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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
Spiramycin I
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "Spiramycin I" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-N7141
CAS No.: 24916-50-5
Category:
Infection Microorganisms Macrolide Antibiotics Antibiotics Anti-parasitic Disease Research Disease Research Fields
Target:
Cat. No.: HY-120809A
Category:
Target:
Cat. No.: HY-N7141R
CAS No.: 24916-50-5
Cat. No.: HY-143623S
Cat. No.: HY-W890109S
CAS No.: 1355452-20-8
Cat. No.: HY-W587414
CAS No.: 70253-62-2
Target:
Research Areas:
Neospiramycin I is a macrolide antibiotic and a derivative of Spiramycin I (HY-N7141). Neospiramycin I is effective against the macrolide-sensitive KB210 strain of S. aureus, but ineffective against the macrolide-resistant KB224 strain, with minimum inhibitory concentrations (MIC) of 3.12 and greater than 100 µg/mL, respectively; it is also effective against B. cereus, B. subtilis, M. luteus, E. coli, and K. pneumoniae, with respective MIC values of 1.56, 3.12, 3.12, 0.2, 50, and 12.5 µg/mL. Neospiramycin I binds to the ribosomes of E. coli, with an inhibitory concentration 50 (IC50) of 1.2 µM. It protects mice from death in a type III S. pneumoniae infection model, with an effective dose 50 (ED50) of 399.8 mg/kg .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
