Search Result

Isoforms Recommended:	TNFRSF1A/CD120a

Results for "

TNFR1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TNF Receptor (25) Antibiotic (1) Apoptosis (10) Aryl Hydrocarbon Receptor (1) Caspase (3) Cytochrome P450 (1) ERK (2) Flavivirus (4) Integrin (1) Interleukin Related (3) JNK (3) Mitochondrial Metabolism (1) NF-κB (10) p38 MAPK (4) PROTACs (1) RANKL/RANK (1) Reference Standards (1) Ser/Thr Kinase (1) Ser/Thr Protease (4) Small Interfering RNA (siRNA) (4) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (15) Infection (4) Inflammation/Immunology (21) Metabolic Disease (3) Neurological Disease (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (1) siRNAs (4)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: TNF Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9970

Infliximab 25+ Cited Publications Avakine; CT-P13; SB2; TA-650	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research ^[1] . The component ratio of this product is Active ingredient : Excipients = 9 : 47.

HY-160412

Balinatunfib SAR-441566; TNFα activity modulator 3	TNF Receptor	Inflammation/Immunology
Balinatunfib (SAR-441566) is an orally active inhibitor of *TNFR1* signaling. By binding to the central pocket of the soluble TNFα (sTNFα) trimer, Balinatunfib stabilizes an asymmetric conformation, blocking its binding to *TNFR1* (without affecting TNFR2) and thus inhibiting downstream pathways. Balinatunfib has anti-inflammatory activity, and can be used in the study of autoimmune diseases ^[1] .

HY-B0190A

Nafamostat mesylate 15+ Cited Publications FUT-175	Flavivirus TNF Receptor NF-κB Apoptosis Ser/Thr Protease	Infection Cancer
Nafamostat mesylate (FUT-175), an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat mesylate has anticancer and antivirus effect. Nafamostat mesylate induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat mesylate can be used in the development of the pathological thickening of the arterial wall ^[1] .

HY-111255

SPD304 5+ Cited Publications	TNF Receptor	Cancer
SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC₅₀ of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α ^[1] .

HY-134471

TNF-α-IN-2 1 Publications Verification	TNF Receptor	Inflammation/Immunology Cancer
TNF-α-IN-2 is a potent and orally active inhibitor of tumor necrosis factor alpha (TNFα), with an IC₅₀ of 25 nM in the HTRF assay. TNF-α-IN-2 distorts the TNFα trimer upon binding, leading to aberrant signaling when the trimer binds to TNFR1. TNF-α-IN-2 can be used for the research of rheumatoid arthritis ^[1].

HY-P9970A

Infliximab (Anti-TNF-α) Avakine (Anti-TNF-α); CT-P13 (Anti-TNF-α)	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Anti-TNF-α) (Avakine (Anti-TNF-α)) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab (Anti-TNF-α) prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab (Anti-TNF-α) has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research ^[1] .

HY-P991049

Atrosimab ATM-001	TNF Receptor	Metabolic Disease Inflammation/Immunology
Atrosimab is an Fv-Fc1K fusion protein with an EC₅₀ value of 0.37 nM against humans. Atrosimab inhibits TNF-induced TNFR1 activation, release of IL-6 and IL-8, and cell death, and alleviates neuroinflammation. Atrosimab is applicable to research related to inflammatory diseases, neurodegenerative diseases, acute and chronic inflammation, experimental arthritis, non-alcoholic steatohepatitis, and experimental autoimmune encephalomyelitis ^[1] .

HY-171658

R1-ICR-5	PROTACs Ser/Thr Kinase TNF Receptor Toll-like Receptor (TLR) NF-κB p38 MAPK	Inflammation/Immunology Cancer
R1-ICR-5 is a highly selective *RIPK1* PROTAC degrader. Mediated by VHL, R1-ICR-5 induces the degradation of RIPK1, which in turn dysregulates the *TNFR1* and TLR3/4 signaling hubs, enhances the signaling outputs of NF-κB, MAPK and IFN, and simultaneously promotes RIPK3 activation and necroptosis (necroptosis). R1-ICR-5 can be used in the research of triple-negative breast cancer and skin inflammation ^[1].

