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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
Receptor-interacting Protein 1
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "Receptor-interacting Protein 1" in MCE Product Catalog:
819
Research Areas:
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .
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9 Cited Publications
Target:
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RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting
protein 1 (RIP1) with an IC50 of 13 nM. RIPA-56 can be used for the treatment of systemic inflammatory response syndrome .
2
1
1 Cited Publications
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GSK481 is a highly potent, selective, and specific receptor interacting protein 1 (RIP1) kinase inhibitor with an IC50 of 1.3 nM, which inhibits Ser 166 phosphorylation in wild-type human RIP1 (IC50=2.8 nM). GSK481 also exhibits excellent translation in the U937 cellular assay with an IC50 of 10 nM .
Cat. No.: HY-128585
CAS No.: 2438637-64-8
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GNE684 is a potent inhibitor of potent receptor interacting protein 1 (RIP1), with mean Ki app values of 21 nM, 189 nM and 691 nM for human mouse and rat RIP1, respectively .
Cat. No.: HY-18901
CAS No.: 1481641-08-0
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RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase .
Cat. No.: HY-153437
CAS No.: 2428401-23-2
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PB830 (compound 41) is a potent receptor interacting protein 1 kinase (RIP1) Inhibitor with an IC50 of <100 nM for human RIP1. PB830 has an EC50 of 1-100 nM in the cell necrosis assay .
Cat. No.: HY-16658BG
CAS No.: 161401-82-7
Cat. No.: HY-18900
CAS No.: 1041644-43-2
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Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.
Cat. No.: HY-P704200
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RIPK1; Receptor-interacting Protein Kinase 1; Receptor interacting Serine/Threonine Kinase 1; Receptor-interacting Protein 1; RIP-1; Cell Death Protein RIP; RIP1; Serine/Threonine-Protein Kinase RIP; RIP; AIEFL; Receptor (TNFRSF)-interacting Serine-Threon
Cat. No.: HY-P701768
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RIPK1; Receptor-interacting Protein Kinase 1; Receptor interacting Serine/Threonine Kinase 1; Receptor-interacting Protein 1; RIP-1; Cell Death Protein RIP; RIP1; Serine/Threonine-Protein Kinase RIP; RIP; AIEFL; Receptor (TNFRSF)-interacting Serine-Threon
Species:
Source:
Cat. No.: HY-P702935
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RIPK1; Receptor-interacting Protein Kinase 1; Receptor interacting Serine/Threonine Kinase 1; Receptor-interacting Protein 1; RIP-1; Cell Death Protein RIP; RIP1; Serine/Threonine-Protein Kinase RIP; RIP; AIEFL; Receptor (TNFRSF)-interacting Serine-Threon
Species:
Source:
Cat. No.: HY-P702936
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RIPK1; Receptor-interacting Protein Kinase 1; Receptor interacting Serine/Threonine Kinase 1; Receptor-interacting Protein 1; RIP-1; Cell Death Protein RIP; RIP1; Serine/Threonine-Protein Kinase RIP; RIP; AIEFL; Receptor (TNFRSF)-interacting Serine-Threon
Species:
Source:
Cat. No.: HY-P703063
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RIPK1; Receptor-interacting Protein Kinase 1; Receptor interacting Serine/Threonine Kinase 1; Receptor-interacting Protein 1; RIP-1; Cell Death Protein RIP; RIP1; Serine/Threonine-Protein Kinase RIP; RIP; AIEFL; Receptor (TNFRSF)-interacting Serine-Threon
Species:
Source:
Cat. No.: HY-P810838
Synonyms: DRIP5; RAP1; Telomeric repeat-binding factor 2-interacting Protein 1; TERF2-interacting telomeric Protein 1; TRF2-interacting telomeric Protein 1; Dopamine Receptor-interacting Protein 5; Repressor/activator Protein 1 homolog; RAP1 homolog; hRap1
Cat. No.: HY-P703061
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RIPK1; Receptor-interacting Protein Kinase 1; Receptor interacting Serine/Threonine Kinase 1; Receptor-interacting Protein 1; RIP-1; Cell Death Protein RIP; RIP1; Serine/Threonine-Protein Kinase RIP; RIP; AIEFL; Receptor (TNFRSF)-interacting Serine-Threon
Species:
Source:
Cat. No.: HY-P7693
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: C1QTNF1; Complement C1q Tumor Necrosis Factor-Related Protein 1; C1q And TNF Related 1; C1q And Tumor Necrosis Factor Related Protein 1; CTRP1; G Protein Coupled Receptor interacting Protein; GIP; G Protein-Coupled Receptor-interacting Protein; ZSIG37; FL
Cat. No.: HY-P704234
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: LINGO1; Leucine-Rich Repeat Neuronal Protein 1; Prev. LRRN6A; FLJ14594; LERN1; Leucine-Rich Repeat Neuronal Protein 6A; Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-interacting Protein 1; UNQ201; Leucine-Rich Repeat And Immu
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
