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PS1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (4) Apoptosis (3) Aryl Hydrocarbon Receptor (3) Bcl-2 Family (2) Biochemical Assay Reagents (3) Caspase (1) CDK (1) Dopamine Transporter (1) Drug Derivative (1) Environmental Pollutants (1) Ferroptosis (2) Glutathione Peroxidase (2) GPR39 (1) IAP (1) Interleukin Related (1) Isotope-Labeled Compounds (2) Liposome (1) LPL Receptor (1) Monoamine Oxidase (1) NADPH Oxidase (2) NF-κB (1) OGA (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Small Interfering RNA (siRNA) (2) STAT (1) Survivin (1) Tau Protein (1) TRP Channel (1) VEGFR (1) γ-secretase (4)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Inflammation/Immunology (4) Neurological Disease (13)
Oligonucleotides:	Phospholipids (2) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W011338

Benzyl butyl phthalate 1 Publications Verification	Environmental Pollutants Aryl Hydrocarbon Receptor	Cancer
Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) ^[1] .

HY-126213

1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium 18:1 Lyso-PS	NADPH Oxidase Interleukin Related Apoptosis	Inflammation/Immunology
Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product generated following NADPH oxidase activation and Lyso-PS signal transduction. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium signals through macrophage G2A to enhance the phagocytic uptake of PS-dependent apoptotic (apoptosis) neutrophils and PS-exposed activated neutrophils. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium enhances macrophage phagocytic uptake of apoptotic cells, carboxylate-modified microspheres, and PS-exposed non-apoptotic activated neutrophils. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium serves as an acyl acceptor substrate for the lysophosphatidyltransferase At1g78690p to generate diacylphosphatidylserine. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium reduces the secretion of IL-8 and decreases the proportion of viable colon cancer cells. 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium is applicable to studies on peritonitis and inflammatory bowel disease ^[1] .

HY-P5381

gp91 ds-tat 1 Publications Verification	NADPH Oxidase Ferroptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase TRP Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
gp91 ds-tat, a biological active peptide, is a NADPH oxidase 2 (Nox2) inhibitor. gp91 ds-tat blocks NADPH oxidase-dependent superoxide production. gp91 ds-tat ameliorates high glucose-induced increase in total ROS, LPOs and iron levels. gp91 ds-tat inhibits homocysteine (Hcy)-induced activation of NLRP3 inflammasomes and restores Hcy-inhibited lysosomal TRPML1 channel activity. gp91 ds-tat improves cerebrovascular and cognitive function in APP/PS1 mice. gp91 ds-tat can be used for the study of Alzheimer’s disease (AD), glomerular inflammation and cardiovascular disease ^[1] .

HY-119165

GSM-1	γ-secretase	Neurological Disease
GSM-1 is a potent γ-secretase modulator. GSM-1 directly targets the transmembrane domain (TMD) 1 of presenilin 1 (PS1) ^[1] .

HY-147072

1-Stearoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine sodium 18:0 -18:2 PS	Liposome	Others
1-Stearoyl-2-linoleoyl-sn-glycero-3-phospho-L-serine sodium is a glycerophospholipid ^[1].

HY-W011338S

Benzyl butyl phthalate-d4	Aryl Hydrocarbon Receptor	Cancer
Benzyl butyl phthalate-d₄ is the deuterium labeled Benzyl butyl phthalate ^[1]. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

HY-50882

ELN318463	γ-secretase	Neurological Disease
ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC₅₀s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN318463 is 51-fold more selective for PS1 ^[1] .

HY-161723

LH2-051	Dopamine Transporter CDK	Neurological Disease
LH2-051, a lysosome-enhancing compound (LYEC), is a brain-penetrant dopamine transporter (DAT) inhibitor (K_i: 0.95 μM). LH2-051 inhibits DAT-mediated dopamine uptake with an IC₅₀ of 3.0 μM. LH2-051 promotes nuclear translocation of TFEB and lysosome biogenesis. LH2-051 improves the memory of amyloid precursor protein (APP)/Presenilin 1 (PS1) mice. LH2-051 can be used for the study of Alzheimer’s disease ^[1].

