Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
Rho-kinase II
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "Rho-kinase II" in MCE Product Catalog:
584
584 Publications Verification
Research Areas:
Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor (ROCK-I Ki=220 nM; ROCK-II Ki=300 nM). Y-27632 dihydrochloride shows antiepileptic effects .
428
428 Cited Publications
Cat. No.: HY-10583R
CAS No.: 129830-38-2
Target:
Research Areas:
Y-27632 dihydrochloride (Standard) is the analytical standard of Y-27632 dihydrochloride. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor (ROCK-I Ki=220 nM; ROCK-II Ki=300 nM). Y-27632 dihydrochloride shows antiepileptic effects .
1
1 Cited Publications
Target:
Research Areas:
CAY10746 is a selective Rho kinase (ROCK) inhibitor. CAY10746 has inhibitory activity for ROCK I, ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively. CAY10746 can be used for the research of diabetic retinopathy (DR) .
Synonyms: PHP-201; AMA0076
Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil lowers intraocular pressure (IOP) without inducing hyperemia .
Synonyms: PHP-201 hydrochloride; AMA0076 hydrochloride
Target:
Research Areas:
Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hyperemia .
Research Areas:
NSC-2888 is a Rho kinase II (ROCK-II) inhibitor with an IC50 of 8.4 nM against human targets. NSC-2888 inhibits enzymatic activity by binding to active site amino acids via hydrogen bonds and hydrophobic interactions. NSC-2888 induces relaxation of pre-contracted rat aortic strips. NSC-2888 can be used in research related to hypertension .
Cat. No.: HY-109191AR
CAS No.: 2984963-50-8
Synonyms: PHP-201 hydrochloride (Standard); AMA0076 hydrochloride (Standard)
Target:
Research Areas:
Sovesudil hydrochloride (Standard) is the analytical standard of Sovesudil (hydrochloride) (HY-109191A). This product is intended for research and analytical applications. Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho Kinase (ROCK) inhibitor with IC50s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hyperemia .
Cat. No.: HY-P702931
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ROCK2; ROCK-II; Rho Associated Coiled-Coil Containing Protein kinase 2; Non-Specific Serine/Threonine Protein kinase; Rho-Associated, Coiled-Coil-Containing Protein kinase II; Rho-Associated Protein kinase; Rho-Associated Protein kinase 2; Rho kinase 2; P
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P705689
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ROCK2; ROCK-II; Rho Associated Coiled-Coil Containing Protein kinase 2; Non-Specific Serine/Threonine Protein kinase; Rho-Associated, Coiled-Coil-Containing Protein kinase II; Rho-Associated Protein kinase; Rho-Associated Protein kinase 2; Rho kinase 2; P
Species:
Human
Source:
Sf9 insect cells
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
