Benzalkonium chloride (solid)
Based on 2 publication(s) in Google Scholar
Benzalkonium chloride (solid) (Alkyldimethylbenzylammonium chloride (solid)) is a quaternary ammonium preservative, cationic surfactant, and antimicrobial (Antimicrobial) agent. Benzalkonium chloride (solid) is toxic.
For research use only. We do not sell to patients.
- Purity: 99.00%
- CAS No.: 8001-54-5
- Formula: C6H5CH2N(CH3)2RCl (R=C8H17 to C18H37)
- Molecular Weight:184.69
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Benzalkonium chloride (solid)
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Biological Activity
Benzalkonium chloride (0.001%; intranasal administration; twice daily; 14 to 28 days) induces nasal epithelial degeneration in rabbits[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rabbits[1]
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Dosage:0.001%;
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Administration:intranasal; twice daily; 14 or 28 days
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Result:Induced degenerative changes, including squamous cell metaplasia, nuclei deformation, and increased heterochromatin, in the treated nasal epithelium.
Chemical Information
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CAS No. 8001-54-5
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Appearance Solid
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Molecular Weight 184.69
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Formula C6H5CH2N(CH3)2RCl (R=C8H17 to C18H37)
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Color White to off-white
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SMILES
C[N+](C[(CH2)nCH3])(C)CC1=CC=CC=C1.[Cl-].[n=].[6 -16]
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Synonyms
Alkyldimethylbenzylammonium chloride (solid)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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ACS Biomater Sci Eng
Mechanoresponsive Drug Loading System with Tunable Host-Guest Interactions for Ocular Disease Treatment. [Abstract]2022 Nov 14;8(11):4850-4862. PMID: 36214483 -
Int J Ophthalmol
Obtusifolin ameliorates dry eye model in rats by reducing inflammation and blocking MAPK/NF-κB pathways. [Abstract]2025 Aug 18;18(8):1426-1432. PMID: 40827285
Solvent & Solubility
DMSO : 100 mg/mL (541.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (27.07 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (27.07 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (615 KB)
- English - EN (615 KB)
- Français - FR (615 KB)
- Deutsch - DE (615 KB)
- Norwegian - NO (615 KB)
- Español - ES (615 KB)
- Swedish - SV (615 KB)
- Italian - IT (615 KB)
- Korean - KR (615 KB)
- Portuguese - PT (615 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.4145 mL | 27.0724 mL | 54.1448 mL | 135.3620 mL |
| 5 mM | 1.0829 mL | 5.4145 mL | 10.8290 mL | 27.0724 mL | |
| 10 mM | 0.5414 mL | 2.7072 mL | 5.4145 mL | 13.5362 mL | |
| 15 mM | 0.3610 mL | 1.8048 mL | 3.6097 mL | 9.0241 mL | |
| 20 mM | 0.2707 mL | 1.3536 mL | 2.7072 mL | 6.7681 mL | |
| 25 mM | 0.2166 mL | 1.0829 mL | 2.1658 mL | 5.4145 mL | |
| 30 mM | 0.1805 mL | 0.9024 mL | 1.8048 mL | 4.5121 mL | |
| 40 mM | 0.1354 mL | 0.6768 mL | 1.3536 mL | 3.3840 mL | |
| 50 mM | 0.1083 mL | 0.5414 mL | 1.0829 mL | 2.7072 mL | |
| 60 mM | 0.0902 mL | 0.4512 mL | 0.9024 mL | 2.2560 mL | |
| 80 mM | 0.0677 mL | 0.3384 mL | 0.6768 mL | 1.6920 mL | |
| 100 mM | 0.0541 mL | 0.2707 mL | 0.5414 mL | 1.3536 mL |
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