473870-63-2
Chemical Structure
LMP-420
- CAS No.: 473870-63-2
- Formula:C10H15BClN5O2
- Molecular Weight:283.52
IUPAC Name: (5-(2-amino-6-chloro-9H-purin-9-yl)pentyl)boronic acid
InChIKey: SPLHPRPQTCQRGZ-UHFFFAOYSA-N
SMILES: ClC1=C2N=CN(CCCCCB(O)O)C2=NC(N)=N1
Biological Activity: LMP-420 is a selective tumor necrosis factor-α (TNF-α) inhibitor. LMP-420 reduces the release of pro-inflammatory cytokines (e.g., IL-1β, IL-2), inducing the expression of anti-inflammatory cytokine IL-10 and anti-apoptotic molecules SOCS-1 and Mn-SOD. LMP-420 also downregulates chemokines (e.g., IP-10, MCP-1) to reduce immune cell infiltration. LMP-420 is promising for research of type 1 diabetes mellitus, inflammatory diseases (e.g., colitis), and HIV-Mycobacterium tuberculosis coinfection[1].
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LMP-420 | LMP-420 is a selective tumor necrosis factor-α (TNF-α) inhibitor. LMP-420 reduces the release of pro-inflammatory cytokines (e.g., IL-1β, IL-2), inducing the expression of anti-inflammatory cytokine IL-10 and anti-apoptotic molecules SOCS-1 and Mn-SOD. LMP-420 also downregulates chemokines (e.g., IP-10, MCP-1) to reduce immune cell infiltration. LMP-420 is promising for research of type 1 diabetes mellitus, inflammatory diseases (e.g., colitis), and HIV-Mycobacterium tuberculosis coinfection. | |||||||||||||||||||||
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