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Isoforms Recommended:	RNA Polymerases

Results for "

RNA polymerase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (215) PARP (1) ADC Linkers (1) ADC Payloads (6) Akt (1) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (28) Apoptosis (42) Arenavirus (2) ATM/ATR (1) ATP Synthase (1) Aurora Kinase (1) Autophagy (3) Bacterial (45) Bcl-2 Family (2) Biochemical Assay Reagents (5) Branched Chain Amino Acid Transaminase (BCAT) (1) c-Myc (2) Calcium Channel (1) CDK (33) CHIKV (5) Cyclic GMP-AMP Synthase (1) Cytochrome P450 (1) Dengue Virus (5) Deubiquitinase (2) DNA Alkylator/Crosslinker (3) DNA Methyltransferase (1) DNA Stain (4) Drug Derivative (3) Drug Intermediate (3) Drug Isomer (4) Drug Metabolite (11) Drug-Linker Conjugates for ADC (4) Endogenous Metabolite (18) Enterovirus (5) Environmental Pollutants (1) ERK (1) Filovirus (2) Flavivirus (4) Fluorescent Dye (3) Fungal (6) G-quadruplex (2) GLUT (2) HCV (41) HCV Protease (7) Histone Methyltransferase (1) HIV (8) HIV Protease (3) HMG-CoA Reductase (HMGCR) (2) HSV (2) IAP (1) IFNAR (2) Influenza Virus (44) Interleukin Related (1) Isotope-Labeled Compounds (19) JNK (1) Measles Virus (1) Mitochondrial Metabolism (4) Mitosis (6) Molecular Glues (5) Monoamine Oxidase (1) mTOR (3) NF-κB (1) NOD-like Receptor (NLR) (2) Nucleoside Antimetabolite/Analog (18) Oxidative Phosphorylation (3) p38 MAPK (1) Parasite (7) PDGFR (1) Phosphatase (3) PKC (1) Potassium Channel (4) PROTACs (1) Pyroptosis (2) RAD51 (1) Ras (1) Reference Standards (26) Reverse Transcriptase (5) RSV (6) SARS-CoV (38) Ser/Thr Kinase (1) Sirtuin (3) Sodium Channel (1) STING (1) Topoisomerase (7) Virus Protease (2)
By Research Areas:	Cancer (104) Cardiovascular Disease (7) Infection (191) Inflammation/Immunology (16) Metabolic Disease (10) Neurological Disease (5)
Click Chemistry:	Azide (6)
Oligonucleotides:	Adenosine (2) Guanine Nucleotide (1) Nucleotide Analogs (7) Nucleoside Analogs (9) Uridine (2) Cytidine Nucleotide (1) Cytidine (4)

309

Inhibitors & Agonists

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Targets Recommended: MicroRNA mRNA RNA MTase Small Interfering RNA (siRNA) PARP DNA/RNA Synthesis Aminoacyl-tRNA Synthetase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14768

Favipiravir 50+ Cited Publications T-705	DNA/RNA Synthesis Influenza Virus SARS-CoV Bacterial	Infection
Favipiravir (T-705) is a potent viral **RNA polymerase** inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

HY-103586

GS-441524 25+ Cited Publications	DNA/RNA Synthesis SARS-CoV	Infection
GS-441524 is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 reduces viral RNA levels in cats. GS-441524 can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .

HY-N0540

Cynaroside 10+ Cited Publications Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside	Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal	Infection Cardiovascular Disease Cancer
Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent **RNA polymerase inhibitor with an IC₅₀** of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-134539

IMT1 5+ Cited Publications	Oxidative Phosphorylation Mitochondrial Metabolism DNA/RNA Synthesis	Metabolic Disease Cancer
IMT1 is a first-in-class specific and noncompetitive human *mitochondrial RNA* polymerase (POLRMT)** inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases .

HY-D1020

7-Aminoactinomycin D 5+ Cited Publications 7-AAD	DNA/RNA Synthesis Bacterial DNA Stain Antibiotic	Infection Cancer
7-Aminoactinomycin D (7-AAD) a cell-impermeant fluorescent DNA stain, is a potent **RNA polymerase** inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .

HY-10241

Simeprevir 40+ Cited Publications TMC435; TMC435350	HCV HCV Protease SARS-CoV DNA/RNA Synthesis	Infection
Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M ^pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

HY-17580

Fidaxomicin 5+ Cited Publications OPT-80; PAR-101	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic	Infection
Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent **RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial** activity and a good anti-Clostridium difficile activity (MIC₉₀=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .

HY-12484

BMH-21 10+ Cited Publications	DNA/RNA Synthesis	Cancer
BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity .

HY-137067

IMT1B 5+ Cited Publications LDC203974	DNA/RNA Synthesis	Cancer
IMT1B (LDC203974) is an orally active, noncompetitive and specific allosteric inhibitor of *mitochondrial RNA* polymerase (POLRMT)** and inhibits mitochondrial DNA (mtDNA) expression. IMT1B has anti-tumour effects .

