Receptor-interacting Protein 1

By Targets:	RIP kinase (9) Apoptosis (2) Caspase (2) Glutathione Peroxidase (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2)
By Research Areas:	Cancer (4) Inflammation/Immunology (8)

Targets Recommended: RIP kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16658B

Z-VAD-FMK Maximum Cited Publications 740 Publications Verification Z-VAD(OH)-FMK	Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

HY-101032

RIPA-56 5+ Cited Publications	RIP kinase	Inflammation/Immunology
RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC₅₀ of 13 nM. RIPA-56 can be used for the treatment of systemic inflammatory response syndrome .

HY-100131

GSK481 1 Publications Verification	RIP kinase	Inflammation/Immunology
GSK481 is a highly potent, selective, and specific receptor interacting protein 1 (RIP1) kinase inhibitor with an IC₅₀ of 1.3 nM, which inhibits Ser ¹⁶⁶ phosphorylation in wild-type human RIP1 (IC₅₀=2.8 nM). GSK481 also exhibits excellent translation in the U937 cellular assay with an IC₅₀ of 10 nM .

HY-128585

GNE684	RIP kinase	Inflammation/Immunology Cancer
GNE684 is a potent inhibitor of *potent receptor interacting* protein 1 (RIP1), with mean K_i ^app** values of 21 nM, 189 nM and 691 nM for human mouse and rat RIP1, respectively .

HY-18901

RIPK1-IN-4	RIP kinase	Inflammation/Immunology
RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC₅₀s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase .

HY-153437

PB830	RIP kinase	Cancer
PB830 (compound 41) is a potent receptor interacting protein 1 kinase (RIP1) Inhibitor with an IC₅₀ of <100 nM for human RIP1. PB830 has an EC₅₀ of 1-100 nM in the cell necrosis assay .

HY-16658BG

Z-VAD-FMK	Caspase Apoptosis	Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

HY-18900

Nec-4	RIP kinase	Inflammation/Immunology
Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC₅₀ of 2.6 μM, K_i of 0.46 μM.

HY-101032R

RIPA-56 (Standard)	RIP kinase Reference Standards	Inflammation/Immunology
RIPA-56 (Standard) is the analytical standard of RIPA-56 (HY-101032). This product is intended for research and analytical applications. RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM. RIPA-56 can be used for the treatment of systemic inflammatory response syndrome .

HY-100131R

GSK481 (Standard)	RIP kinase Reference Standards	Inflammation/Immunology
GSK481 (Standard) is the analytical standard of GSK481 (HY-100131). This product is intended for research and analytical applications. GSK481 is a highly potent, selective, and specific receptor interacting protein 1 (RIP1) kinase inhibitor with an IC50 of 1.3 nM, which inhibits Ser166 phosphorylation in wild-type human RIP1 (IC50=2.8 nM). GSK481 also exhibits excellent translation in the U937 cellular assay with an IC50 of 10 nM .

Cat. No.	Product Name	Type

HY-16658BG

Z-VAD-FMK	Fluorescent Dye
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

Z-VAD-FMK

Fluorescent Dye

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

Cat. No.	Product Name	Type

HY-16658BG

Z-VAD-FMK	Biochemical Assay Reagents
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

Z-VAD-FMK

Biochemical Assay Reagents

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

Species:	Human (4) Mouse (1)
Tag:	SUMO (1) His (4) Tag Free (1) Myc (1) GST (1)
Source:	Sf9 insect cells (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701768

	RIPK1 Protein, Human (sf9, His, GST) RIPK1; Receptor-interacting serine/threonine-Protein kinase 1; Cell death Protein RIP; Receptor-interacting Protein 1; RIP-1	Human	Sf9 insect cells
	RIPK1 protein is a serine-threonine kinase that centrally regulates TNF-mediated apoptosis, necroptosis, and inflammatory pathways. Functionally, it plays a kinase-dependent role in the regulation of cell death and a kinase-independent scaffolding function in the control of inflammatory signaling and cell survival. RIPK1 Protein, Human (sf9, His, GST) is the recombinant human-derived RIPK1 protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.

HY-P704200

	RIPK1 Protein, Mouse (C-His) Ripk1; Rinp; Rip; Receptor-interacting serine/threonine-Protein kinase 1; EC 2.7.11.1; Cell death Protein RIP; Receptor-interacting Protein 1; RIP-1	Mouse	E. coli
	RIPK1 Protein, Mouse (C-His) is the recombinant mouse-derived RIPK1 protein, expressed by E. coli, with C-6*His tag.

