TGF-βRII

Pathways Recommended:	TGF-beta/Smad

By Targets:	Apoptosis (2) Collagen (1) EGFR (1) Endogenous Metabolite (2) p38 MAPK (2) Reactive Oxygen Species (ROS) (2) Reference Standards (1) TGF-beta/Smad (5) TGF-β Receptor (11)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0439

Asiaticoside 15+ Cited Publications	p38 MAPK TGF-beta/Smad Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses *TGF-β/Smad* signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties.

HY-13462

LY-364947 Maximum Cited Publications 24 Publications Verification HTS466284	TGF-β Receptor	Cancer
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC₅₀ of 59 nM, and exhibits 7-fold selectivity over TGFβR-II .

HY-13227

SD-208 5+ Cited Publications	TGF-β Receptor	Cancer
SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC₅₀ of 48 nM, and > 100-fold selectivity over TGF-βRII.

HY-P990957

Ficerafusp alfa BCA-101; FMAB2	EGFR TGF-beta/Smad	Inflammation/Immunology Cancer
Ficerafusp alfa (BCA-101) is a bispecific antibody targeting EGFR and TGFβ, with a K_d of 2.58 nM against EGFR and a K_d of 61.3 nM against TGFβ1. Ficerafusp alfa binds to EGFR, inhibits EGFR phosphorylation, blocks EGF-dependent cell proliferation, and mediates antibody-dependent cellular cytotoxicity against EGFR-positive tumor cells. Ficerafusp alfa sequesters TGFβ via its *TGFβRII* ECD domain, neutralizes the activity of TGFβ and TGFβ1, and blocks TGFβ-dependent processes, including epithelial-mesenchymal transition, cell invasion, and differentiation of inducible regulatory T cells. Ficerafusp alfa is applicable to research related to head and neck squamous cell carcinoma, advanced solid tumors, squamous non-small cell lung cancer, anal squamous cell carcinoma, colorectal cancer, and pancreatic cancer .

HY-P99480

Bintrafusp alfa M7824; MSB0011359C	TGF-β Receptor	Cancer
Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer .

HY-N0439R

Asiaticoside (Standard)	p38 MAPK Reference Standards TGF-beta/Smad Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Asiaticoside (Standard) is the analytical standard of Asiaticoside. This product is intended for research and analytical applications. Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties.

HY-N2589

Isosaponarin	TGF-β Receptor Collagen	Infection Metabolic Disease Inflammation/Immunology Cancer
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects .

HY-146693

CJJ300	TGF-β Receptor	Cancer
CJJ300 is a transforming growth factor-β (TGF-β) inhibitor with an IC₅₀ of 5.3 µM. CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex .

HY-161398

TGFβRII-IN-3	TGF-β Receptor TGF-beta/Smad	Cancer
TGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the **TGFβ type II receptor (TGFβ RII)** (IC₅₀ = 4.1 μM). TGFβRII-IN-3 inhibits TGFβ signaling by promoting the proteolytic degradation of TGFβ RII. TGFβRII-IN-3 can block endothelial-to-mesenchymal transition and cell migration. TGFβRII-IN-3 can be used in cancer research .

HY-114192

TGFβRI-IN-1	TGF-β Receptor	Cancer
TGFβRI-IN-1 is an oral active and selective TGFβ receptor type I (TGFβRI) kinase inhibitor, with IC₅₀ values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively .

HY-161400

TGFβRII-IN-2	TGF-β Receptor	Cancer
TGFβRII-IN-2 (Compound 3n) is an inhibitor for transforming growth factor-β type II receptor (*TGFβRII*) with IC₅₀** of 2.4 μM, which blocks endothelial-to-mesenchymal transition and cell migration in different cancer cell lines without perturbing the microtubule network .

HY-13227R

SD-208 (Standard)	TGF-β Receptor	Cancer
SD-208 (Standard) is the analytical standard of SD-208. This product is intended for research and analytical applications. SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, and > 100-fold selectivity over TGF-βRII.

HY-13227G

SD-208	TGF-β Receptor	Cancer
SD-208 (GMP) is SD-208 (HY-13227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC₅₀ of 48 nM, and > 100-fold selectivity over TGF-βRII.