HY-13998

Dasabuvir 10+ Cited Publications ABT-333	HCV DNA/RNA Synthesis	Infection
Dasabuvir (ABT-333) is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir inhibits RNA-dependent **RNA polymerase encoded by the HCV NS5B gene. Dasabuvir inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC₅₀** values of 7.7 and 1.8 nM, respectively .

HY-145586

Onradivir ZSP1273	Influenza Virus DNA/RNA Synthesis	Infection
Onradivir (ZSP1273) is an orally active antiviral agent targeting *influenza A virus RNA* polymerase PB2 subunit with an IC₅₀** of 0.562 nM. Onradivir inhibits cap binding to influenza A virus RNA polymerase PB2 subunit, suppresses viral replication, reduces viral titres and RNA loads, and inhibits influenza A virus infection. Onradivir maintains high survival rates in influenza A virus-infected mice, and reduces influenza A virus titers in a murine model. Onradivir can be used for the research of influenza A virus infection .

HY-131081

γ-Amanitin	DNA/RNA Synthesis ADC Payloads	Cancer
γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC₅₀ of 163.1 ng/mL. γ-Amanitin is toxic to a variety of cells .

HY-16662

Oncrasin-1	DNA/RNA Synthesis Ras Apoptosis	Cancer
Oncrasin-1 is an **RNA polymerase** inhibitor. Oncrasin-1 suppresses the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells. Oncrasin-1 effectively kills various human lung cancer cells with K-Ras mutations. Oncrasin-1 leads to coaggregation of PKCι and splicing factors into megaspliceosomes. Oncrasin-1 induces malfunction in the RNA processing machinery. Oncrasin-1 is an anti-cancer agent and can therefore be studied in research for lung cancer .

HY-W001951

Dirhodium tetraacetate Tetrakis(acetato)dirhodium(II); Rhodium(II) acetate dimer	DNA/RNA Synthesis	Cancer
Dirhodium tetraacetate (Tetrakis (acetato) dirhodium (II)) is an anticancer agent. Dirhodium tetraacetate functionally inhibits the activities of DNA polymerase I and RNA polymerase. It also acts as a catalyst and can be used to construct rhodium-based artificial metalloenzymes .

HY-175238

KI-DX-014	ATP Synthase DNA/RNA Synthesis	Neurological Disease Cancer
KI-DX-014 is a DDX21 inhibitor with high RNA-binding inhibitory activity (IC₅₀ of 3.31 μM). KI-DX-014 targets DDX21’s intrinsically disordered C-terminal domain, inhibits DDX21-structured RNA interaction, modulates DDX21’s RNA-dependent ATPase activity, and disrupts DDX21 biomolecular condensate formation. KI-DX-014 attenuates in vitro P-TEFb release from the 7SK snRNP complex, suppresses P-TEFb-dependent RNA polymerase II CTD phosphorylation, and induces developmental defects in zebrafish embryos. KI-DX-014 acts as a chemical probe for dissecting DDX21 functions in normal physiology and disease states. KI-DX-014 can be used for cancers and neurodegenerative disorders research .

HY-N3519

Platycodin D3 1 Publications Verification	HCV Branched Chain Amino Acid Transaminase (BCAT) Interleukin Related NF-κB ERK p38 MAPK JNK	Infection Inflammation/Immunology
Platycodin D3 is a triterpenoid saponin that can be found in Platycodon grandiflorum. Platycodin D3 exhibits multiple activities including anti-inflammation, regulation of airway mucus secretion, improvement of asthmatic airway inflammation and remodeling, and inhibition of hepatitis C virus (HCV) replication. The IC₅₀ value of Platycodin D3 against HCV NS5B RNA-dependent RNA polymerase is 8 μg/mL. Platycodin D3 can be used in studies related to asthma, hepatitis C virus infection and inflammatory diseases .

HY-16200

Ethynylcytidine 2 Publications Verification ECyD; TAS-106; 3'-C-Ethynylcytidine	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Cancer
Ethynylcytidine (ECyD), a nucleoside analog and a potent inhibitor of RNA synthesis, inhibits RNA polymerases I, II and II. Ethynylcytidine has robust antitumor activity in a wide range of models of cancer . Ethynylcytidine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-112626

CDK12-IN-2 1 Publications Verification	CDK	Cancer
CDK12-IN-2 is a potent, selective and nanomolar CDK12 inhibitor (IC₅₀=52 nM) with good physicochemical properties. CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12 .

HY-17026A

Gemcitabine triphosphate dFdCTP	Drug Metabolite DNA/RNA Synthesis Apoptosis	Cancer
Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate shows a K_i of 11.2 μM against *DNA polymerase* α and 14.4 μM against DNA polymerase ε*. Gemcitabine triphosphate partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate disrupts DNA and RNA* synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate can be used for the research of pancreatic cancer and non-small cell lung cancer .