HY-P990008

Atrosab 1 Publications Verification	TNF Receptor Apoptosis	Inflammation/Immunology
Atrosab is a humanized IgG1 antagonistic anti-TNFR1 antibody. Atrosab inhibits TNF-mediated Apoptosis induction and IL-6 and IL-8 production. Atrosab reduces neurological deficits. Atrosab can be used for research of inflammatory disease. The recommend isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) ^[1] .

HY-P991400

GSK1995057	TNF Receptor Apoptosis Interleukin Related NF-κB JNK p38 MAPK	Inflammation/Immunology
GSK1995057 is a human monoclonal antibody (mAb) targeting *TNFRSF1A. GSK1995057 selectively binds to TNFR1, blocks the binding of TNF-α* and LT-α, and does not interfere with *TNFR2* signaling. GSK1995057 inhibits the activation of NF-κB, JNK and MAPK pathways, alleviates apoptosis (apoptosis) and inflammatory responses (inhibiting *IL-1β, IL-6, IL-10, TNF-α), and prevents viability loss of human nucleus pulposus cells. GSK1995057 inhibits the expression of cytokines and neutrophil adhesion molecules in human pulmonary microvascular endothelial cell monolayers, and reduces inflammatory responses and lung injury symptoms in non-human primates. GSK1995057 forms complexes with HAVH autoantibodies, thereby activating TNFR1* and triggering the release of cytokines and IL-8 in human cells. GSK1995057 can be used in research related to intervertebral disc degeneration and acute lung injury ^[1] .

HY-156454

UCB-6876	TNF Receptor	Inflammation/Immunology
UCB-6876 is a TNFα inhibitor. UCB-6876 specifically binds to the asymmetric crystalline form of TNF-α trimer with a K_D of 22 μM. UCB-6876 is applicable to research related to autoimmune diseases (rheumatoid arthritis and Crohn's disease) ^[1] .

HY-133807

Benpyrine 3 Publications Verification	TNF Receptor	Inflammation/Immunology
Benpyrine is a highly specific and orally active TNF-α inhibitor with a K_D value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC₅₀ value of 0.109 µM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research ^[1].

HY-111255A

SPD304 dihydrochloride 5+ Cited Publications	TNF Receptor	Inflammation/Immunology Cancer
SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC₅₀ of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α ^[1] .

HY-P11108

RP-182	NF-κB Apoptosis TNF Receptor Caspase	Inflammation/Immunology Cancer
RP-182 is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (K_d = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 ^high TAMs. RP-182 has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 is used in pancreatic cancer and melanoma research ^[1] .

HY-118922

IW927	TNF Receptor	Neurological Disease Inflammation/Immunology Cancer
IW927 is a photochemically enhanced *TNF-α-TNFR1* interaction inhibitor that blocks the binding of TNF-α to *TNFRc1* with an IC₅₀ value of 50 nM. IW927 binds reversibly to the *TNFRc1* with weak affinity (K_d = 40-100 μM), covalently modifies the receptor via a photochemical reaction, and does not bind the related cytokine receptors TNFRc2 or CD40. IW927 disrupts TNFα-induced IκB phosphorylation with an IC₅₀ value of 600 nM. IW927 can be used to develop light-independent inhibitors ^[1].

HY-P2612

WP9QY	TNF Receptor RANKL/RANK Apoptosis	Inflammation/Immunology
WP9QY is an inhibitor targeting TNFα and RANKL, which blocks the TNFα-TNFR1 interaction and inhibits TNFα-mediated apoptosis, cytotoxicity and bone destruction. WP9QY inhibits osteoclastogenesis and promotes osteoblast differentiation, induces chondrocyte proliferation and glycosaminoglycan production, and synergizes with TGF-β3 to promote chondrogenesis. WP9QY effectively repairs full-thickness articular cartilage defects in rabbits via intra-articular injection, and inhibits methylmercury-induced reduction of NeuN-positive cells in mouse brain slices. WP9QY can be applied to the research of diseases related to methylmercury-induced neuronal death, cartilage injury, osteoarthritis and bone loss ^[1] .

