SOCS-1

By Targets:	Apoptosis (1) COX (2) DNA/RNA Synthesis (1) E1/E2/E3 Enzyme (1) IFNAR (1) Interleukin Related (3) JAK (2) Keap1-Nrf2 (1) Lipase (1) MMP (2) NF-κB (3) NO Synthase (3) p38 MAPK (1) PROTACs (1) Small Interfering RNA (siRNA) (3) STAT (1) TNF Receptor (2) Toll-like Receptor (TLR) (2) VEGFR (2)
By Research Areas:	Cancer (4) Infection (2) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10373

pJAK2(1001-1013)	JAK IFNAR Interleukin Related	Infection Inflammation/Immunology
pJAK2(1001-1013) is a cell-penetrating peptide that corresponds to the activation loop of JAK2 tyrosine kinase and functions as a *SOCS1/3*antagonist. pJAK2 (1001-1013) blocks SOCS1-mediated negative regulation of immune function, and enhances the biological activity of cytokines such as IFNγ and IL6. pJAK2(1001-1013) inhibits the replication of a broad range of viruses and exerts dose-dependent protective efficacy against lethal viral infections. pJAK2(1001-1013) can be used for the study of immune regulation and infection ^[1] .

HY-RS17712

Socs1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Socs1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Socs1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Socs1 Mouse Pre-designed siRNA Set A Socs1 Mouse Pre-designed siRNA Set A

HY-118828B

12-Oxo phytodienoic acid (≥90%) 1 Publications Verification 12-OPDA (≥90%)	NF-κB p38 MAPK TNF Receptor Interleukin Related NO Synthase Keap1-Nrf2	Neurological Disease Inflammation/Immunology
12-Oxo phytodienoic acid (≥90%) (12-OPDA (≥90%)) is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid (≥90%) induces the expression of *SOCS-1* and inhibits LPS (HY-D1056)-induced activation of the NF-κB and p38 MAPK signaling pathways. 12-Oxo phytodienoic acid (≥90%) inhibits LPS-induced expression of IL-6 and TNF-α, and reduces LPS-induced NO production by decreasing iNOS levels. 12-Oxo phytodienoic acid (≥90%) induces activation of the Nrf2 signaling cascade. 12-Oxo phytodienoic acid (≥90%) can be used for the research of neurodegenerative diseases ^[1].

HY-N7700A

Guluronic acid sodium 1 Publications Verification G2013 sodium	VEGFR Toll-like Receptor (TLR) COX NO Synthase NF-κB MMP	Inflammation/Immunology Cancer
Guluronic acid (G2013) sodium is an orally active oxidative stress regulator and anti-inflammatory agent that exerts pharmacological effects by down-regulating various pro-inflammatory and oxidative stress-related genes (such as TLR4, NF-κB, iNOS, etc.) and inhibiting the activities of COX-2, MMPs and VEGF. Low-dose Guluronic acid sodium up-regulates the expression of immunoregulatory genes *SHIP1* and *SOCS1*, thereby effectively inhibiting cancer-related inflammation, tumor angiogenesis, cell adhesion and metastasis, while reducing the accumulation of immunosuppressive cells. Guluronic acid sodium significantly prolongs the survival time of tumor-bearing hosts within a concentration range without direct cytotoxicity, demonstrating favorable safety. Guluronic acid sodium has involved in the research of multiple sclerosis, ankylosing spondylitis, breast cancer and other inflammatory diseases ^[1] .

HY-N7700

Guluronic acid G2013	MMP COX VEGFR Toll-like Receptor (TLR) NF-κB NO Synthase	Inflammation/Immunology Cancer
Guluronic acid (G2013) is an orally active oxidative stress regulator and anti-inflammatory agent that exerts pharmacological effects by down-regulating various pro-inflammatory and oxidative stress-related genes (such as TLR4, NF-κB, iNOS, etc.) and inhibiting the activities of COX-2, MMPs and VEGF. Low-dose Guluronic acid up-regulates the expression of immunoregulatory genes *SHIP1* and *SOCS1*, thereby effectively inhibiting cancer-related inflammation, tumor angiogenesis, cell adhesion and metastasis, while reducing the accumulation of immunosuppressive cells. Guluronic acid significantly prolongs the survival time of tumor-bearing hosts within a concentration range without direct cytotoxicity, demonstrating favorable safety. Guluronic acid has involved in the research of multiple sclerosis, ankylosing spondylitis, breast cancer and other inflammatory diseases ^[1] .

HY-RS13552

SOCS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SOCS1 Human Pre-designed siRNA Set A contains three designed siRNAs for SOCS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SOCS1 Human Pre-designed siRNA Set A SOCS1 Human Pre-designed siRNA Set A

HY-172535

Lipid OA2 dihydrochloride	Lipase	Inflammation/Immunology Cancer
Lipid OA2 dihydrochloride is an ionizable cationic lipid that can be used to prepare single-component lipid nanoparticles for siRNA delivery. Lipid OA2 dihydrochloride can effectively deliver SOCS1-siRNA to dendritic cells, silence the SOCS1 gene, and enhance their antigen-presenting ability and pro-inflammatory factor secretion capacity ^[1].

