6 Results for "

Phe43 cavity

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "Phe43 cavity" in MCE Product Catalog:

BNM-III-170
BNM-III-170
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Cat. No.: HY-115488A
CAS No.: 1859189-55-1
Target:  

HIV

Research Areas:  

Infection

BNM-III-170, CD4-mimeticcompound, is an anti-HIV-1 agent. BNM-III-170 binds to the Phe43 cavity of HIV 1 gp120. BNM-III-170 can inhibits HIV-1 viral entry into target cells. BNM-III-170 can be used for the research of HIV-1 infection .
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Indoline (Standard)
Indoline (Standard)
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Cat. No.: HY-Y0788R
CAS No.: 496-15-1
Indoline (Standard) is an analytical standard for Indoline (HY-Y0788). This product is intended for research and analytical applications. Indoline is a HIV-1 envelope glycoprotein gp120 binder. Indoline binds to the conserved CD4-binding site of gp120 (the Phe 43 cavity and its surrounding vestibule), competitively blocks the binding of CD4, and prematurely triggers conformational changes of the Env trimer, resulting in viral inactivation. Indoline induces the conformational opening of HIV-1 Env on infected cells, exposes vulnerable epitopes, increases antibody recognition rate, enhances the binding of FcγRIIIa receptors, and sensitizes infected cells to antibody-dependent cellular cytotoxicity. Indoline is a derivative of Indole (HY-W001132). Indoline can be used in studies related to HIV-1 infection .
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NBD-11021
NBD-11021
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Cat. No.: HY-117855
CAS No.: 1427304-84-4
Target:  

HIV

Research Areas:  

Infection

NBD-11021 is a HIV-1 entry antagonist and CD4 antagonist. NBD-11021 binds to the Phe43 cavity of HIV-1 gp120 and competitively blocks the gp120-CD4 interaction . NBD-11021 exhibits broad-spectrum inhibitory activity against 56 HIV-1 Env pseudoviruses of different subtypes, with an IC50 of 0.6-5.3 μM. NBD-11021 inhibits CCR5- and CXCR4-tropic HIV-1, primary HIV-1, drug-resistant HIV-1, HIV-1 Env-mediated cell fusion and intercellular viral transmission. NBD-11021 can be used in studies related to HIV-1 gp120, viral entry and HIV infection .
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BNM-III-170 free base
BNM-III-170 free base
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Cat. No.: HY-115488
CAS No.: 1859189-54-0
Target:  

HIV

Research Areas:  

Infection

BNM-III-170 free base, CD4-mimeticcompound, is an anti-HIV-1 agent. BNM-III-170 free base, binds to the Phe43 cavity of HIV 1 gp120. BNM-III-170 can inhibits HIV-1 viral entry into target cells. BNM-III-170 free base, can be used for the research of HIV-1 infection .
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DMJ-I-228
DMJ-I-228
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Cat. No.: HY-121820
CAS No.: 1374035-59-2
Target:  

HIV

Research Areas:  

Infection

DMJ-I-228 is a CD4-mimetic. DMJ-I-228 binds to HIV-1 gp120 within the conserved Phe 43 cavity near the CD4-binding site, thereby blocking CD4 binding and inhibiting HIV-1 infection .
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JRC-I-191
JRC-I-191
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Cat. No.: HY-182376
CAS No.: 1098209-30-3
Target:  

HIV

Research Areas:  

Infection

JRC-I-191 is an anti-HIV-1 agent. JRC-I-191 inhibits HIV-1 YU-2 entry into cells. JRC-I-191 does not inhibit infection of cells by amphotropic murine leukemia virus. JRC-I-191 can be used for the research of HIV-1 infection .
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