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Cat. No.: HY-115488

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BNM-III-170 free base

BNM-III-170 free base, CD4-mimeticcompound, is an anti-HIV-1 agent. BNM-III-170 free base, binds to the Phe43 cavity of HIV 1 gp120. BNM-III-170 can inhibits HIV-1 viral entry into target cells. BNM-III-170 free base, can be used for the research of HIV-1 infection.

For research use only. We do not sell to patients.

CAS No.: 1859189-54-0
Formula: C₂₁H₂₄ClFN₆O₂
Molecular Weight:446.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BNM-III-170 free base Chemical Structure

CAS No.: 1859189-54-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
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Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HIV-1

All HIV Isoforms :

In Vitro

BNM-III-170 free base, inhibits HIV 1 JR FL strain entry into Cf2Th CD4/CCR5 cells with an IC₅₀ of 14.5 μM^[1].
BNM-III-170 free base, inhibts various HIV-1 viral strains with IC₅₀ values of 9-200 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1859189-54-0
Molecular Weight 446.91
Formula C₂₁H₂₄ClFN₆O₂
SMILES

N(C(C(NC1=CC(F)=C(Cl)C=C1)=O)=O)[C@H]2C=3C(C[C@@H]2CNC(=N)N)=CC(CNC)=CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fritschi CJ, et al. Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics. ACS Med Chem Lett. 2021 Oct 29;12(11):1824-1831. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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BNM-III-170 free base

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BNM-III-170 free base Related Classifications

HY-115488 Related Classifications