HY-RS24177

Socs1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Socs1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Socs1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Socs1 Rat Pre-designed siRNA Set A Socs1 Rat Pre-designed siRNA Set A

HY-124665

LMP-420	TNF Receptor Interleukin Related	Infection Metabolic Disease Inflammation/Immunology
LMP-420 is a selective tumor necrosis factor-α (TNF-α) inhibitor. LMP-420 reduces the release of pro-inflammatory cytokines (e.g., IL-1β, IL-2), inducing the expression of anti-inflammatory cytokine IL-10 and anti-apoptotic molecules SOCS-1 and Mn-SOD. LMP-420 also downregulates chemokines (e.g., IP-10, MCP-1) to reduce immune cell infiltration. LMP-420 is promising for research of type 1 diabetes mellitus, inflammatory diseases (e.g., colitis), and HIV-Mycobacterium tuberculosis coinfection ^[1].

HY-181653

PROTAC SKP2 Degrader-1	PROTACs E1/E2/E3 Enzyme DNA/RNA Synthesis JAK STAT Apoptosis	Cancer
PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K_d value of 6.28 μM. PROTAC SKP2 Degrader-1 induces targeted degradation of SKP2 via the ubiquitin-proteasome system. PROTAC SKP2 Degrader-1 stabilizes the expression of *SOCS1* and regulates the expression of immunoproteasomes through the JAK/STAT pathway, thereby inhibiting tumor cell proliferation. PROTAC SKP2 Degrader-1 is applicable for cancer-related research ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P10373

pJAK2(1001-1013)	JAK IFNAR Interleukin Related	Infection Inflammation/Immunology
pJAK2(1001-1013) is a cell-penetrating peptide that corresponds to the activation loop of JAK2 tyrosine kinase and functions as a *SOCS1/3*antagonist. pJAK2 (1001-1013) blocks SOCS1-mediated negative regulation of immune function, and enhances the biological activity of cytokines such as IFNγ and IL6. pJAK2(1001-1013) inhibits the replication of a broad range of viruses and exerts dose-dependent protective efficacy against lethal viral infections. pJAK2(1001-1013) can be used for the study of immune regulation and infection ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7700A

Guluronic acid sodium 1 Publications Verification G2013 sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	VEGFR Toll-like Receptor (TLR) COX NO Synthase NF-κB MMP
Guluronic acid (G2013) sodium is an orally active oxidative stress regulator and anti-inflammatory agent that exerts pharmacological effects by down-regulating various pro-inflammatory and oxidative stress-related genes (such as TLR4, NF-κB, iNOS, etc.) and inhibiting the activities of COX-2, MMPs and VEGF. Low-dose Guluronic acid sodium up-regulates the expression of immunoregulatory genes *SHIP1* and *SOCS1*, thereby effectively inhibiting cancer-related inflammation, tumor angiogenesis, cell adhesion and metastasis, while reducing the accumulation of immunosuppressive cells. Guluronic acid sodium significantly prolongs the survival time of tumor-bearing hosts within a concentration range without direct cytotoxicity, demonstrating favorable safety. Guluronic acid sodium has involved in the research of multiple sclerosis, ankylosing spondylitis, breast cancer and other inflammatory diseases ^[1] .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71785

	SOCS1 Protein, Human (P.pastoris, His) CISH 1; CISH1; Cytokine inducible SH2 protein 1; JAB; JAK binding protein; JAK-binding protein; Janus kinase binding protein ; SOCS 1; TEC interacting protein 3; Tec-interacting protein 3; TIP 3	Human	P. pastoris
	The SOCS1 protein is an important negative regulator that inhibits type I and type II interferon signaling as well as cytokines such as IL2, IL4, IL6, and LIF. It downregulates the signaling of the JAK/STAT pathway by inhibiting JAK proteins and IFNGR1. SOCS1 Protein, Human (P.pastoris, His) is the recombinant human-derived SOCS1 protein, expressed by P. pastoris , with N-His labeled tag.

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Host:	Mouse (1) Rabbit (1)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (1) IHC-F (1) WB (2) ELISA (1)
Isotype:	IgG (1)
Conjugation:	Non-conjugated (2)
Clonality:	Polyclonal (1) Monoclonal (1)
Modification:	Unmodified (2)

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HY-P85715

	SOCS-1 Antibody (YA5407) Suppressor of cytokine signaling 1; SOCS-1; JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; TIP-3;	IHC-P, WB	Human, Mouse, Rat
	SOCS-1 Antibody (YA5407) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to SOCS-1.

HY-P80897

	SOCS-1 Antibody SOCS1; SSI1; TIP3; Suppressor of cytokine signaling 1; SOCS-1; JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; TIP-3	ICC/IF, WB, IHC-F, IHC-P, ELISA	Human, Mouse, Rat
	SOCS-1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to SOCS-1.

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Cat. No.	Product Name		Classification

HY-RS17712

Socs1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Socs1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Socs1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS13552

SOCS1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SOCS1 Human Pre-designed siRNA Set A contains three designed siRNAs for SOCS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24177

Socs1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Socs1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Socs1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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