HY-P701378

	KIF11 Protein, Human KIF11; Kinesin-like Protein KIF11; Kinesin-like Protein 1; Kinesin-like spindle Protein HKSP; Kinesin-related motor Protein Eg5; Thyroid Receptor-interacting Protein 5; TR-interacting Protein 5; TRIP-5	Human	E. coli
	KIF11 Protein, a pivotal motor protein, orchestrates mitotic spindle formation and aids in Golgi-to-surface protein transport. Beyond mitosis, it engages in complex interactions, binding to thyroid hormone receptor, participating in chromatin remodeling, and interacting with NEK6, RARRES1, and AGBL2. This multifaceted role highlights KIF11's diverse contributions to cellular processes. KIF11 Protein, Human is the recombinant human-derived KIF11 protein, expressed by E. coli , with tag free.

HY-P701379

	KIF11 Protein, Human (His) KIF11; Kinesin-like Protein KIF11; Kinesin-like Protein 1; Kinesin-like spindle Protein HKSP; Kinesin-related motor Protein Eg5; Thyroid Receptor-interacting Protein 5; TR-interacting Protein 5; TRIP-5	Human	E. coli
	KIF11 Protein, a pivotal motor protein, orchestrates mitotic spindle formation and aids in Golgi-to-surface protein transport. Beyond mitosis, it engages in complex interactions, binding to thyroid hormone receptor, participating in chromatin remodeling, and interacting with NEK6, RARRES1, and AGBL2. This multifaceted role highlights KIF11's diverse contributions to cellular processes. KIF11 Protein, Human (His) is the recombinant human-derived KIF11 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71548

	JMJD1C Protein, Human (His-SUMO-Myc) Jmjd1c; Jumonji domain containing 1C ; Jumonji domain-containing Protein 1C; Probable JmjC domain-containing histone demethylation Protein 2C; Thryoid Receptor interacting Protein; Thyroid Receptor-interacting Protein 8; TR-interacting Protein 8; TRIP-8; TRIP8	Human	E. coli
	The JMJD1C protein is a possible histone demethylase that centrally affects the histone code by targeting “Lys-9” of histone H3. Its enzymatic activity produces formaldehyde and succinic acid. JMJD1C Protein, Human (His-SUMO-Myc) is the recombinant human-derived JMJD1C protein, expressed by E. coli , with C-Myc, N-SUMO, N-10*His labeled tag.

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Host:	Mouse (3) Rabbit (1)
Reactivity:	Human (3) Mouse (1)
Application:	IHC-P (1) ICC/IF (4) IP (4) IHC-F (1) WB (4)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81539

	Phospho-RIP(S166) Antibody (YA1284) 2 Publications Verification Cell death Protein RIP,Receptor-interacting Protein 1	WB, IHC-P, IHC-F, ICC/IF, IP	Mouse
	Phospho-RIP(S166) Antibody (YA1284) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RIP(S166).

HY-P85489

	Eg5 Antibody (YA5181) EG5; HKSP; KIF11; KIF11_HUMAN; kinesin family member 11; Kinesin like Protein 1; Kinesin like spindle Protein HKSP; Kinesin-like Protein 1; Kinesin-like Protein KIF11; Kinesin-like spindle Protein HKSP; Kinesin-related motor Protein Eg5; KNSL1; MCLMR; Thyroid Receptor interacting Protein 5; Thyroid Receptor-interacting Protein 5; TR-interacting Protein 5; TRIP-5; TRIP5.	WB, IP, ICC/IF	Human
	Eg5 Antibody (YA5181) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Eg5.

HY-P80647

	Eg5 Antibody (YA776) KIF11; EG5; KNSL1; TRIP5; Kinesin-like Protein KIF11; Kinesin-like Protein 1; Kinesin-like spindle Protein HKSP; Kinesin-related motor Protein Eg5; Thyroid Receptor-interacting Protein 5; TR-interacting Protein 5; TRIP-5	WB, ICC/IF, IP	Human
	Eg5 Antibody (YA776) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Eg5.

HY-P80647A

	Eg5 Antibody (YA776)(PBS only) KIF11; EG5; KNSL1; TRIP5; Kinesin-like Protein KIF11; Kinesin-like Protein 1; Kinesin-like spindle Protein HKSP; Kinesin-related motor Protein Eg5; Thyroid Receptor-interacting Protein 5; TR-interacting Protein 5; TRIP-5	WB, ICC/IF, IP	Human
	Eg5 Antibody (YA776) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Eg5.

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Targets Recommended: RIP kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16658BG

Z-VAD-FMK	Caspase Apoptosis	Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

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