3026520-19-1
Chemical Structure
JNJ-9676
- CAS No.: 3026520-19-1
- Formula:C28H21F2N5O2
- Molecular Weight:497.50
InChIKey: XXXBMVUCPXBZMT-SFHVURJKSA-N
SMILES: N#CC1=CC=CC(NC(C2=C3N(N=C2)C[C@@H](N(C4=CC=C(C=C4)C(F)(C5=CC=CC=C5)F)C3=O)C)=O)=C1
Biological Activity: JNJ-9676 is an orally active Coronavirus M protein inhibitor and selective Sarbecovirus inhibitor. JNJ-9676 binds to the M protein dimer and forces the protein into an alternative conformational state with a compound-induced binding pocket. JNJ-9676 demonstrates in vitro nanomolar antiviral activity against SARS-CoV-2, SARS-CoV and Sarbecovirus strains from bat and pangolin zoonotic origin[1].
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JNJ-9676 | 99.74% | JNJ-9676 is an orally active Coronavirus M protein inhibitor and selective Sarbecovirus inhibitor. JNJ-9676 binds to the M protein dimer and forces the protein into an alternative conformational state with a compound-induced binding pocket. JNJ-9676 demonstrates in vitro nanomolar antiviral activity against SARS-CoV-2, SARS-CoV and Sarbecovirus strains from bat and pangolin zoonotic origin. | ||||||||||||||||||||
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Keywords