HY-113225

Guanosine triphosphate GTP	Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis	Cancer
Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-112062

POL1-IN-1	DNA/RNA Synthesis Apoptosis	Cancer
POL1-IN-1 is a class of RNA polymerase I inhibitors with broad-spectrum antiproliferative activity against tumor cells, while selectively inhibiting RNA polymerase I transcription. By blocking RNA polymerase I-mediated rRNA synthesis, POL1-IN-1 impairs ribosome biogenesis, thereby inhibiting tumor cell proliferation and inducing apoptosis. POL1-IN-1 can be used for the research of malignant tumors .

HY-75800

Lomibuvir 2 Publications Verification VX-222	DNA/RNA Synthesis HCV	Infection
Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the *HCV NS5B polymerase* (RdRp) with a K_d of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC₅₀** of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis .

HY-122587

AVG-233	DNA/RNA Synthesis RSV	Infection
AVG-233 is a potent, orally active RNA dependent RNA polymerase (RdRp) inhibitor. AVG-233 prevents initiation of the viral polymerase complex at the promoter. AVG-233 binding site is present in the L_1-1749 fragment. AVG-233 has nanomolar activity against both RSV strains and clinical RSV isolates (EC₅₀=0.14-0.31 μM). AVG-233 can be used for research of respiratory syncytial virus (RSV) .

HY-145072

BSJ-01-175	CDK	Cancer
BSJ-01-175 is a potent and selective CDK12/13 covalent inhibitor. BSJ-01-175 demonstrates exquisite selectivity, potent inhibition of RNA polymerase II phosphorylation, and downregulation of CDK12-targeted genes in cancer cells .

HY-E70090

T7 RNA polymerase	DNA/RNA Synthesis	Infection
T7 RNA polymerase is a polymerase expressed by Escherichia coli from the RNA polymerase gene of T7 bacteriophage. T7 RNA polymerase is highly specific and involved in in vitro transcription (IVT) of mRNA. In the presence of Mg ²⁺, T7 RNA polymerase only uses the single-stranded or double-stranded DNA containing the T7 promoter sequence as a template, and uses NTP as a substrate to synthesize RNA complementary to the single-stranded DNA downstream of the promoter .

HY-D1686

Biotin-16-UTP Biotin-16-UTP tetralithium	DNA Stain	Others
Biotin-16-UTP is an active substrate for RNA polymerase. Biotin-16-UTP can replace UTP in the in vitro transcription reaction for RNA labeling .

HY-147917

RNA polymerase II-IN-2	ADC Payloads DNA/RNA Synthesis	Cancer
RNA polymerase II-IN-2 is a RNA polymerase II inhibitor with a K_i value of 74.1 nM. RNA polymerase II-IN-2 inhibits Pol II-mediated transcription and induces cytotoxicity in mammalian cells. RNA polymerase II-IN-2 serves as a payload for antibody-drug conjugates (ADC) and is applicable for cancer research .

HY-128917

DNA31	DNA/RNA Synthesis	Infection
DNA31 is a potent **RNA polymerase** inhibitor .

HY-148478

MMV688845 (R)-GSK1729177A	DNA/RNA Synthesis	Infection
MMV688845 is a nontuberculous mycobacteria (NTM) RNA polymerase inhibitor with bactericidal activity against Mycobacterium abscessus and anti-tuberculosis efficacy .

HY-13247

Setrobuvir ANA598	DNA/RNA Synthesis HCV SARS-CoV	Infection
Setrobuvir (ANA598) is an orally active non-nucleosidic HCV NS5B polymerase inhibitor. ANA-598 inhibits both de novo RNA synthesis and primer extension, with IC₅₀s between 4 and 5 nM. Setrobuvir also shows excellent binding affinity to SARS-CoV-2 RdRp and induces RdRp inhibition .

HY-172918

VV261	Influenza Virus Arenavirus	Infection
VV261 is an orally active prodrug of 4'-fluorouridine. VV261 inhibits viral RNA-dependent RNA polymerase. VV261 exhibits antiviral activity against CCHFV, SFTSV and LCMV. VV261 can be used in research related to viral infections .

HY-118723

BMH-22	DNA/RNA Synthesis	Cancer
BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types .

HY-138646

Poly(deoxyadenylic-thymidylic) acid sodium 4 Publications Verification Poly(dA:dT) sodium	Cyclic GMP-AMP Synthase STING	Inflammation/Immunology
Poly(deoxyadenylic-thymidylic) acid (Poly(dA:dT)) sodium is a double-stranded DNA stimulant. Poly(deoxyadenylic-thymidylic) acid sodium is recognized by the intracellular DNA sensor DDX41 and activates the innate immune pathway via the adaptor protein STING, inducing the production of cytokines such as type I interferons. Poly(deoxyadenylic-thymidylic) acid sodium also serves as an in vitro transcription template for free RNA polymerase .

HY-103586A

GS-441524 hydrochloride 25+ Cited Publications	DNA/RNA Synthesis SARS-CoV	Infection
GS-441524 hydrochloride is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 hydrochloride competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 hydrochloride inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 hydrochloride reduces viral RNA levels in cats. GS-441524 hydrochloride can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .

