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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
Pantothenate
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "Pantothenate" in MCE Product Catalog:
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6 Publications Verification
Synonyms: Calcium Pantothenate; Calcium D-Pantothenate; Vitamin B5 calcium salt
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6 Publications Verification
Synonyms: Sodium Pantothenate; Vitamin B5 sodium
Category:
Alkaloids Other Alkaloids Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
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4 Cited Publications
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PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively .
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2 Cited Publications
Cat. No.: HY-44170
CAS No.: 902614-04-4
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Pantothenate kinase-IN-2 is a pantothenate kinase inhibitor with IC50 values of 92 nM for PanK2, 70 nM for PanK1β, and 25 nM for PanK3. Pantothenate kinase-IN-2 can bind specifically to the ATP-PanK3 complex and block CoA biosynthesis. Pantothenate kinase-IN-2 can be used for the research of pank-associated neurodegeneration and type 2 diabetes .
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HOPan is a PanK substrate and Pantothenate (HY-B0430) analog. HOPan inhibits CoA levels .
Cat. No.: HY-144734
CAS No.: 1024168-48-6
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Pantothenate kinase-IN-1 is a PANK3 inhibitor with an IC50 of 0.51 μM. Pantothenate kinase-IN-1 acts as a pantothenate-competitive inhibitor, which occupies the pantothenate-binding site of PANK3 and binds to both protomers in the PANK3 dimer. Pantothenate kinase-IN-1 exhibits metabolic stability in mouse and rat plasma. Pantothenate kinase-IN-1 can be used in the research of pantothenate kinase-associated neurodegenerative diseases and metabolic diseases .
Cat. No.: HY-159509
CAS No.: 2361124-03-8
Synonyms: Claziprotamide; BBP-671
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Claziprotamidum (Claziprotamide; BBP-671) is a panthothenate kinase (PANK) activator with oral activity and blood-brain barrier permeability. Claziprotamidum binds to and activates all PANK isoforms, with the highest affinity for PANK3 (KD = 97 pM; IC50 = 1.39 nM). Claziprotamidum increases the intracellular biosynthesis of Coenzyme A (HY-128851) and restores mitochondrial function. Claziprotamidum can be used in the research of pantothenate kinase-associated neurodegeneration and propionic acidemia .
Cat. No.: HY-109033
CAS No.: 1858268-66-2
Synonyms: RE-024
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Fosmetpantotenate is a phosphopantothenic acid (PPA) precursor designed to release PPA intracellularly, leading to restoration of CoA levels. Fosmetpantotenate is used to research pantothenate kinase-associated neurodegeneration.
Cat. No.: HY-169491
CAS No.: 1224691-12-6
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Pantothenate-AMC is a fluorogenic substrate used for detecting the enzymatic activity of vanin-1, an enzyme involved in the recycling of L-pantothenic acid. Upon enzymatic cleavage by vanin-1, 7-amino-7-methylcoumarin (AMC) is released, and its fluorescence can be used to quantify vanin-1 activity. The excitation/emission maxima of AMC are 340-360 nm and 440-460 nm, respectively .
Synonyms: Pantothenate-13C3,15N; Vitamin B5-13C3,15N hemicalcium hemihydrate
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Cat. No.: HY-164909
CAS No.: 2170608-85-0
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PZ-3022 is an orally active allosteric agonist of pantothenate kinase (PanK) with an EC50 of 5.3 nM against PanK3. PZ-3022 antagonizes the inhibitory effect of C3-CoA. PZ-3022 increases CoA levels in cells and the liver, upregulates CoASH and C2-CoA, downregulates C3-CoA, and restores impaired TCA cycle and mitochondrial function. PZ-3022 can be used for the research of propionic acidemia and metabolic CoA deficiency .
Synonyms: Calcium Pantothenate (Standard); Calcium D-Pantothenate (Standard); Vitamin B5 calcium salt (Standard)
Cat. No.: HY-W579377
CAS No.: 60979-68-2
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Pantoic acid sodium is an intermediate in the bacterial coenzyme A biosynthetic pathway. Pantoic acid sodium is produced via hydroxymethylation of α-ketoisovaline followed by reduction. Pantoic acid sodium can condense with β-Alanine (HY-N0230) to form vitamin B5 .
Cat. No.: HY-W399035
CAS No.: 1112-33-0
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Pantoic acid is an intermediate in the bacterial coenzyme A biosynthetic pathway. Pantoic acid is produced via hydroxymethylation of α-ketoisovaline followed by reduction. Pantoic acid can condense with β-Alanine (HY-N0230) to form vitamin B5 .
Cat. No.: HY-B1028R
CAS No.: 16816-67-4
Synonyms: D-Pantethine (Standard); LBF disulfide (Standard)
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Cat. No.: HY-B0430AR
CAS No.: 867-81-2
Synonyms: Sodium Pantothenate (Standard); Vitamin B5 sodium (Standard)
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Allantoin calcium pantothenate is a complex formed by Allantoin (HY-N0543) and Calcium pantothenate (HY-N0681). Allantoin calcium pantothenate has protective, anti-irritant, soothing and moisturizing properties. Allantoin calcium pantothenate can be safely used as an anti-irritant, wound healing agent and conditioning agent. Allantoin calcium pantothenate can be incorporated at 0.2-2% in most formulations. Allantoin calcium pantothenate can be used in cosmetics-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
