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Results for "

Syrian hamsters

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) AMPK (1) Androgen Receptor (2) Apoptosis (2) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (2) C-type Lectin-like Receptors (CTLRs) (1) CD28 (1) CTLA-4 (1) DNA Methyltransferase (1) DNA/RNA Synthesis (2) Drug Derivative (1) Drug Metabolite (1) Fc Receptor (FcR) (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Keap1-Nrf2 (1) LDLR (1) Mitochondrial Metabolism (1) NF-κB (2) p38 MAPK (1) PI3K (1) Reactive Oxygen Species (ROS) (1) ROCK (1) SARS-CoV (7) Ser/Thr Protease (1) Transmembrane Glycoprotein (1) Virus Protease (4) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Endocrinology (3) Infection (8) Inflammation/Immunology (8) Metabolic Disease (3) Neurological Disease (1)

By Targets:

Akt (1)

AMPK (1)

Androgen Receptor (2)

Apoptosis (2)

Autophagy (1)

Bacterial (1)

Biochemical Assay Reagents (2)

C-type Lectin-like Receptors (CTLRs) (1)

CD28 (1)

CTLA-4 (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (2)

Drug Derivative (1)

Drug Metabolite (1)

Fc Receptor (FcR) (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Keap1-Nrf2 (1)

LDLR (1)

Mitochondrial Metabolism (1)

NF-κB (2)

p38 MAPK (1)

PI3K (1)

Reactive Oxygen Species (ROS) (1)

ROCK (1)

SARS-CoV (7)

Ser/Thr Protease (1)

Transmembrane Glycoprotein (1)

Virus Protease (4)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (4)

Cardiovascular Disease (1)

Endocrinology (3)

Infection (8)

Inflammation/Immunology (8)

Metabolic Disease (3)

Neurological Disease (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-172437

Secutrelvir S-892216	Virus Protease SARS-CoV	Infection
Secutrelvir is an oral SARS-CoV-2 3C-like protease (3CLpro) inhibitor and antiviral agent, with IC₅₀ values of 0.655 nM and 0.697 nM against SARS-CoV-2 3CLpro, respectively. Secutrelvir forms a reversible covalent bond with the catalytic cysteine C145 of SARS-CoV-2 3CLpro, thereby inhibiting viral replication. Secutrelvir exhibits activity against multiple SARS-CoV-2 variants and can be used in research related to coronavirus disease 2019 (COVID-19) .

HY-W039315

2,5-Anhydro-D-mannitol, 97%	Biochemical Assay Reagents	Metabolic Disease
2,5-Anhydro-D-mannitol, 97% is an antimetabolic fructose analogue. 2,5-Anhydro-D-mannitol, 97% depletes intracellular ATP, reduces oxygen consumption, regulates substrate oxidation, increases phosphomonoester levels, decreases inorganic phosphate levels, and promotes the release of intracellular calcium from intracellular calcium stores via phospholipase C-dependent activity in hepatocytes .

HY-172760

CIM-834	SARS-CoV	Infection
CIM-834 is an orally effective inhibitor of SARS-CoV-2 membrane protein. CIM-834 can prevent the assembly of infectious virus particles without inhibiting the synthesis of viral RNA. CIM-834 can reduce the viral titer in the lungs of SCID mice infected nasally with SARS-CoV-2, block the spread of SARS-CoV-2 among Syrian hamsters, and inhibit the replication of SARS-CoV-2 (including variants) and SARS-CoV. CIM-834 can be used in related research on COVID-19 .

HY-N0430

Coptisine Coptisin	Indoleamine 2,3-Dioxygenase (IDO) NF-κB p38 MAPK PI3K Akt Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism DNA/RNA Synthesis ROCK LDLR	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Coptisine is an orally active and brain-penetrant alkaloid found in Coptis chinensis. Coptisine is a reversible, uncompetitive IDO inhibitor with a K_i of 5.8 μM and an IC₅₀ of 6.3 μM. Coptisine suppresses neuroinflammation, reduces Aβ plaque burden and shows neuroprotective activity. Coptisine shows anti-inflammation activity by blocking NF-κB, MAPK, and PI3K/Akt activation. Coptisine inhibits cancer cells proliferation, induces DNA damage, G2/M phase cell cycle arrest, apoptosis, ROS production and mitochondrial dysfunction. Coptisine inhibits Rho/ROCK pathway activation, reduces arrhythmia, limits cardiac injury marker release, reduces infarct size, and preserves cardiac function in rat myocardial ischemia/reperfusion models. Coptisine downregulates HMGCR and upregulates LDLR and CYP7A1 to modulate cholesterol metabolism, reduces abnormal serum lipid levels, and promotes fecal bile acid excretion. Coptisine can be used for the research of cancer, hypercholesterolemia, Alzheimer’s disease, inflammatory disorders and cardiovascular disease .