HY-124339

JNJ525	TNF Receptor	Neurological Disease Inflammation/Immunology Cancer
JNJ525 is a TNFα inhibitor with IC₅₀ values of 1.2 μM and 1.1 μM against *TNFR1* and *TNFR2, respectively. JNJ525 forms ordered aggregates and induces quaternary structural transition of TNFα, thereby blocking the protein-protein interaction between TNFα* and its receptors. The inhibitory activity of JNJ525 is completely lost in the presence of 0.1% Triton X-100 ^[1].

HY-B0190

Nafamostat	Flavivirus TNF Receptor NF-κB Apoptosis Ser/Thr Protease	Infection Cancer
Nafamostat, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat has anticancer and antivirus effect. Nafamostat induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat can be used in the development of the pathological thickening of the arterial wall ^[1] .

HY-B0190AR

Nafamostat mesylate (Standard) FUT-175 (Standard)	Flavivirus TNF Receptor NF-κB Apoptosis Ser/Thr Protease Reference Standards	Infection Cancer
Nafamostat (mesylate) (Standard) is the analytical standard of Nafamostat (mesylate). This product is intended for research and analytical applications. Nafamostat mesylate (FUT-175), an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat mesylate has anticancer and antivirus effect. Nafamostat mesylate induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat mesylate can be used in the development of the pathological thickening of the arterial wall ^[1] .

HY-P11214

Hydrostatin-TL1 H-TL1	TNF Receptor Integrin NF-κB ERK p38 MAPK JNK Interleukin Related	Inflammation/Immunology
Hydrostatin-TL1 (H-TL1), a nine-amino-acid peptide, is a TNF-α antagonist. Hydrostatin-TL1 can be isolated from the venom gland of sea snake Hydrophis cyanocinctus. H-TL1 competitively inhibits the interaction between TNF-α/TNFR1 and attenuates the cytotoxicity and inflammation of TNF-α. Hydrostatin-TL1 can be used for TNF-α-associated inflammatory diseases, such as rheumatoid arthritis, osteoporosis and inflammatory bowel disease (IBD) research ^[1].

HY-119420

Acetoxycycloheximide	Antibiotic Apoptosis Caspase JNK p38 MAPK TNF Receptor ERK NF-κB Mitochondrial Metabolism	Inflammation/Immunology Cancer
Acetoxycycloheximide is an antibiotic with antitumor activity. Acetoxycycloheximide a protein synthesis inhibitor. Acetoxycycloheximide significantly induces activation of procaspase-3 and subsequent apoptosis mediated by the Cytochrome c from mitochondria via activation of JNK pathway. Acetoxycycloheximide triggers the downregulation of cell surface *TNF-R1* via the activation of ERK and p38 MAPK, thereby preventing activation of the NF-κB signaling pathway by TNF-α. Acetoxycycloheximide is much more toxic to female rats than to males. Acetoxycycloheximide can be used for inflammatory and immune diseases and cancers research ^[1] .

HY-P11108A

RP-182 acetate	NF-κB Apoptosis TNF Receptor Caspase	Inflammation/Immunology Cancer
RP-182 acetate is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (K_d = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 acetate induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 ^high TAMs. RP-182 acetate has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 acetate is used in pancreatic cancer and melanoma research ^[1] .

HY-178053

AHR agonist 10	Aryl Hydrocarbon Receptor Cytochrome P450 Interleukin Related	Inflammation/Immunology
AHR agonist 10 is a potent AHR agonist (EC₅₀ = 2.01 nM). AHR agonist 10 can elevate the transcript levels of key AHR downstream pathway target genes, including *CYP1A1* and *CYP1B1. AHR agonist 10 can downregulate the expression levels of CD36, IL-18 and shows low cytotoxicity (>40 μM) to normal cells. AHR agonist 10 can suppress the expression of CCL5, CCL20, IL-6, IL-8, S100A9, TLR4, TNF-α, and TNFR1, demonstrating that AHR agonist 10 effectively modulate inflammatory responses through AHR* dependent signaling pathways. AHR agonist 10 can be used for psoriasis research ^[1].