HY-D1686B

Biotin-16-UTP tetrasodium	DNA Stain	Others
Biotin-16-UTP tetrasodium is an active substrate for RNA polymerase. Biotin-16-UTP tetrasodium can replace UTP in the in vitro transcription reaction for RNA labeling .

HY-139442

RdRP-IN-2	DNA/RNA Synthesis SARS-CoV	Infection
RdRP-IN-2 is a RNA dependent RNA polymerase (RdRp) inhibitor. RdRP-IN-2 significantly inhibits SARS-CoV-2 RdRp with an IC₅₀ of 41.2 μM.RdRP-IN-2 also inhibits Feline coronavirus (FIPV) replication .

HY-19643

JTK-109	HCV Protease	Infection
JTK-109 is a potent inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase. JTK-109 has NS5B inhibitory activity with IC₅₀ value of 0.017μM. JTK-109 can be used for the research of hepatitis C virus (HCV) .

HY-N0540R

Cynaroside (Standard) 10+ Cited Publications Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)	Apoptosis DNA/RNA Synthesis Parasite Bacterial Influenza Virus Fungal Reference Standards	Infection Cancer
Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent **RNA polymerase inhibitor with an IC₅₀** of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-163015

RNA polymerase-IN-1	DNA/RNA Synthesis	Infection
RNA polymerase-IN-1 (compound 4) is s DNA-dependent **RNA polymerase** inhibitor. RNA polymerase-IN-1 inhibits CYP isozymes .

HY-109047

Adafosbuvir AL-335	HCV DNA/RNA Synthesis	Infection
Adafosbuvir (AL-335), a precursor compound of a uridine-based nucleotide analog polymerase (NS5B) inhibitor, has potent antiviral activity against HCV and acts as a potent inhibitor of HCV RNA polymerase .

HY-148167

2'-Deoxy-2'-fluoro-l-uridine	DNA/RNA Synthesis Virus Protease	Infection
2'-Deoxy-2'-fluoro-l-uridine is an L-nucleoside compound. 2'-Deoxy-2'-fluoro-l-uridine is a potent, selective viral **RNA polymerase** inhibitor, thereby inhibiting RNA virus replication .

HY-135780

3'-Deoxyuridine-5'-triphosphate 3'-dUTP	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite	Metabolic Disease
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into *RNA* with a K_i value of 2.0 μM .

HY-177743

TR-213	Molecular Glues CDK DNA/RNA Synthesis	Cancer
TR-213 is a potent molecular glue degrader that targets Cyclin K (CDK). TR-213 induces 91% and 56% decrease in CDK12 and Cyclin at 1 μM. TR-213 can inhibit RNA polymerase II activity and regulates alternative polyadenylation (APA) activity. TR-213 can be used for the research of cancer .

HY-163016

RNA polymerase-IN-2	DNA/RNA Synthesis	Infection
RNA polymerase-IN-2 (compound 5) is s DNA-dependent **RNA polymerase** inhibitor. RNA polymerase-IN-2 inhibits CYP isozymes .

HY-153696

MRL-436	DNA/RNA Synthesis Bacterial	Infection
MRL-436 is a **RNA polymerase** inhibitor with antibacterial activity. MRL-436 exerts its antibacterial activity dependent on residue 622 of the RNA polymerase β' subunit and the RNAP ω subunit. MRL-436 inhibits Rifampicin (HY-B0272)-resistant RNA polymerase derivatives and exhibits antibacterial activity against Rifampicin-resistant strains .

HY-179029

RNA polymerase-IN-4	DNA/RNA Synthesis Influenza Virus	Infection
RNA polymerase-IN-4 is a **RNA polymerase inhibitor with an EC₅₀** of 22.81 nM. RNA polymerase-IN-4 exhibits potent anti-influenza virus activity (EC₅₀ = 3.76 nM), relatively low cytotoxicity (CC₅₀ = 29.91 μM). RNA polymerase-IN-4 can be used for the research of infection, such as influenza virus infection .

HY-13998A

Dasabuvir sodium ABT-333 sodium	HCV DNA/RNA Synthesis	Infection
Dasabuvir (ABT-333) sodium is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir sodium inhibits RNA-dependent **RNA polymerase encoded by the HCV NS5B gene. Dasabuvir sodium inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC₅₀** values of 7.7 and 1.8 nM, respectively .

HY-W050151

2,5-Di-tert-butyl-1,4-benzoquinone	Bacterial DNA/RNA Synthesis	Infection
2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent that defends the emerging antibacterial resistance, which is found in marine Streptomyces sp. VITVSK1. 2,5-Di-tert-butyl-1,4-benzoquinone is also a potent inhibitor of **RNA polymerase** .