HY-P99123

Anti-Mouse CD28 Antibody (37.51) 2 Publications Verification	CD28	Inflammation/Immunology
Anti-Mouse CD28 Antibody (37.51) is an agonistic agonistic CD28-specific antibody derived from the host Syrian Hamster. Anti-Mouse CD28 Antibody (37.51) partially prevents lethal graft-versus-hostdisease (GVHD) by selective depletion of alloreactive T cells in mice .

HY-P990789

Anti-Mouse CTLA-4 Antibody (9H10)	CTLA-4	Others Inflammation/Immunology Cancer
Anti-Mouse CTLA-4 Antibody (9H10) is a kind of syrian hamster IgG antibody inhibitor, targeting to CTLA-4. Anti-Mouse CTLA-4 Antibody (9H10) binds mouse CTLA-4 and blocks the interaction between CTLA-4 and its ligand. Anti-Mouse CTLA-4 Antibody (9H10) shows potent anti-tumor effect in various tumor models, such as breast and colon cancer .

HY-173521

JNJ-9676	SARS-CoV DNA/RNA Synthesis Virus Protease	Infection
JNJ-9676 is an orally active Coronavirus M protein inhibitor and selective Sarbecovirus inhibitor. JNJ-9676 binds to the M protein dimer and forces the protein into an alternative conformational state with a compound-induced binding pocket. JNJ-9676 demonstrates in vitro nanomolar antiviral activity against SARS-CoV-2, SARS-CoV and Sarbecovirus strains from bat and pangolin zoonotic origin .

HY-N11722

Panduratin A	Apoptosis NF-κB Keap1-Nrf2 AMPK Autophagy SARS-CoV DNA Methyltransferase	Infection Inflammation/Immunology Endocrinology
Panduratin A is an orally active natural compound with multiple pharmacological activities. By specifically inhibiting the NF-κB signaling pathway, Panduratin A exerts potent anti-inflammatory and antioxidant effects in intestinal and vascular inflammation models. Panduratin A exerts a definite protective effect against Colistin (HY-113678)-induced nephrotoxicity by alleviating oxidative stress, improving mitochondrial dysfunction and inhibiting cell apoptosis. Panduratin A activates autophagy via an AMPK-dependent pathway and exhibits anti-tuberculosis activity. Panduratin A exerts antiviral effects by inhibiting the methyltransferase (DNA Methyltransferase) of SARS-CoV-2 .

HY-170309

NZ-804	SARS-CoV Virus Protease	Infection
NZ-804 is an orally active inhibitor for SARS-CoV-2 main protease Mpro with an IC₅₀ of 8.9 nM. NZ-804 inhibits the SARS-CoV-2 replication in HeLa-hACE2 cell with an EC₅₀ of 14 nM. NZ-804 exhibits board-spectrum antiviral activity aganst multiple CoVs. NZ-804 diminishes virus replication in mouse and hamster model .

HY-160659

Androgen receptor antagonist 10	Androgen Receptor	Endocrinology
Androgen receptor antagonist 10 (compound 6h) is a androgen receptor antagonist. Androgen receptor antagonist 10 reduces the wax esters in the golden syrian hamster model .

HY-175344

TMP1	SARS-CoV Virus Protease Ser/Thr Protease	Infection Inflammation/Immunology
TMP1 is an orally active bispecific inhibitor of M pro (IC₅₀ = 312.5 nM)/TMPRSS2 (IC₅₀ = 1.28 μM, K_D = 10.10 μM). TMP1 exhibits broad protection against different SARS-CoV-2 variants in vitro. TMP1 cross-protects against highly pathogenic coronaviruses (SARS-CoV-1, SARS-CoV-2, and MERS-CoV) in vivo and effectively blocks the transmission of SARS-CoV-2. TMP1 can inhibit infection by SARS-CoV-2 escape mutants that are resistant to Nivolumab (HY-P9903). TMP1 can be used in coronavirus research .

