2. Disease Areas
  3. Blood or Cardio-cerebrovascular Disease
  4. Cardiovascular Disease
  5. Hypertension
  6. NSC-2888

NSC-2888 is a Rho kinase II (ROCK-II) inhibitor with an IC50 of 8.4 nM against human targets. NSC-2888 inhibits enzymatic activity by binding to active site amino acids via hydrogen bonds and hydrophobic interactions. NSC-2888 induces relaxation of pre-contracted rat aortic strips. NSC-2888 can be used in research related to hypertension.

For research use only. We do not sell to patients.

NSC-2888

NSC-2888 Chemical Structure

CAS No. : 5335-14-8

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NSC-2888 Related Antibodies

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Description

NSC-2888 is a Rho kinase II (ROCK-II) inhibitor with an IC50 of 8.4 nM against human targets. NSC-2888 inhibits enzymatic activity by binding to active site amino acids via hydrogen bonds and hydrophobic interactions. NSC-2888 induces relaxation of pre-contracted rat aortic strips. NSC-2888 can be used in research related to hypertension[1].

In Vitro

NSC-2888 induces vasodilation in isolated rat aortas with an IC50 of 8.5 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC-2888 Related Antibodies
Molecular Weight

210.36

Formula

C8H18O2S2
CAS No.
SMILES

OCCSCCC(C)SCCO
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NSC-2888 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC-28885335-14-8NSC2888NSC 2888vascular smooth muscleROCK-IIrat aortic stripsRho-kinase IIhypertensionInhibitorinhibitorinhibit

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