HY-10241A

Simeprevir sodium TMC435 sodium; TMC435350 sodium	HCV HCV Protease SARS-CoV DNA/RNA Synthesis	Infection
Simeprevir (TMC435; TMC435350) sodium is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir sodium inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir sodium also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir sodium inhibits the main protease (M ^pro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

HY-171786

CDK12-IN-8	CDK	Cancer
CDK12-IN-8 (Compound Cpd143) is an orally active and highly selective inhibitor of cyclin-dependent kinase 12 (CDK12). CDK12-IN-8 inhibits CDK12-mediated phosphorylation of the C-terminal domain (CTD) serine 2 of RNA polymerase II, interfering with gene transcription elongation and DNA damage repair pathways. CDK12-IN-8 is promising for research of cancers with high CDK12 expression such as small cell lung cancer and triple-negative breast cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0112

Dihydromyricetin Maximum Cited Publications 24 Publications Verification Ampelopsin; Ampeloptin	Infection Flavanonols Structural Classification Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	mTOR Influenza Virus DNA/RNA Synthesis Autophagy
Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

HY-N0540

Cynaroside 10+ Cited Publications Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside	Infection Structural Classification Flavonoids Classification of Application Fields Flavones Centaurea ornata Phenols Polyphenols Umbelliferae Plants Disease Research Fields	Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal
Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent **RNA polymerase inhibitor with an IC₅₀** of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-17580

Fidaxomicin 5+ Cited Publications OPT-80; PAR-101	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Phenols Polyphenols Antibacterial Disease Research Disease Research Fields Source Classification	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic
Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent **RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial** activity and a good anti-Clostridium difficile activity (MIC₉₀=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .

HY-100126

Tubercidin 5+ Cited Publications 7-Deazaadenosine	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic
Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC₅₀ of 0.02 μM . Tubercidin inhibits polymerases by incorporating DNA or *RNA, thereby inhibiting DNA replication, RNA* and protein synthesis . Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP . Tubercidin has antiviral activity .

HY-N2183

Baimaside 3 Publications Verification Quercetin 3-O-sophoroside	Apocynaceae Flavonols Structural Classification Flavonoids Classification of Application Fields Other Diseases Phenols Polyphenols Plants Apocynum venetum Linn. Disease Research Fields Source Classification	SARS-CoV
Baimaside (Quercetin 3-O-sophoroside) is a flavonoid cholinergic function modulator that binds to SARS-CoV-2-related targets. Baimaside regulates the expression of cholinergic system-related proteins and acetylcholine levels, improves scopolamine-induced learning and memory impairment, protects hippocampal neurons, inhibits pollen protein fluorescence, and protects pollen DNA. Its biosynthesis is regulated by multiple enzymes. Baimaside is completely absorbed in rats, undergoes phase Ⅱ metabolism and gut microbiota decomposition, and inhibits the invasion and proliferation of SARS-CoV-2 and its variants, making it suitable for research related to Alzheimer's disease and COVID-19 .

HY-131081

γ-Amanitin	Structural Classification Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification Cancer	DNA/RNA Synthesis ADC Payloads
γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin. γ-Amanitin competitively binds to monoclonal antibody (mAb), with an IC₅₀ of 163.1 ng/mL. γ-Amanitin is toxic to a variety of cells .

HY-17026E

Gemcitabine triphosphate trisodium dFdCTP trisodium	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Drug Metabolite DNA/RNA Synthesis Apoptosis
Gemcitabine triphosphate (dFdCTP) trisodium is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate trisodium cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate trisodium shows a K_i of 11.2 μM against *DNA polymerase* α and 14.4 μM against DNA polymerase ε*. Gemcitabine triphosphate trisodium partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate trisodium disrupts DNA and RNA* synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate trisodium can be used for the research of pancreatic cancer and non-small cell lung cancer .

HY-N6712

Thiolutin 4 Publications Verification Acetopyrrothin	Structural Classification Microorganisms Classification of Application Fields Antibiotics Metabolic Disease Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic Bacterial Deubiquitinase NOD-like Receptor (NLR) DNA/RNA Synthesis Pyroptosis HMG-CoA Reductase (HMGCR)
Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC₅₀ = 4 μM) and Rpn11 (IC₅₀ = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin-induced cardiotoxicity (DOXIC) ^{[1][2][3][4][5]}.

HY-N3519

Platycodin D3 1 Publications Verification	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Source Classification	HCV Branched Chain Amino Acid Transaminase (BCAT) Interleukin Related NF-κB ERK p38 MAPK JNK
Platycodin D3 is a triterpenoid saponin that can be found in Platycodon grandiflorum. Platycodin D3 exhibits multiple activities including anti-inflammation, regulation of airway mucus secretion, improvement of asthmatic airway inflammation and remodeling, and inhibition of hepatitis C virus (HCV) replication. The IC₅₀ value of Platycodin D3 against HCV NS5B RNA-dependent RNA polymerase is 8 μg/mL. Platycodin D3 can be used in studies related to asthma, hepatitis C virus infection and inflammatory diseases .

HY-17026A

Gemcitabine triphosphate dFdCTP	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Drug Metabolite DNA/RNA Synthesis Apoptosis
Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate shows a K_i of 11.2 μM against *DNA polymerase* α and 14.4 μM against DNA polymerase ε*. Gemcitabine triphosphate partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate disrupts DNA and RNA* synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate can be used for the research of pancreatic cancer and non-small cell lung cancer .

