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Cat. No.: HY-160659

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Androgen receptor antagonist 10

Androgen receptor antagonist 10 (compound 6h) is a androgen receptor antagonist. Androgen receptor antagonist 10 reduces the wax esters in the golden syrian hamster model.

For research use only. We do not sell to patients.

CAS No.: 876759-87-4
Formula: C₁₅H₁₀F₃NOS
Molecular Weight:309.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Androgen receptor antagonist 10 Chemical Structure

CAS No.: 876759-87-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Androgen receptor antagonist 10 (compound 6h) is a androgen receptor antagonist. Androgen receptor antagonist 10 reduces the wax esters in the golden syrian hamster model^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	IC₅₀	22 nM Compound: 6h	Antagonist activity at human androgen receptor expressed in human MDA-MB-231 cells assessed as inhibition of DHT-induced response Antagonist activity at human androgen receptor expressed in human MDA-MB-231 cells assessed as inhibition of DHT-induced response	[PMID: 19286380]
Sf9	IC₅₀	74 nM Compound: 6h	Displacement of [3H]DHT from human cloned androgen receptor expressed in insect Sf9 cell system Displacement of [3H]DHT from human cloned androgen receptor expressed in insect Sf9 cell system	[PMID: 19286380]

Chemical Information

CAS No. 876759-87-4
Molecular Weight 309.31
Formula C₁₅H₁₀F₃NOS
SMILES

CSC1=CC=CC=C1OC2=CC(C(F)(F)F)=C(C#N)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mitchell LH, et al. Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009;19(8):2176-2178. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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