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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
Ryanodine Receptor 2
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "Ryanodine Receptor 2" in MCE Product Catalog:
Synonyms: ARM036; S44121
Target:
Research Areas:
Aladorian (ARM036; S44121) is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian improves cardiomyocyte Ca²⁺ homeostasis independent of dystrophin restoration. Aladorian attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy .
Cat. No.: HY-Z7733
CAS No.: 72956-44-6
Synonyms: Desmethylcarvedilol; BM-14242
Target:
Research Areas:
O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2 R4496C) mutation (IC50 = 7.62 µM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED50s = 32 and 5 µg/kg, respectively) .
Cat. No.: HY-164631
CAS No.: 714906-29-3
Target:
Research Areas:
EL20 is a selective cardiac ryanodine receptor 2 (RyR2) inhibitor. EL20 inhibits diastolic Ca
2+ leakage from the sarcoplasmic reticulum, reducing delayed afterdepolarizations and triggered arrhythmias. EL20 is promising for research of cardiovascular diseases .
Cat. No.: HY-119850A
CAS No.: 1233219-11-8
Synonyms: ARM036 sodium; S44121 sodium
Target:
Research Areas:
Aladorian (ARM036; S44121) sodium is a non-peptidic ryanodine receptor 2 (RyR2) stabilizer. Aladorian sodium stabilizes RyR2 channels and rectifies abnormal Ca²⁺ handling in cardiomyocytes. Aladorian sodium improves cardiomyocyte Ca 2+ homeostasis independent of dystrophin restoration. Aladorian sodium attenuates early cardiomyopathy and enhances left ventricular function in a canine muscular dystrophy model. Aladorian sodium can be used for the research of heart failure, Duchenne muscular dystrophy-associated cardiomyopathy and muscular dystrophy .
Cat. No.: HY-166478S
CAS No.: 1794817-24-5
Synonyms: Desmethylcarvedilol-d5; BM-14242-d5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
