851600-86-7
851600-86-7
Chemical Structure
ELN318463
- CAS No.: 851600-86-7
- Formula:C19H20BrClN2O3S
- Molecular Weight:471.80
IUPAC Name: (R)-N-(4-bromobenzyl)-4-chloro-N-(2-oxoazepan-3-yl)benzenesulfonamide
InChIKey: KTCJYACFOQWRDO-GOSISDBHSA-N
SMILES: O=S(N(CC1=CC=C(Br)C=C1)[C@H]2C(NCCCC2)=O)(C(C=C3)=CC=C3Cl)=O
Biological Activity: ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN318463 is 51-fold more selective for PS1[1][2].
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ELN318463 | 99.45% | ELN318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN318463 is 51-fold more selective for PS1. | ||||||||||||||||||||
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References
- [1]. Zhao B, et al. Identification of gamma-secretase inhibitor potency determinants on presenilin. J Biol Chem. 2008 Feb 1;283(5):2927-38. [Content Brief]
- [2]. Basi GS, et al. Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease. Alzheimers Res Ther. 2010 Dec 29;2(6):36. [Content Brief]