HY-133807B

(R)-Benpyrine	TNF Receptor	Inflammation/Immunology
(R)-Benpyrine is the isomer of Benpyrine (HY-133807), and can be used as an experimental control. Benpyrine is a highly specific and orally active TNF-α inhibitor with a K_D value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC₅₀ value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research ^[1].

HY-B0190B

Nafamostat hydrochloride	Flavivirus TNF Receptor NF-κB Apoptosis Ser/Thr Protease	Infection Cancer
Nafamostat hydrochloride, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat hydrochloride has anticancer and antivirus effect. Nafamostat hydrochloride induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat hydrochloride can be used in the development of the pathological thickening of the arterial wall ^[1] .

HY-182884

TNF-α-IN-29	TNF Receptor	Inflammation/Immunology
TNF-α-IN-29 is an orally active and selective TNF-α inhibitor, with IC₅₀ values of 123.0 nM against human targets, and a human K_d of 45.9 nM. TNF-α-IN-29 blocks TNF-α-TNFR1 protein-protein interactions and inhibits TNF-α-mediated inflammatory signaling pathways. TNF-α-IN-29 exhibits anti-inflammatory effects in a mouse model of collagen-induced arthritis and promotes articular cartilage repair. TNF-α-IN-29 can be used for the research of rheumatoid arthritis ^[1].

HY-RS17435

Tnfrsf1b Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnfrsf1b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf1b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnfrsf1b Mouse Pre-designed siRNA Set A Tnfrsf1b Mouse Pre-designed siRNA Set A

HY-RS14810

TNFRSF1A Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TNFRSF1A Human Pre-designed siRNA Set A contains three designed siRNAs for TNFRSF1A gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TNFRSF1A Human Pre-designed siRNA Set A TNFRSF1A Human Pre-designed siRNA Set A

HY-RS23455

Tnfrsf1a Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnfrsf1a Rat Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf1a gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnfrsf1a Rat Pre-designed siRNA Set A Tnfrsf1a Rat Pre-designed siRNA Set A

HY-RS17012

Tnfrsf1a Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tnfrsf1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tnfrsf1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tnfrsf1a Mouse Pre-designed siRNA Set A Tnfrsf1a Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-P11108

RP-182	NF-κB Apoptosis TNF Receptor Caspase	Inflammation/Immunology Cancer
RP-182 is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (K_d = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 ^high TAMs. RP-182 has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 is used in pancreatic cancer and melanoma research ^[1] .

HY-P2612

WP9QY	TNF Receptor RANKL/RANK Apoptosis	Inflammation/Immunology
WP9QY is an inhibitor targeting TNFα and RANKL, which blocks the TNFα-TNFR1 interaction and inhibits TNFα-mediated apoptosis, cytotoxicity and bone destruction. WP9QY inhibits osteoclastogenesis and promotes osteoblast differentiation, induces chondrocyte proliferation and glycosaminoglycan production, and synergizes with TGF-β3 to promote chondrogenesis. WP9QY effectively repairs full-thickness articular cartilage defects in rabbits via intra-articular injection, and inhibits methylmercury-induced reduction of NeuN-positive cells in mouse brain slices. WP9QY can be applied to the research of diseases related to methylmercury-induced neuronal death, cartilage injury, osteoarthritis and bone loss ^[1] .

HY-P11214

Hydrostatin-TL1 H-TL1	TNF Receptor Integrin NF-κB ERK p38 MAPK JNK Interleukin Related	Inflammation/Immunology
Hydrostatin-TL1 (H-TL1), a nine-amino-acid peptide, is a TNF-α antagonist. Hydrostatin-TL1 can be isolated from the venom gland of sea snake Hydrophis cyanocinctus. H-TL1 competitively inhibits the interaction between TNF-α/TNFR1 and attenuates the cytotoxicity and inflammation of TNF-α. Hydrostatin-TL1 can be used for TNF-α-associated inflammatory diseases, such as rheumatoid arthritis, osteoporosis and inflammatory bowel disease (IBD) research ^[1].

