89837-52-5
Chemical Structure
Panduratin A
- CAS No.: 89837-52-5
- Formula:C26H30O4
- Molecular Weight:406.51
IUPAC Name: (2,6-dihydroxy-4-methoxyphenyl)((1R,2R,3S)-4-methyl-3-(3-methylbut-2-en-1-yl)-1,2,3,6-tetrahydro-[1,1'-biphenyl]-2-yl)methanone
InChIKey: LYDZCXVWCFJAKQ-ZFGGDYGUSA-N
SMILES: O=C(C1=C(C=C(C=C1O)OC)O)[C@H]2[C@H](C3=CC=CC=C3)CC=C([C@H]2C/C=C(C)\C)C
Biological Activity: Panduratin A is an orally active natural compound with multiple pharmacological activities. By specifically inhibiting the NF-κB signaling pathway, Panduratin A exerts potent anti-inflammatory and antioxidant effects in intestinal and vascular inflammation models. Panduratin A exerts a definite protective effect against Colistin (HY-113678)-induced nephrotoxicity by alleviating oxidative stress, improving mitochondrial dysfunction and inhibiting cell apoptosis. Panduratin A activates autophagy via an AMPK-dependent pathway and exhibits anti-tuberculosis activity. Panduratin A exerts antiviral effects by inhibiting the methyltransferase (DNA Methyltransferase) of SARS-CoV-2[1][2][3][4][5].
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Panduratin A | 99.9% | Panduratin A is an orally active natural compound with multiple pharmacological activities. By specifically inhibiting the NF-κB signaling pathway, Panduratin A exerts potent anti-inflammatory and antioxidant effects in intestinal and vascular inflammation models. Panduratin A exerts a definite protective effect against Colistin (HY-113678)-induced nephrotoxicity by alleviating oxidative stress, improving mitochondrial dysfunction and inhibiting cell apoptosis. Panduratin A activates autophagy via an AMPK-dependent pathway and exhibits anti-tuberculosis activity. Panduratin A exerts antiviral effects by inhibiting the methyltransferase (DNA Methyltransferase) of SARS-CoV-2. | ||||||||||||||||||||
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- [1]. Alqudah A, et al. Panduratin A mitigates inflammation and oxidative stress in DSS-induced colitis mice model. Future Sci OA. 2024;10(1):2428129. [Content Brief]
- [2]. Kiatsoonthon K, et al. Panduratin A Inhibits TNF Alpha-Stimulated Endothelial Cell Activation Through Suppressing the NF-κB Pathway. Biomolecules. 2024;15(1):34. Published 2024 Dec 30. [Content Brief]
- [3]. Lamtha T, et al. Panduratin A Induces Autophagy Through AMPK Activation Independent of mTOR Inhibition and Restricts Mycobacterium tuberculosis in Host Macrophages. Mol Microbiol. 2025;124(6):491-506. [Content Brief]
- [4]. Boonserm P, et al. A computational study on the molecular mechanisms of panduratin A as a potential inhibitor on SARS-CoV-2 protein targets. Heliyon. 2023;9(1):e12780. [Content Brief]
- [5]. Worakajit N, et al. Nephroprotective potential of Panduratin A against colistin-induced renal injury via attenuating mitochondrial dysfunction and cell apoptosis. Biomed Pharmacother. 2022;148:112732. [Content Brief]
Keywords