HY-P991043

Syrian Hamster IgG, Isotype Control	Fc Receptor (FcR)	Inflammation/Immunology
Syrian Hamster IgG, Isotype Control is the syrian hamster antibody that is the isotype control of Syrian Hamster IgG antibody.

HY-168924

Wnt/β-catenin activator 1	Wnt β-catenin	Metabolic Disease
Wnt/β-catenin activator 1 (Compound 5m) is the orally active activator for Wnt/β-catenin signaling pathway, that arrests cell cycle at G1 phase, inhibits early proliferation of adipocytes, and inhibits adipogenesis in cell 3T3-L1 with an IC₅₀ of 330 nM. Wnt/β-catenin activator 1 exhibits anti-adipogenic and anti-dyslipidemic activities in high-fat diet fed Syrian golden hamster model .

HY-160680

AR antagonist 6	Androgen Receptor	Endocrinology
AR antagonist 6 (compound 6i) is a diphenyl ether androgen receptor (AR) antagonist that binds AR at a concentration of 120 nM. AR antagonist 6 exhibits low toxicity and in vitro activity against the golden Syrian hamster ear model .

HY-P990168

Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1)	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) is a Syrian hamster-derived IgG type antibody inhibitor, targeting to mouse Podoplanin/glycoprotein 38. Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) blocks podoplanin binding to C-type lectin receptor CLEC-2. Anti-Mouse Podoplanin/glycoprotein 38 Antibody (8.1.1) can be used for the research of cancer and inflammation, such as lung inflammation .

HY-P990205

Anti-Mouse/Human KLRG-1 Antibody (2F1)	C-type Lectin-like Receptors (CTLRs)	Inflammation/Immunology
Anti-Mouse/Human KLRG-1 Antibody (2F1) is a Syrian hamster-derived IgG type antibody inhibitor, targeting to mouse/human KLRG-1. Anti-Mouse/Human KLRG-1 Antibody (2F1) neutralizes KLRG1. Anti-Mouse/Human KLRG-1 Antibody (2F1) reduces T-cell receptor signals and regulatory T-cell accumulation. Anti-Mouse/Human KLRG-1 Antibody (2F1) can be used for the researches of immunology .

HY-W209580

N-Nitrosobis(2-oxopropyl)amine	Drug Derivative	Cancer
N-Nitrosobis (2-oxopropyl) amine is a nitrosamine compound that has been the subject of significant research interest in the field of chemical carcinogenesis. N-nitrosobis (2-oxopropyl) amine (BOP) -treated Syrian golden hamsters are a chemical carcinogenesis model that represents human pancreatic cancer.

HY-W777236

N-Acetyl serotonin β-D-glucuronide	Drug Metabolite	Others
N-Acetyl serotonin β-D-glucuronide is a glucuronidated metabolite of N-acetylserotonin (HY-107854) and a probe metabolite for UGT1A6 activity assays.N-Acetyl serotonin β-D-glucuronide forms from N-acetyl serotonin via glucuronidation catalyzed by a UGT enzyme .

HY-B2232A

Benzalkonium chloride (solid) 2 Publications Verification Alkyldimethylbenzylammonium chloride (solid)	Biochemical Assay Reagents Bacterial	Infection
Benzalkonium chloride (solid) (Alkyldimethylbenzylammonium chloride (solid)) is a quaternary ammonium preservative, cationic surfactant, and antimicrobial (Antimicrobial) agent. Benzalkonium chloride (solid) is toxic .

HY-183185

BZ-30	SARS-CoV	Infection
BZ-30 is an orally active broad-spectrum SARS-CoV-2 inhibitor. BZ-30 acts on the early stage of the viral life cycle, can partially inhibit the endosomal entry process and reduce viral replication levels. BZ-30 reduces viral load, improves pulmonary pathological conditions, and decreases the lung-to-body weight ratio in hamster models challenged with SARS-CoV-2. BZ-30 can be used for research related to COVID-19 .

2,5-Anhydro-D-mannitol, 97%	Biochemical Assay Reagents
2,5-Anhydro-D-mannitol, 97% is an antimetabolic fructose analogue. 2,5-Anhydro-D-mannitol, 97% depletes intracellular ATP, reduces oxygen consumption, regulates substrate oxidation, increases phosphomonoester levels, decreases inorganic phosphate levels, and promotes the release of intracellular calcium from intracellular calcium stores via phospholipase C-dependent activity in hepatocytes .

Cat. No.	Product Name	Target	Research Area	Image