41107-82-8
Chemical Structure
2,5-Anhydro-D-mannitol, 97%
- CAS. Nr.: 41107-82-8
- Formula:C6H12O5
- Molecular Weight:164.16
IUPAC Name: (2R,3S,4S,5R)-2,5-bis(hydroxymethyl)tetrahydrofuran-3,4-diol
InChIKey: MCHWWJLLPNDHGL-KVTDHHQDSA-N
SMILES: OC[C@@H]1[C@H]([C@@H]([C@H](O1)CO)O)O
Biological Activity:
2,5-Anhydro-D-mannitol, 97% is an antimetabolic fructose analogue. 2,5-Anhydro-D-mannitol, 97% depletes intracellular ATP, reduces oxygen consumption, regulates substrate oxidation, increases phosphomonoester levels, decreases inorganic phosphate levels, and promotes the release of intracellular calcium from intracellular calcium stores via phospholipase C-dependent activity in hepatocytes[1][2][3].
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2,5-Anhydro-D-mannitol, 97% | 99.86% | 2,5-Anhydro-D-mannitol, 97% is an antimetabolic fructose analogue. 2,5-Anhydro-D-mannitol, 97% depletes intracellular ATP, reduces oxygen consumption, regulates substrate oxidation, increases phosphomonoester levels, decreases inorganic phosphate levels, and promotes the release of intracellular calcium from intracellular calcium stores via phospholipase C-dependent activity in hepatocytes. |
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Similarity Score 1.00
HY-W6984942,5-Anhydro-D-glucitol -
Similarity Score 0.89
HY-691741-Amino-2,5-anhydro-1-deoxy-D-mannitol -
Similarity Score 0.87
HY-113375D-Ribofuranose -
Similarity Score 0.83
HY-W039930Methyl β-D-ribofuranoside -
Similarity Score 0.83
HY-691752,5-Anhydro-D-mannose -
Similarity Score 0.82
HY-113075R1,5-Anhydrosorbitol (Standard) -
Similarity Score 0.82
HY-113075S1,5-Anhydrosorbitol-13C -
Similarity Score 0.82
HY-N99111,5-Anhydro-D-mannitol -
Similarity Score 0.82
HY-W7681811,5-Anhydrosorbitol-13C6 -
Explore the MedChemAI to find more analogs
References
- [1]. Ji H, et al. Interactions of dietary fat and 2,5-anhydro-D-mannitol on energy metabolism in isolated rat hepatocytes. Am J Physiol Regul Integr Comp Physiol. 2002;282(3):R715-R720. [Content Brief]
- [2]. Schneider JE, et al. Effects of the fructose analog, 2,5-anhydro-D-mannitol, on food intake and estrous cyclicity in Syrian hamsters. Am J Physiol. 1997;272(3 Pt 2):R935-R939. [Content Brief]
- [3]. Rawson NE, et al. 2,5-Anhydro-D-mannitol increases hepatocyte calcium: implications for a hepatic hunger stimulus. Biochim Biophys Acta. 2003;1642(1-2):59-66. [Content Brief]