HY-N3001

Isolinderalactone 1 Publications Verification	STAT VEGFR Bcl-2 Family Survivin IAP NF-κB Apoptosis Caspase	Neurological Disease Inflammation/Immunology Cancer
Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury ^[1] .

HY-139973

OAB-14	Amyloid-β	Neurological Disease
OAB-14, is a Bexarotene (HY-14171) derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. OAB-14 effectively ameliorates the dysfunction of the endosomal-autophagic-lysosomal pathway in APP/PS1 transgenic mice ^[1] .

HY-N1414A

3′,6-Disinapoylsucrose 2 Publications Verification	Bcl-2 Family Apoptosis	Neurological Disease
3′,6-Disinapoylsucrose is a type of oligosaccharide that's effective when taken orally, and it has antidepressant, anti-anxiety, and antioxidant properties. 3′,6-Disinapoylsucrose inhibits neuronal apoptosis by lowering the ratio of Bax to Bcl-2 in hippocampal neurons, and it enhances cognitive function in APP/PS1 transgenic mice by activating the CREB/BDNF signaling pathway ^[1] .

HY-157623

16:0 Lyso PS 1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium	Biochemical Assay Reagents	Others
16:0 Lyso PS (1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium) is a lysophospholipid. 16:0 Lyso PS serves as a standard for preparing standard curves ^[1].

HY-50882A

ELN318463 racemate	γ-secretase	Neurological Disease
ELN318463 racemate is the racemate of ELN318463. ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC₅₀s of 12nM and 656 nM for PS1and PS2, respectively. ELN318463 is 51-fold more selective for PS1 ^[1] .

HY-176271

MAO-B-IN-45	Ferroptosis Monoamine Oxidase Glutathione Peroxidase Reactive Oxygen Species (ROS) Tau Protein Amyloid-β	Neurological Disease
MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. MAO-B-IN-45 shows selectivity towards MAO-B with an IC₅₀ of 87.47 nM and selectivity exceeding 229-fold for MAO-B over MAO-A. MAO-B-IN-45 has excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro. MAO-B-IN-45 improves cognitive and behavioral impairments in 3×Tg (APP/Tau/Ps1) AD mouse and significantly reduced the levels of ferritin heavy chain 1 (FTH1), APP, and Tau phosphorylation (p-Tau) proteins in the brain.

HY-118243

KMS88009	Amyloid-β	Others
KMS88009 is a potent small molecule that directly interferes with the formation of amyloid-β oligomers, thereby preserving cognitive behavior when used preventively and reversing cognitive behavior decline when used therapeutically. Oral administration of KMS88009 around the onset of Alzheimer's disease symptoms significantly reduced the assembly of amyloid-β oligomers and improved cognitive behavior in the APP/PS1 double transgenic mouse model. This unique dual mode of action suggests that KMS88009 may be a powerful therapeutic candidate for the treatment of Alzheimer's disease. In an evaluation, the physicochemical properties, pharmacokinetics and toxicity of this anti-amyloidogenic small molecule KMS88009 were studied, as well as post-mortem analysis of APP/PS1 TG mice after behavioral testing.

HY-161953

O-GlcNAcase-IN-2	OGA	Neurological Disease
O-GlcNAcase-IN-2 (compound 81) is an orally effective, blood-brain barrier-permeable OGA inhibitor (IC₅₀=4.93 nM). O-GlcNAcase-IN-2 can increase the O-GlcNAcylation level of proteins and phosphorylation of tau (p-Ser199, p-Thr205 and p-Ser396) in the OA-damaged SH-SY5Y cell model. O-GlcNAcase-IN-2 can also improve cognitive impairment in APP/PS1 mice and has potential anti-Alzheimer's disease (AD) effects ^[1].

HY-W011338R

Benzyl butyl phthalate (Standard)	Reference Standards Aryl Hydrocarbon Receptor	Cancer
Benzyl butyl phthalate (Standard) is the analytical standard of Benzyl butyl phthalate. This product is intended for research and analytical applications. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) ^[1] .

HY-123761

L505-yne	γ-secretase	Neurological Disease
L505-yne is an active site-directed γ-secretase inhibitor. L505-yne blocks photoaffinity labeling of *PS1-NTF, PS1-CTF, and SPP* by clickable GSI photoprobes, binds the γ-secretase complex and inhibits Aβ42 production. L458-BPyne can be used for the research of Alzheimer’s disease ^[1] .