HY-113225

Guanosine triphosphate GTP	Infection Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis
Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-125650

Pseudouridimycin 1 Publications Verification PUM	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Antibiotic DNA/RNA Synthesis Bacterial Nucleoside Antimetabolite/Analog
Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC₅₀ of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis .

HY-135780A

3'-Deoxyuridine-5'-triphosphate trisodium 3'-dUTP trisodium	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite
3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into *RNA* with a K_i value of 2.0 μM .

HY-N0540R

Cynaroside (Standard) 10+ Cited Publications Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)	Structural Classification Flavonoids Flavones Centaurea ornata Phenols Polyphenols Umbelliferae Plants	Apoptosis DNA/RNA Synthesis Parasite Bacterial Influenza Virus Fungal Reference Standards
Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent **RNA polymerase inhibitor with an IC₅₀** of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-W004924

5-Hydroxymethyluracil	Natural Products Other disease Classification of Application Fields Disease markers Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.

HY-135867

NHC-triphosphate	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase SARS-CoV
NHC-triphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .

HY-135780

3'-Deoxyuridine-5'-triphosphate 3'-dUTP	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into *RNA* with a K_i value of 2.0 μM .

HY-135867A

NHC-triphosphate tetrasodium	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase
NHC-triphosphate tetrasodium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form . NHC-triphosphate tetrasodium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .

HY-N12982

α-Calacorene	Structural Classification Terpenoids Gramineae Sesquiterpenes Plants Chrysopogon zizanioides (L.) Roberty Source Classification	Others
α-Calacorene is a sesquiterpene that can be isolated from Réunion vetiver oil .

HY-17580R

Fidaxomicin (Standard) OPT-80 (Standard); PAR-101 (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Antibacterial Disease Research Source Classification	Reference Standards DNA/RNA Synthesis Bacterial Apoptosis Antibiotic
Fidaxomicin (Standard) is the analytical standard of Fidaxomicin. This product is intended for research and analytical applications. Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent **RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial** activity and a good anti-Clostridium difficile activity (MIC₉₀=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .

HY-126406

Tirandamycin A	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Anti-parasitic Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial DNA/RNA Synthesis Parasite Antibiotic
Tirandamycin A, an antibiotic, is a bacterial RNA polymerase inhibitor. Tirandamycin A has antiamoebic and antibacterial properties .

HY-131083

ε-Amanitin	Structural Classification Natural Products Monophenols Microorganisms Classification of Application Fields Phenols Disease Research Fields Source Classification Cancer	DNA/RNA Synthesis ADC Payloads
ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II .

HY-N0112R

Dihydromyricetin (Standard) Ampelopsin (Standard); Ampeloptin (Standard)	Flavanonols Structural Classification Flavonoids other families Phenols Polyphenols Plants Source Classification	Reference Standards mTOR Influenza Virus DNA/RNA Synthesis Autophagy
Dihydromyricetin (Standard) is the analytical standard of Dihydromyricetin. This product is intended for research and analytical applications. Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

HY-N11522

5-Methyluridine 5′-triphosphate 5-Methyl-UTP	Structural Classification Animals Ketones, Aldehydes, Acids Source Classification	Nucleoside Antimetabolite/Analog
5-Methyluridine 5′-triphosphate (5-Methyl-UTP) is a UTP (HY-107372) analog. 5-Methyluridine 5′-triphosphate stimulates incorporation of [ ³H]-GMP by RNA polymerase I much better than UTP .

HY-135867F

NHC-diphosphate triammonium 1 Publications Verification	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	CHIKV Endogenous Metabolite Enterovirus HCV Topoisomerase SARS-CoV
NHC-diphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a diphosphate form . NHC-diphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA .

HY-N13915

Scorodonin	Structural Classification Natural Products Microorganisms Source Classification	Bacterial Fungal DNA/RNA Synthesis
Scorodonin has anti-bacterial, Streptomyces and fungal effects. Scorodonin inhibits DNA-dependent RNA polymerases with an IC₅₀ of 25 μg/mL .

HY-N7821

Aphidicolin 17-acetate Aphidicolin 17-monoacetate	Structural Classification Natural Products Microorganisms Source Classification	DNA/RNA Synthesis
Aphidicolin 17-acetate is a selective eukaryotic *DNA polymerase* α** inhibitor. Aphidicolin 17-acetate does not inhibit DNA polymerase β and γ. Aphidicolin 17-acetate markedly inhibits the in vivo DNA synthesis of sea urchin embryos and HeLa cells but not RNA and protein syntheses .

HY-W004924R

5-Hydroxymethyluracil (Standard)	Structural Classification Natural Products Other disease Disease markers Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.

HY-N14351

Ferrocin A	Natural Products Microorganisms Source Classification	SARS-CoV Bacterial Antibiotic
Ferrocin A is a lipopeptide compound that targets the SARS-CoV-2 RNA-dependent RNA polymerase (nsp12). Ferrocin A can stably bind to nsp12, and as an iron-chelating peptide, it reduces the concentration of free iron in the environment via complexation, thereby inhibiting bacterial growth by repressing the acquisition of essential metal cations. As an iron-chelating antiviral molecule, Ferrocin A may be used in studies related to COVID-19 and bacterial infections .

