1. Apoptosis
  2. RIP kinase

Nec-4 

Cat. No.: HY-18900
Handling Instructions

Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.

For research use only. We do not sell to patients.

Nec-4 Chemical Structure

Nec-4 Chemical Structure

CAS No. : 1041644-43-2

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.

IC50 & Target

IC50: 2.6 μM (RIP1)[1].

In Vitro

Nec-4 (compound 9) is a slightly better competitor than 7 with a lower Ki value that is similar to R-3. Nec-4 is again a slightly better competitor than Rac-3 with Ki and IC50 values comparable to 7 (Nec-4: IC50=2.6±0.1 μM, Ki=0.46±0.05 μM; 7: IC50=10.7±1.8 μM, Ki=4.5±0.9 μM). Overall, all three compounds cross-compete with each other but Nec-4 is able to more effectively displace both 20 and 26 in comparison to the parent compounds Rac-3 and 7, respectively. This suggests that Nec-4 binding likely significantly overlaps with both the Nec-1 and the Nec-3 binding sites.

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2709 mL 16.3543 mL 32.7086 mL
5 mM 0.6542 mL 3.2709 mL 6.5417 mL
10 mM 0.3271 mL 1.6354 mL 3.2709 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

305.73

Formula

C₁₅H₁₃ClFN₃O

CAS No.

1041644-43-2

SMILES

C[[email protected]@H](C1=C(C=CC=C1Cl)F)NC(C2=CC=C(N2C)C#N)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Nec-4
Cat. No.:
HY-18900
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Nec-4

Cat. No.: HY-18900