2. Neuronal Signaling
  3. Amyloid-β
  4. OAB-14

OAB-14, is a Bexarotene (HY-14171) derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. OAB-14 effectively ameliorates the dysfunction of the endosomal-autophagic-lysosomal pathway in APP/PS1 transgenic mice.

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OAB-14 Chemical Structure

OAB-14 Chemical Structure

CAS No. : 2140911-49-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 385 In-stock
Solution
10 mM * 1 mL in DMSO USD 385 In-stock
Solid
5 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

OAB-14 Related Antibodies

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Description

OAB-14, is a Bexarotene (HY-14171) derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. OAB-14 effectively ameliorates the dysfunction of the endosomal-autophagic-lysosomal pathway in APP/PS1 transgenic mice[1][2].

In Vivo

OAB-14 significantly alleviates cognitive impairments in amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic mice after administration for 15 days or 3 months. OAB-14 rapidly cleared 71% of Aβ by promoting microglia phagocytosis and increasing IDE and NEP expression. OAB-14 also attenuates the downstream pathological events of Aβ accumulation, such as synaptic degeneration, neuronal loss, tau hyperphosphorylation and neuroinflammation in APP/PS1 mice. OAB-14 has no significant effect on body weight or liver toxicity after acute and chronic treatment[1].
OAB-14 facilitates receptor-mediated endocytosis and restores autophagy flux via the AMPK/mTOR pathway. OAB-14 enhances the lysosomal activity, and reduced Aβ accumulation in lysosomes is observed in OAB-14-treated AD mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

518.73

Formula

C32H46N4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCN)NC1=CC=C(C(NC2=C(C(C)(CCC3(C)C)C)C3=CC4=C2C(C)(C)CCC4(C)C)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (38.56 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9278 mL 9.6389 mL 19.2779 mL
5 mM 0.3856 mL 1.9278 mL 3.8556 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9278 mL 9.6389 mL 19.2779 mL 48.1946 mL
5 mM 0.3856 mL 1.9278 mL 3.8556 mL 9.6389 mL
10 mM 0.1928 mL 0.9639 mL 1.9278 mL 4.8195 mL
15 mM 0.1285 mL 0.6426 mL 1.2852 mL 3.2130 mL
20 mM 0.0964 mL 0.4819 mL 0.9639 mL 2.4097 mL
25 mM 0.0771 mL 0.3856 mL 0.7711 mL 1.9278 mL
30 mM 0.0643 mL 0.3213 mL 0.6426 mL 1.6065 mL
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OAB-14 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OAB-142140911-49-3OAB14OAB 14Amyloid-ββ-amyloid peptideAβAbetaAlzheimer’s diseasecognitiveamyloid-βclearanceendosomal-autophagic-lysosomalmemory impairmentInhibitorinhibitorinhibit

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