HY-RS11276

PSEN1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PSEN1 Human Pre-designed siRNA Set A contains three designed siRNAs for PSEN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PSEN1 Human Pre-designed siRNA Set A PSEN1 Human Pre-designed siRNA Set A

HY-18157

SCH 900229	Amyloid-β	Neurological Disease
SCH 900229 is a potent γ-secretase inhibitor with selective activity against PS1. The Aβ40 IC50 value of SCH 900229 is 1.3 nM, showing its excellent ability in reducing Aβ. SCH 900229 has shown good Aβ-lowering effects after oral administration in preclinical animal models. SCH 900229 has been advanced to human clinical trials for further development of compounds for the inhibition of Alzheimer's disease ^[1].

HY-143675S

1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS-d9	Isotope-Labeled Compounds	Others
1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS-d₉ is the deuterium labeled 1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS .

HY-167592S

17:0-20:3 PS-d5 1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(d5)-3-phospho- L-serine sodium	Isotope-Labeled Compounds	Others
17:0-20:3 PS-d₅ (1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(d₅)-3-phospho- L-serine (sodium)) is deuterium labeled 17:0-20:3 PS .

HY-182367

TMN-OMe	GPR39	Neurological Disease
TMN-OMe is a blood-brain barrier-permeable GPR39 agonist and a radiotracer for positron emission tomography (PET). TMN-OMe activates GPR39 by recruiting β-arrestin, exhibits highly selective binding ability in the mouse brain, and enables quantitative analysis of GPR39 at the in vivo level. TMN-OMe shows specific uptake in GPR39 knockout mice, Alzheimer's disease model (APP/PS1) mice, and blocking experiments. TMN-OMe facilitates in-depth exploration of changes in GPR39-related mechanisms in neurological diseases and is widely used in Alzheimer's disease research ^[1].

HY-RS18076

Psen1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Psen1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Psen1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Psen1 Mouse Pre-designed siRNA Set A Psen1 Mouse Pre-designed siRNA Set A

HY-164231A

18:0,20:4 PS sodium 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-L-serine sodium; SAPS (18:0/20:4(5Z,8Z,11Z,14Z)) sodium	Biochemical Assay Reagents	Others
18:0,20:4 PS (1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-L-serine) sodium can be incorporated into RNA particles that act as RNA delivery vehicles for in vivo application, facilitating delivery of RNA to target tissues ^[1].

HY-164231

18:0,20:4 PS 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-L-serine; SAPS (18:0/20:4(5Z,8Z,11Z,14Z))	Biochemical Assay Reagents	Others
18:0,20:4 PS (1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-L-serine) is a phosphatidylserine component for RNA particle formulations. 18:0,20:4 PS can be used as RNA delivery vehicles ^[1].

HY-14371

LX2932	Drug Derivative LPL Receptor	Inflammation/Immunology
LX2932 is an orally active LX2931 (HY-14370) analogue and *S1P/S1PR* signaling axis modulator. LX2932 yields a dose-dependent decrease in circulating lymphocyte numbers. LX2932 improves collagen-induced arthritis ^[1] .

16:0 Lyso PS 1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium	Biochemical Assay Reagents
16:0 Lyso PS (1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium) is a lysophospholipid. 16:0 Lyso PS serves as a standard for preparing standard curves ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P5381

gp91 ds-tat 1 Publications Verification	NADPH Oxidase Ferroptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase TRP Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
gp91 ds-tat, a biological active peptide, is a NADPH oxidase 2 (Nox2) inhibitor. gp91 ds-tat blocks NADPH oxidase-dependent superoxide production. gp91 ds-tat ameliorates high glucose-induced increase in total ROS, LPOs and iron levels. gp91 ds-tat inhibits homocysteine (Hcy)-induced activation of NLRP3 inflammasomes and restores Hcy-inhibited lysosomal TRPML1 channel activity. gp91 ds-tat improves cerebrovascular and cognitive function in APP/PS1 mice. gp91 ds-tat can be used for the study of Alzheimer’s disease (AD), glomerular inflammation and cardiovascular disease ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3001

Isolinderalactone 1 Publications Verification	Classification of Application Fields Terpenoids Sesquiterpenes Plants Lauraceae Lindera aggregata (Sims) Kosterm. Disease Research Fields Source Classification Cancer	STAT VEGFR Bcl-2 Family Survivin IAP NF-κB Apoptosis Caspase
Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury ^[1] .