HY-N17639

Regiafuran C	TGF-beta/Smad TGF-β Receptor	Others
Regiafuran C is a compound with both *TGF-βRI* inhibitory and anti-fibrotic activities. Regiafuran C effectively inhibits renal fibrosis by binding to *TGF-βRI* and interfering with the *TGF-β/Smad* and Wnt/β-catenin signaling pathways. Regiafuran C also exhibits free radical scavenging activity, but shows no anti-inflammatory activity in PGE2 competitive enzyme immunoassays. The ability of Regiafuran C to specifically block the *Smad3-TGF-βRII* interaction and inhibit fibrotic processes allows its use in renal fibrosis research .

Cat. No.	Product Name	Type

HY-13227G

SD-208	Fluorescent Dyes
SD-208 (GMP) is SD-208 (HY-13227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC₅₀ of 48 nM, and > 100-fold selectivity over TGF-βRII.

Cat. No.	Product Name	Type

HY-13227G

SD-208	Biochemical Assay Reagents
SD-208 (GMP) is SD-208 (HY-13227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC₅₀ of 48 nM, and > 100-fold selectivity over TGF-βRII.

Cat. No.	Product Name	Target	Research Area	Image

HY-P990957

Ficerafusp alfa BCA-101; FMAB2	EGFR TGF-beta/Smad	Inflammation/Immunology Cancer
Ficerafusp alfa (BCA-101) is a bispecific antibody targeting EGFR and TGFβ, with a K_d of 2.58 nM against EGFR and a K_d of 61.3 nM against TGFβ1. Ficerafusp alfa binds to EGFR, inhibits EGFR phosphorylation, blocks EGF-dependent cell proliferation, and mediates antibody-dependent cellular cytotoxicity against EGFR-positive tumor cells. Ficerafusp alfa sequesters TGFβ via its *TGFβRII* ECD domain, neutralizes the activity of TGFβ and TGFβ1, and blocks TGFβ-dependent processes, including epithelial-mesenchymal transition, cell invasion, and differentiation of inducible regulatory T cells. Ficerafusp alfa is applicable to research related to head and neck squamous cell carcinoma, advanced solid tumors, squamous non-small cell lung cancer, anal squamous cell carcinoma, colorectal cancer, and pancreatic cancer .

HY-P99480

Bintrafusp alfa M7824; MSB0011359C	TGF-β Receptor	Cancer
Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0439

Asiaticoside 15+ Cited Publications	Cardiovascular Disease Triterpenes Neurological Disease Classification of Application Fields Terpenoids Centella asiatica (L.) Urb. Umbelliferae Plants Endogenous metabolite Disease Research Fields Source Classification Cancer	p38 MAPK TGF-beta/Smad Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite
Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses *TGF-β/Smad* signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties.

HY-N0439R

Asiaticoside (Standard)	Triterpenes Structural Classification Terpenoids Centella asiatica (L.) Urb. Umbelliferae Plants Endogenous metabolite Source Classification	p38 MAPK Reference Standards TGF-beta/Smad Reactive Oxygen Species (ROS) Apoptosis Endogenous Metabolite
Asiaticoside (Standard) is the analytical standard of Asiaticoside. This product is intended for research and analytical applications. Asiaticoside, a trisaccaride triterpene from Centella asiatica, suppresses TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties.

HY-N2589

Isosaponarin	Flavonoids Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Flavones Other Diseases Phenols Polyphenols Plants Disease Research Fields Caryophyllaceae Source Classification	TGF-β Receptor Collagen
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects .

HY-N17639

Regiafuran C	Structural Classification Phenols Polyphenols Plants Moraceae Morus alba Linn. Source Classification	TGF-beta/Smad TGF-β Receptor
Regiafuran C is a compound with both *TGF-βRI* inhibitory and anti-fibrotic activities. Regiafuran C effectively inhibits renal fibrosis by binding to *TGF-βRI* and interfering with the *TGF-β/Smad* and Wnt/β-catenin signaling pathways. Regiafuran C also exhibits free radical scavenging activity, but shows no anti-inflammatory activity in PGE2 competitive enzyme immunoassays. The ability of Regiafuran C to specifically block the *Smad3-TGF-βRII* interaction and inhibit fibrotic processes allows its use in renal fibrosis research .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13227G

SD-208	TGF-β Receptor	Cancer
SD-208 (GMP) is SD-208 (HY-13227) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC₅₀ of 48 nM, and > 100-fold selectivity over TGF-βRII.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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TGF-βRII

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Inhibitory Antibodies

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GMP Molecules

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