BNM-III-170
Based on 1 Customer Validation
BNM-III-170, CD4-mimeticcompound, is an anti-HIV-1 agent. BNM-III-170 binds to the Phe43 cavity of HIV 1 gp120. BNM-III-170 can inhibits HIV-1 viral entry into target cells. BNM-III-170 can be used for the research of HIV-1 infection.
For research use only. We do not sell to patients.
- Purity : 98.48%
- CAS No.: 1859189-55-1
- Formula: C25H26ClF7N6O6
- Molecular Weight:674.95
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
|
HIV-1 |
In Vitro
BNM-III-170 inhibits HIV 1 JR FL strain entry into Cf2Th CD4/CCR5 cells with an IC50 of 14.5 μM[1].
BNM-III-170 inhibts various HIV-1 viral strains with IC50 values of 9-200 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 1859189-55-1
-
Appearance Solid
-
Molecular Weight 674.95
-
Formula C25H26ClF7N6O6
-
Color White to off-white
-
SMILES
O=C(NC1=CC=C(Cl)C(F)=C1)C(N[C@@H]2[C@@H](CNC(N)=N)CC3=C2C=CC(CNC)=C3)=O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (74.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
-
Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4816 mL | 7.4080 mL | 14.8159 mL | 37.0398 mL |
| 5 mM | 0.2963 mL | 1.4816 mL | 2.9632 mL | 7.4080 mL | |
| 10 mM | 0.1482 mL | 0.7408 mL | 1.4816 mL | 3.7040 mL | |
| 15 mM | 0.0988 mL | 0.4939 mL | 0.9877 mL | 2.4693 mL | |
| 20 mM | 0.0741 mL | 0.3704 mL | 0.7408 mL | 1.8520 mL | |
| 25 mM | 0.0593 mL | 0.2963 mL | 0.5926 mL | 1.4816 mL | |
| 30 mM | 0.0494 mL | 0.2469 mL | 0.4939 mL | 1.2347 mL | |
| 40 mM | 0.0370 mL | 0.1852 mL | 0.3704 mL | 0.9260 mL | |
| 50 mM | 0.0296 mL | 0.1482 mL | 0.2963 mL | 0.7408 mL | |
| 60 mM | 0.0247 mL | 0.1235 mL | 0.2469 mL | 0.6173 mL |
BNM-III-170 Related Classifications
HY-115488A Related Classifications
Powered by Bioz