HY-N1414A

3′,6-Disinapoylsucrose 2 Publications Verification	Natural Products Polymer products Plants Brassicaceae Raphanus sativus Linn.	Bcl-2 Family Apoptosis
3′,6-Disinapoylsucrose is a type of oligosaccharide that's effective when taken orally, and it has antidepressant, anti-anxiety, and antioxidant properties. 3′,6-Disinapoylsucrose inhibits neuronal apoptosis by lowering the ratio of Bax to Bcl-2 in hippocampal neurons, and it enhances cognitive function in APP/PS1 transgenic mice by activating the CREB/BDNF signaling pathway ^[1] .

Cat. No.	Product Name	Chemical Structure

HY-W011338S

Benzyl butyl phthalate-d4
Benzyl butyl phthalate-d₄ is the deuterium labeled Benzyl butyl phthalate ^[1]. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

Benzyl butyl phthalate-d4

Benzyl butyl phthalate-d₄ is the deuterium labeled Benzyl butyl phthalate ^[1]. Benzyl butyl phthalate, a member of phthalic acid esters (PAEs), can trigger the migration and invasion of hemangioma (HA) cells via upregulation of Zeb1. Benzyl butyl phthalate activates aryl hydrocarbon receptor (AhR) in breast cancer cells to stimulate SPHK1/S1P/S1PR3 signaling and enhances formation of metastasis-initiating breast cancer stem cells (BCSCs) .

HY-143675S

1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS-d9
1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS-d₉ is the deuterium labeled 1-Palmitoyl-2-palmitoyl-sn-glycero-3-PS .

HY-167592S

17:0-20:3 PS-d5
17:0-20:3 PS-d₅ (1-Heptadecanoyl-2-eicosatrienoyl-sn-glycero(d₅)-3-phospho- L-serine (sodium)) is deuterium labeled 17:0-20:3 PS .

Host:	Mouse (1) Rabbit (4)
Reactivity:	Human (5) Rat (3) Mouse (3)
Application:	IHC-P (1) ICC/IF (3) IP (2) WB (5)
Isotype:	IgG (4) IgG1 (1)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Phosphorylated (1) Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82123

	Phospho-Presenilin 1 (Ser310) Antibody (YA1868) PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182	WB	Human
	Phospho-Presenilin 1 (Ser310) Antibody (YA1868) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Presenilin 1 (Ser310).

HY-P82123A

	Phospho-Presenilin 1 (Ser310) Antibody (YA1868)(PBS only) PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182	WB	Human
	Phospho-Presenilin 1 (Ser310) Antibody (YA1868) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Presenilin 1 (Ser310).

HY-P81977

	Presenilin 1 Antibody (YA1722) PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182	WB, ICC/IF, IP	Human, Mouse, Rat
	Presenilin 1 Antibody (YA1722) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Presenilin 1.

HY-P81977A

	Presenilin 1 Antibody (YA1722)(PBS only) PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182	WB, ICC/IF, IP	Human, Mouse, Rat
	Presenilin 1 Antibody (YA1722) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Presenilin 1.

HY-P80438

	Beta Actin Antibody (YA823) 5+ Cited Publications A26C1A antibody; A26C1B antibody; ACTB antibody; ACTB_HUMAN antibody; Actin beta antibody; Actin cytoplasmic 1 antibody; Actin, cytoplasmic 1, N-terminally processed antibody; Actx antibody; b actin antibody; Beta cytoskeletal actin antibody; Beta-actin antibody; BRWS1 antibody; E430023M04Rik antibody; MGC128179 antibody; PS1TP5 binding protein 1 antibody; PS1TP5BP1 antibody; β-actin antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Beta Actin Antibody is a non-conjugated and Mouse origined IgG1 monoclonal antibody, targeting to Beta Actin. It can be used as a loading control antibody.

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