Phospho-Ryanodine Receptor 2 (Ser2808) Antibody
(Synonyms: Ryanodine receptor 2, RYR-2, RyR2, hRYR-2, Cardiac muscle ryanodine receptor, Cardiac muscle ryanodine receptor-calcium release channel, Type 2 ryanodine receptor, RYR2)Based on 1 Customer Validation
Phospho-Ryanodine Receptor 2 (Ser2808) Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Phospho-Ryanodine Receptor 2 (Ser2808).
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat, Rabbit
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Formulation:
Supplied in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:100-200 | 1:100-500 |
Product Details
Phospho-Ryanodine Receptor 2 (Ser2808) Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Phospho-Ryanodine Receptor 2 (Ser2808).
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat, Rabbit
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Observed Molecular WeightObserved band size: 565 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 564 kDa
Synthetic phosphopeptide corresponding to residues surrounding S2808 of human Ryanodine Receptor 2 protein.
Endogenous
affinity purified.
Non-conjugated
Phosphorylated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Ryanodine Receptor 2 is a Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development
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Subcellular Localization
Sarcoplasmic reticulum membrane
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Expression
Tissue_Specificity: Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta.
Induction: By TGFB1. -
Isoforms & Post-Translational Modification
Phospho-Ryanodine Receptor 2 has 2 isoforms, Q92736-1: amino acid length is 4967, molecular weight is 564567 Da (predicted); Q92736-2: amino acid length is 4975, molecular weight is 565411 Da (predicted).
Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2808 and Ser-2814 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels. -
Subunit
Homotetramer.
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SwissProt ID
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Synonyms
Ryanodine receptor 2, RYR-2, RyR2, hRYR-2, Cardiac muscle ryanodine receptor, Cardiac muscle ryanodine receptor-calcium release channel, Type 2 ryanodine receptor, RYR2
Documentation
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