2. TGF-beta/Smad
  3. TGF-β Receptor
  4. Bintrafusp alfa

Bintrafusp alfa  (Synonyms: M7824; MSB0011359C)

Cat. No.: HY-P99480 Purity: 97.96%
COA

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Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer.

For research use only. We do not sell to patients.

Bintrafusp alfa Chemical Structure

Bintrafusp alfa Chemical Structure

CAS No. : 1918149-01-5

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1 mg USD 400 In-stock
5 mg USD 1040 In-stock
10 mg USD 1665 In-stock
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Based on 1 publication(s) in Google Scholar

Bintrafusp alfa Related Antibodies

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Description

Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer[1].

In Vitro

Bintrafusp alfa can confer long-term protective immunity, decrease regulatory T-cell function, substantially increase CD8+ T cell and natural killer cell infiltration, and decrease myeloid-derived suppressor cell infiltration within tumors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bintrafusp alfa Related Antibodies
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Bintrafusp alfa]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 97.96%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Bintrafusp alfa Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bintrafusp alfa1918149-01-5M7824 MSB0011359CM 7824M-7824TGF-β ReceptorTransforming growth factor beta receptorsbifunctional fusion proteinTGF-βRIIIgG1mAbInhibitorinhibitorinhibit

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