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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
71 Results for "
TAC
" in MedChemExpress (MCE) Product Catalog:
Products (71)
71 Results for "TAC" in MCE Product Catalog:
2
2 Cited Publications
Target:
Research Areas:
CXCR7 antagonist-1 is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases .
2
2 Cited Publications
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FC9402 is a potent and selective sulfide quinone oxidoreductase (SQOR) inhibitor extracted from patent WO 2020/146636 A1. FC9402 attenuates TAC-induced cardiomyocyte hypertrophy and left ventricle (LV) fibrosis. FC9402 can be used for cardiovascular regulation .
2
2 Cited Publications
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CXCR7 antagonist-1 hydrochloride is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 hydrochloride is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases .
1
Category:
1
1 Cited Publications
Cat. No.: HY-P7229
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL11; Interferon Gamma-Inducible Protein 9; Prev. SCYB11; C-X-C Motif Chemokine 11; Prev. SCYB9B; Beta-R1; I-TAC; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 9B; H174; Small Inducible Cytokine B11; IP-9; Small-Inducible Cytokine B11; B-R1;
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P700169AF
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL11; Interferon Gamma-Inducible Protein 9; Prev. SCYB11; C-X-C Motif Chemokine 11; Prev. SCYB9B; Beta-R1; I-TAC; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 9B; H174; Small Inducible Cytokine B11; IP-9; Small-Inducible Cytokine B11; B-R1;
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P7228
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CXCL11; Interferon Gamma-Inducible Protein 9; Prev. SCYB11; C-X-C Motif Chemokine 11; Prev. SCYB9B; Beta-R1; I-TAC; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 9B; H174; Small Inducible Cytokine B11; IP-9; Small-Inducible Cytokine B11; B-R1; Alternative Protein CXCL11; Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 11; ITAC; Interferon-Inducible T-Cell Alpha Chemoattractant; IP9; C-X-C Motif Chemokine Ligand 11; Chemokine (C-X-C Motif) Ligand 11
Species:
Human
Source:
HEK293
Synonyms: RG6091; RO7248824
Target:
Research Areas:
Rugonersen (RG6091; RO7248824) is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .
Cat. No.: HY-P99233
CAS No.: 921618-45-3
Synonyms: HuMax-TAC
Research Areas:
Cat. No.: HY-174400
Target:
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SGLT2-IN-2 (Compound E9) is an inhibitor of SGLT2. SGLT2-IN-2 significantly enhances the inhibition of SGLT2, NHE1, and SOD enzyme activity. SGLT2-IN-2 has protective effect on the glucose-free DMEM-induced injured cardiomyocytes. SGLT2-IN-2 significantly improves cardiac function in TAC-induced HF mice and inhibits cardiomyocyte hypertrophy as well as collagen deposition. SGLT2-IN-2 can ameliorate myocardial tissue damage and enhance mitochondrial autophagy in injured cardiomyocytes, thereby increasing survival rates in HF mice .
Research Areas:
HD-TAC7 is a selective HDAC3 PROTAC degrader with an IC50 of 1.1 μM. By recruiting the CRBN E3 ligase, HD-TAC7 induces ubiquitin-proteasome degradation and selective downregulation of HDAC3, which in turn increases H3K27 acetylation levels and downregulates the NF-κB subunit p65, exerting anti-inflammatory activity. HD-TAC7 is used in research on COVID-19, SARS-CoV-2 infection, asthma, chronic obstructive pulmonary disease, and colon cancer .
Synonyms: TAC-101; Am 555S
Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with Ki of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer .
Research Areas:
Tz-Thalidomide is a tetrazine-tagged Thalidomide (HY-14658), an E3 ligase ligand. Tz-Thalidomide self-assembles with TCO-labeled target protein inhibitors, forming a CLIP-TAC (targeted protein degradation chimera) via click chemistry. This chimera recruits the E3 ubiquitin ligase CRBN to the target protein, thereby inducing ubiquitination and subsequent degradation of the target protein. When used in combination with JQ1-TCO (HY-148864), Tz-Thalidomide induces concentration-dependent degradation of BRD4 in cells. When combined with ERK-targeting protein inhibitors, Tz-Thalidomide induces degradation of ERK1/2 in cells. Tz-Thalidomide can be used in cancer-related research .
Cat. No.: HY-P990086
CAS No.: 2733581-99-0
Synonyms: RG-6292; RO-7296682
Target:
Research Areas:
Cat. No.: HY-175412
CAS No.: 142473-18-5
Synonyms: Dodecylmercapto-S-(poly(tris(hydroxymethyl)acrylamidomethane); H12-TAC
Target:
Research Areas:
DDTAC (H12-TAC) is a detergent that can extract and solubilize membrane proteins. DDTAC has a thio dodecanoyl chain linked to a polar group made of Tris polyalcoholic moieties and can be utilized in extracting yeast ATP synthase from mitochondrial membranes .
Cat. No.: HY-RS25124
Target:
Research Areas:
Tac1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tac1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-141599
CAS No.: 1853239-04-9
Synonyms: ADCT 301
Research Areas:
Cat. No.: HY-RS14136
Target:
Research Areas:
TAC1 Human Pre-designed siRNA Set A contains three designed siRNAs for TAC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS14137
Target:
Research Areas:
TAC3 Human Pre-designed siRNA Set A contains three designed siRNAs for TAC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS14138
Target:
Research Areas:
TAC4 Human Pre-designed siRNA Set A contains three designed siRNAs for TAC4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
