SOCS1 Protein, Human (P.pastoris, His)

The SOCS1 protein is an important negative regulator that inhibits type I and type II interferon signaling as well as cytokines such as IL2, IL4, IL6, and LIF. It downregulates the signaling of the JAK/STAT pathway by inhibiting JAK proteins and IFNGR1. SOCS1 Protein, Human (P.pastoris, His) is the recombinant human-derived SOCS1 protein, expressed by P. pastoris , with N-His labeled tag. The total length of SOCS1 Protein, Human (P.pastoris, His) is 211 a.a., with molecular weight of ~25.6 kDa.

SOCS1 Protein is an essential negative regulator of type I and type II interferon (IFN) signaling, along with other cytokines such as IL2, IL4, IL6, and leukemia inhibitory factor (LIF). It downregulates cytokine signaling by inhibiting the JAK/STAT pathway, binding to JAK proteins and IFNGR1 to inhibit their kinase activity. Additionally, SOCS1 suppresses Tec protein-tyrosine activity in vitro and plays a role in regulating IFN-gamma (IFNG)-mediated sensory neuron survival. It is also a probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex, contributing to the ubiquitination and subsequent proteasomal degradation of target proteins through protein modification.

Human

P. pastoris

N-His

O15524 (1M-211I)

8651  [NCBI]

MVAHNQVAADNAVSTAAEPRRRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRASALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRESFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVATVGRENLARIPLNPVLRDYLSSFPFQI

Approximately 25.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.