1. Anti-infection
  2. Bacterial
  3. Benzalkonium chloride

Benzalkonium chloride (Synonyms: Alkyldimethylbenzylammonium chloride)

Cat. No.: HY-B2232 Purity: ≥98.0%
Handling Instructions

Benzalkonium chloride is a potent anti-microbial agent, used as a preservative in eye drops.

For research use only. We do not sell to patients.

Benzalkonium chloride Chemical Structure

Benzalkonium chloride Chemical Structure

CAS No. : 8001-54-5

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Solution
50 mg (510 mg/mL * 98 μL in Water) USD 50 In-stock
Estimated Time of Arrival: December 31

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

Benzalkonium chloride is a potent anti-microbial agent, used as a preservative in eye drops.

In Vitro

Benzalkonium chloride (0.0001%-0.5%) results in a dose-dependent cytotoxicity in cells. Benzalkonium chloride also shows cytotoxicity against human keratinocytes, with 50% loss of viability of 4 μM. Benzalkonium chloride shows different results in NHEK and NB1RGB cell cultures, and the ED50 of 3.9 and 62 μM, respectively. The clinically used concentration (0.01% Benzalkonium chloride) significantly reduces cell viability, with only 14%-19% of nasal epithelial cells surviving the treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Benzalkonium chloride (0.02%) causes no abnormalities in the nasal epithelium of the monkeys after light and electron microscopical examination. In 4-5 week-old SD rats, 0.01% and 0.1% Benzalkonium chloride induce a time-dependent increase in the thickness of the nasal respiratory epithelium[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

283.88-424.15

Formula

C₆H₅CH₂N(CH₃)₂RCl (R=C₈H₁₇ to C₁₈H₃₇)

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Solution, -20°C, 2 years

Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (Need ultrasonic)

DMSO : 50 mg/mL (Need ultrasonic)

H2O : ≥ 20 mg/mL

*"≥" means soluble, but saturation unknown.

In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 120 mg/mL (Infinity mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.25 mg/mL (Infinity mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3.25 mg/mL (Infinity mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3.25 mg/mL (Infinity mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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Benzalkonium chloride
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HY-B2232
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