction .
Cat. No.: HY-102067
CAS No.: 294891-81-9
3289-8625 is an inhibitor of the PDZ domain of Dishevelled (Dvl) protein (Kd=10.6 μM) and has an inhibitory effect on Wnt signaling. In addition, 3289-8625 can slow the growth of prostate cancer PC-3 cells (IC50=12.5 μM). 3289-8625 can be used in the study of embryonic development and cancer .
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FSC231 is a PSD‐95/DLG/ZO‐1 (PDZ) domain inhibitor of PICK1. FSC231 has analgesic effects .
Cat. No.: HY-P10331
CAS No.: 2757292-12-7
Cat. No.: HY-P10226
CAS No.: 2717490-36-1
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Cat. No.: HY-P10212
CAS No.: 1786434-31-8
Synonyms: UCCB01-125
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Cat. No.: HY-P2298
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Cat. No.: HY-P2298A
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Cat. No.: HY-184410
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nNOS-PDZ-IN-1 is an orally active, blood-brain barrier-penetrant inhibitor of neuronal nitric oxide synthase-PDZ domain (nNOS-PDZ), with an IC50 of 0.76 μM and a KD of 0.55 μM. nNOS-PDZ-IN-1 binds to the nNOS-PDZ domain, occupies its binding site and disrupts its interaction with the serotonin transporter. nNOS-PDZ-IN-1 exhibits antidepressant activity without addiction potential or movement-related side effects. nNOS-PDZ-IN-1 can be used in research related to major depressive disorder .
Cat. No.: HY-P77130
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PDZD11; PDZ Domain-Containing Protein 11; Prev. PDZK11; AIPP1; Plasma Membrane Calcium ATPase-Interacting Single-PDZ Protein; PISP; PMCA-Interacting Single-PDZ Protein; PDZ Domain Containing 11; ATPase-Interacting PDZ Protein
Cat. No.: HY-182624
CAS No.: 873841-43-1
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FJ9 is a NHERF1/PDZ inhibitor with human NHERF1 PDZ1 IC50 1540 μM, NHERF1 PDZ2 IC50 160 μM, and Frizzled-7-Dishevelled PDZ complex Ki 10 μM. FJ9 binds ligand-binding pockets of NHERF1 PDZ domains to block cognate ligand interactions, disrupts Frizzled-7-Dishevelled interactions, and down-regulates canonical Wnt signaling. FJ9 induces apoptosis in cancer cells with intact β-catenin signaling. FJ9 can be used for the research of non-small cell lung cancer, melanoma .
Cat. No.: HY-184469
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DVL1/P-gp-IN-1 is a DVL1 inhibitor (lC50 of 0.97 μM) and a P-glycoprptein (P-gp) inhibitor. DVL1/P-gp-IN-1 specific binds to the PDZ domain of the DVL1 protein of the Wnt/β-catenin pathway and inhibition of the P-gp. DVL1/P-gp-IN-1 reduces β-catenin expression, suppresses colon cancer cells proliferation, and induces apoptosis both in vitro and in xenograft models. DVL1/P-gp-IN-1 can be used in colorectal cancer research .
Cat. No.: HY-180197
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PICK1 PDZ-IN-1 (Compound 6b) is a selective and brain-penetrant protein interacting with C kinase 1 (PICK1) PDZ domain inhibitor with a Ki of 27.73 μM. PICK1 PDZ-IN-1 can competitively inhibit the interaction between PICK1 and the GluA2 subunit of AMPA receptors. PICK1 PDZ-IN-1 can increase the survival rate of HT22 cells and primary cortical neuron cells induced by glutamate and inhibit ROS production. PICK1 PDZ-IN-1 exhibits neuroprotective effect and reduces the area of cerebral infarction. PICK1 PDZ-IN-1 can be used for the research of ischemic stroke .
Cat. No.: HY-P76838
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CNKSR3; FLJ31349; Prev. MAGI1; Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 1; Connector Enhancer Of Kinase Suppressor Of Ras 3; Membrane Associated Guanylate Kinase Interacting Protein-Like 1; Connector Enhancer Of KSR 3; Membrane-A
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Cat. No.: HY-P87983
Synonyms: CAP70, NHERF3, PDZD1, PDZK1, Na(+)/H(+) exchange regulatory cofactor NHE-RF3, NHERF-3, CFTR-associated protein of 70 kDa, Na(+)/H(+) exchanger regulatory factor 3, Na/Pi cotransporter C-terminal-associated protein 1, PDZ domain-containing protein 1, Sodium-hydrogen exchanger regulatory factor 3, NaPi-Cap1
Cat. No.: HY-P86953
Synonyms: A; IP : 3 antibody; AIP-3 antibody; AIP3 antibody; Atrophin 1 interacting protein 3 antibody; Atrophin-1-interacting protein 3 antibody; BAI1 associated protein 1 antibody; BAI1-associated protein 1 antibody; BAIAP 1 antibody; BAIAP1 antibody; BAP 1 antibody; A; IP : 3 antibody; AIP-3 antibody; AIP3 antibody; Atrophin 1 interacting protein 3 antibody; Atrophin-1-interacting protein 3 antibody; BAI1 associated protein 1 antibody; BAI1-associated protein 1 antibody; BAIAP 1 antibody; BAIAP1 antibody; BAP 1 antibody; BAP-1 antibody; BAP1 antibody; Gukmi1 antibody; MAGI 1 antibody; MAGI-1 antibody; MAGI1 antibody; MAGI1_HUMAN antibody; MAGI1c antibody; Membrane associated guanylate kinase inverted 1 antibody; membrane associated guanylate kinase WW and PDZ domain containing 1 antibody; Membrane-associated guanylate kinase antibody; Membrane-associated guanylate kinase inverted 1 antibody; TNRC 19 antibody; TNRC19 antibody; Trinucleotide repeat containing gene 19 antibody; Trinucleotide repeat containing gene 19 protein antibody; Trinucleotide repeat-containing gene 19 protein antibody; WW and PDZ domain-containing protein 1 antibody; WW domain containing protein 3 antibody; WW domain-containing protein 3 antibody; WWP 3 antibody; WWP3 antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
