2717490-36-1
Chemical Structure
PGD97
- CAS No.: 2717490-36-1
- Formula:C74H111N23O14S3
- Molecular Weight:1643.01
InChIKey: SJMCWKDUVMZJMI-ZMHOLRAJSA-N
SMILES: O=C(N1[C@](CCCC1)([H])C(N[C@@H](C(C)(SSC[C@@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2)=O)CC3=CC4=C(C=CC=C4)C=C3)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)NC(C)=O)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)C(C)(C)C)=O)=O)=O)=O)[C@@H]2CC5=CSC6=CC=CC=C56
Biological Activity: PGD97 is a selective cyclic peptide inhibitor against CAL/CFTR interactions, with a KD value of 6 nM towards the CAL PDZ domain for its desulfide cyclized form. PGD97 (desulfide cyclized form) has selectivity ≥ 130-fold compared to NHERF1/2 PDZ domains. PGD97 is capable of stabilizing F508del-CFTR at the cell membrane and improving CFTR function required for proper fluid homeostasis in tne lung. PGD97 can be used for the research of cystic fibrosis[1].
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PGD97 | PGD97 is a selective cyclic peptide inhibitor against CAL/CFTR interactions, with a KD value of 6 nM towards the CAL PDZ domain for its desulfide cyclized form. PGD97 (desulfide cyclized form) has selectivity ≥ 130-fold compared to NHERF1/2 PDZ domains. PGD97 is capable of stabilizing F508del-CFTR at the cell membrane and improving CFTR function required for proper fluid homeostasis in tne lung. PGD97 can be used for the research of cystic fibrosis. | |||||||||||||||||||||
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Keywords