HY-100126R

Tubercidin (Standard) 7-Deazaadenosine (Standard)	Structural Classification Microorganisms Antibiotics Antiviral Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic
Tubercidin (Standard) is the analytical standard of Tubercidin. This product is intended for research and analytical applications. Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM[1]. Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis[2]. Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP[1]. Tubercidin has antiviral activity[2].

HY-N6712R

Thiolutin (Standard) Acetopyrrothin (Standard)	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Antibiotic Bacterial Deubiquitinase NOD-like Receptor (NLR) DNA/RNA Synthesis Pyroptosis HMG-CoA Reductase (HMGCR)
Thromycin (Standard) is the analytical standard of thromycin (Acetopyrrothin) (HY-N6712). Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC₅₀ = 4 μM) and Rpn11 (IC₅₀ = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin (HY-15142A)-induced cardiotoxicity (DOXIC) ^{[1][2][3][4][5]}.

HY-N14957

Clavicoronic acid	Natural Products Microorganisms Source Classification	Antibiotic
Clavicoronic acid is an avian myeloblastosis virus and Moloney murine leukemia virus reverse transcriptases inhibitor with K_i values of 130, 68 µM, respectively. Clavicoronic acid inhibits the multiplication of vesicular stomatitis virus by interfering with this virus's RNA-directed RNA-polymerase. Clavicoronic acid shows no cytotoxicity .

HY-182552

Soulattrolide	Structural Classification Calophyllum teysmannii Miq. Coumarins Phenylpropanoids Plants Calophyllaceae Source Classification	HIV Reverse Transcriptase DNA/RNA Synthesis
Soulattrolide is a non-nucleoside HIV-1 reverse transcriptase (RT) inhibitor with IC₅₀ values of 0.34 µM for HIV-1 RT, 69.5 µM for E. coli RNase H, and >495 µM for human *DNA polymerase* β*, and can be found in Calophyllum teysmannii* latex. Soulattrolide can be used for the research of HIV-1 infection, pain, inflammation, and Mycobacterium tuberculosis infection .

Cat. No.	Product Name	Chemical Structure

HY-17025S

Rifabutin-d7
Rifabutin-d₇ is the deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.

HY-17580S

Fidaxomicin-d7
Fidaxomicin-d₇ (OPT-80-D₇) is the deuterium labeled Fidaxomicin. Fidaxomicin (OPT-80), a macrocyclic RNA polymerase inhibitor, has a narrow spectrum of activity. Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora .

HY-113225S2

Guanosine triphosphate-13C dilithium

Guanosine triphosphate- ¹³C (GTP- ¹³C) dilithium is ¹³C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S5

Guanosine triphosphate-13C10 dilithium

Guanosine triphosphate- ¹³C₁₀ (GTP- ¹³C₁₀) dilithium is ¹³C-labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S3

Guanosine triphosphate-15N5 dilithium

Guanosine triphosphate- ¹⁵N₅ (GTP- ¹⁵N₅) dilithium is ¹⁵N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-W011834S

2'-O-Methylcytidine-d3
2'-O-Methylcytidine-d₃ is deuterium labeled 2'-O-Methylcytidine (HY-W011834). 2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.

HY-128974S

N-Dodecyl-β-D-maltoside-d25

N-Dodecyl-β-D-maltoside-d₂₅ (Lauryl Maltoside-d₂₅) is deuterium labeled N-Dodecyl-β-D-maltoside (HY-128974). N-Dodecyl-β-D-maltoside is a non-ionic detergent. N-Dodecyl-β-D-maltoside has strong adsorption on alumina, titanium dioxide and hematite. N-Dodecyl-β-D-maltoside can promote the reactivation of various proteins. N-Dodecyl-β-D-maltoside can effectively stabilize photoactive reaction center complexes (RCs) and inhibit the degradation of Rhodopseudomonas spheroides R-26 reaction center in solution. N-Dodecyl-β-D-maltoside can be used for purification and stabilization of RNA polymerase and for detection of protein-lipid interactions .

HY-109025AS

Baloxavir-d5
Baloxavir-d₅ is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-10241S

Simeprevir-13C,d3

Simeprevir- ¹³C,d₃ is the ¹³C- and deuterium labeled Simeprevir. Simeprevir is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K_i of 0.36 nM. Simeprevir inhibits HCV replication with an EC₅₀ of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses .

HY-14768S

Favipiravir-13C15N

Favipiravir- ¹³C ¹⁵N (T-705- ¹³C ¹⁵N) is ¹³C and ¹⁵N labeled Favipiravir. Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

HY-W004924S

5-Hydroxymethyluracil-d3
5-Hydroxymethyluracil-d₃ is the deuterium labeled 5-Hydroxymethyluracil . 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase .

HY-W751835

Baloxavir-d4

Baloxavir-d₄ (Baloxavir acid-d₄; S-033447-d₄) is the deuterium-labeled Baloxavir (HY-109025A). Baloxavir-d₄ (Baloxavir-d₄ acid), derived from the proagent Baloxavir-d₄ marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir-d₄ inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-113225S1

Guanosine triphosphate-13C10,15N5 tetraammonium solution (100 mM)

Guanosine triphosphate- ¹³C₁₀, ¹⁵N₅ tetraammonium is the ¹³C and ¹⁵N labeled Guanosine triphosphate tetraammonium. Guanosine triphosphate tetraammonium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate tetraammonium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate tetraammonium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate tetraammonium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate tetraammonium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-113225S4

Guanosine triphosphate-15N5,d14 dilithium

Guanosine triphosphate- ¹⁵N₅,d₁₄ (GTP- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled Guanosine triphosphate (HY-113225). Guanosine triphosphate dilithium (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate dilithium promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate dilithium links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate dilithium accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate dilithium is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .

HY-W769714

Favipiravir-13C3
Favipiravir- ¹³C3 is the ¹³C labeled isotope of Favipiravir (HY-14768). Favipiravir (T-705) is a potent viral **RNA polymerase** inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

HY-17025S1

Rifabutin-d6
Rifabutin-d₆ (Ansamycin-d₆) is deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.

HY-N0112S

Dihydromyricetin-d4

Dihydromyricetin-d₄ (Ampelopsin-d₄) is deuterium labeled Dihydromyricetin. Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

HY-B0843AS

Metalaxyl-M-d6

Metalaxyl-M-d₆ ((R)-Metalaxyl-d₆) is the deuterium labeled Metalaxyl-M (HY-B0843A). Metalaxyl-M ((R)-Metalaxyl) is an orally active and selective inhibitor of fungal RNA polymerase, which exerts fungicidal activity by selectively interfering with the synthesis of fungal ribosomal RNA. Metalaxyl-M can also be used to induce inflammation in hepatocytes and regulate tryptophan metabolism. Metalaxyl-M can be used in ecotoxicology studies .

HY-W013403S

2'-Deoxy-2'-fluorouridine-d2

2'-Deoxy-2'-fluorouridine-d₂ is the deuterium labeled 2'-Deoxy-2'-fluorouridine . 2'-Deoxy-2'-fluorouridine is a derivative of the pyrimidine nucleoside uridine. 2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. Hepatitis C polyU/UC RNA strands containing 2'-Deoxy-2'-fluorouridine, bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2'-Deoxy-2'-fluorouridine also has been used as a starting material in the synthesis of respiratory syncytial virus (RSV) polymerase inhibitors. 2'-Deoxy-2'-fluorouridine can incorporate into DNA and RNA in rat and woodchuck model upon administration. 2'-Deoxy-2'-fluorouridine can be studied in anti-viral research .

HY-103586S2

GS-441524-d

GS-441524-d is the deuterium labeled GS-441524 (HY-103586). GS-441524 is a potent, orally active and CNS-penetrant viral RNA-dependent RNA polymerase inhibitor. GS-441524 competes with natural nucleosides to block viral RNA transcription as an alternative substrate and RNA chain terminator. GS-441524 inhibits the replication of feline infectious peritonitis virus, African swine fever virus, and severe acute respiratory syndrome coronavirus 2. GS-441524 reduces viral RNA levels in cats. GS-441524 can be used in research related to feline infectious peritonitis, African swine fever, and coronavirus disease 2019 (COVID-19) .

HY-109025AS2

Baloxavir-d1
Baloxavir-d₁ is the deuterium labeled Baloxavir (HY-109025A). Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .

HY-17580S1

Fidaxomicin-d6

Fidaxomicin-d₆ (OPT-80-d₆) is the deuterium labeled Fidaxomicin (HY-17580). Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC₉₀=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research .

Targets Recommended: MicroRNA mRNA RNA MTase Small Interfering RNA (siRNA) PARP DNA/RNA Synthesis Aminoacyl-tRNA Synthetase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13689G

Go 6983	PKC Histone Methyltransferase DNA Methyltransferase DNA/RNA Synthesis	Inflammation/Immunology
Go 6983 GMP is Go 6983 (HY-13689) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Go 6983 is a dual inhibitor targeting Suv39h1/2 (KMT1A/KMT1B) and PKC, as well as a transcriptional activator capable of inducing DNA hypomethylation. Go 6983 stimulates the transcription of Prdm14 by reducing Suv39h1/2 protein levels, decreasing histone modifications in the Prdm14 promoter region, and increasing the recruitment of RNA polymerase II. Go 6983 induces genome-wide DNA hypomethylation by inhibiting de novo methyltransferase expression and increasing Tet1/Tet2 levels, thereby promoting self-renewal and pluripotency maintenance of stem cells. Meanwhile, Go 6983 can block PKC-mediated signaling pathways to reduce the expression of EMT-related genes and eliminate the upregulation of antioxidant genes downstream of NRF2. Go 6983 is mainly used in mechanism studies related to myocardial ischemia/reperfusion injury .

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