HY-P11108A

RP-182 acetate	NF-κB Apoptosis TNF Receptor Caspase	Inflammation/Immunology Cancer
RP-182 acetate is a synthetic immunomodulatory peptide that exerts anti-tumor effects by targeting the mannose receptor CD206 (K_d = 8 μM) on the surface of tumor-associated macrophages (TAMs). RP-182 acetate induces a conformational switch of the CD206 receptor, which activates NF-κB signaling and phagocytosis in CD206 ^high TAMs. RP-182 acetate has dual function: activation of canonical NF-κB signaling, triggering TNFα secretion and autocrine activation of the TNF receptor 1 (TNFR1), leading to activation of caspase 8, apoptosis, and cell death. RP-182 acetate is used in pancreatic cancer and melanoma research ^[1] .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9970

Infliximab 25+ Cited Publications Avakine; CT-P13; SB2; TA-650	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research ^[1] . The component ratio of this product is Active ingredient : Excipients = 9 : 47.

HY-P9970A

Infliximab (Anti-TNF-α) Avakine (Anti-TNF-α); CT-P13 (Anti-TNF-α)	TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Infliximab (Anti-TNF-α) (Avakine (Anti-TNF-α)) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab (Anti-TNF-α) prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab (Anti-TNF-α) has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research ^[1] .

HY-P991049

Atrosimab ATM-001	TNF Receptor	Metabolic Disease Inflammation/Immunology
Atrosimab is an Fv-Fc1K fusion protein with an EC₅₀ value of 0.37 nM against humans. Atrosimab inhibits TNF-induced TNFR1 activation, release of IL-6 and IL-8, and cell death, and alleviates neuroinflammation. Atrosimab is applicable to research related to inflammatory diseases, neurodegenerative diseases, acute and chronic inflammation, experimental arthritis, non-alcoholic steatohepatitis, and experimental autoimmune encephalomyelitis ^[1] .

HY-P990008

Atrosab 1 Publications Verification	TNF Receptor Apoptosis	Inflammation/Immunology
Atrosab is a humanized IgG1 antagonistic anti-TNFR1 antibody. Atrosab inhibits TNF-mediated Apoptosis induction and IL-6 and IL-8 production. Atrosab reduces neurological deficits. Atrosab can be used for research of inflammatory disease. The recommend isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) ^[1] .

HY-P991400

GSK1995057	TNF Receptor Apoptosis Interleukin Related NF-κB JNK p38 MAPK	Inflammation/Immunology
GSK1995057 is a human monoclonal antibody (mAb) targeting *TNFRSF1A. GSK1995057 selectively binds to TNFR1, blocks the binding of TNF-α* and LT-α, and does not interfere with *TNFR2* signaling. GSK1995057 inhibits the activation of NF-κB, JNK and MAPK pathways, alleviates apoptosis (apoptosis) and inflammatory responses (inhibiting *IL-1β, IL-6, IL-10, TNF-α), and prevents viability loss of human nucleus pulposus cells. GSK1995057 inhibits the expression of cytokines and neutrophil adhesion molecules in human pulmonary microvascular endothelial cell monolayers, and reduces inflammatory responses and lung injury symptoms in non-human primates. GSK1995057 forms complexes with HAVH autoantibodies, thereby activating TNFR1* and triggering the release of cytokines and IL-8 in human cells. GSK1995057 can be used in research related to intervertebral disc degeneration and acute lung injury ^[1] .

Species:	Human (10) Mouse (3) Rat (2) Cynomolgus (1)
Tag:	His (8) Tag Free (3) Avi (2) Fc (5)
Source:	HEK293 (11) CHO (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70801

	TNF RI/TNFRSF1A Protein, Human (His) Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; TNFAR; TNFR1	Human	E. coli
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Human (His) is expressed by E. coli with a 6*His tag at the N-terminus.

HY-P700838

	TNF RI/TNFRSF1A Protein, Cynomolgus (HEK293, His) TNF-R1; TNF-RI; FPF; TBP1; TNF-R55; TNFAR; TNFR60; p55; p60; MS5; p55-R; TNFR1-d2	Cynomolgus	HEK293
	TNFRSF1A Protein exhibits a deficiency in conserved residue(s) crucial for feature annotation propagation. TNF RI/TNFRSF1A Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TNFRSF1A protein, expressed by HEK293 , with C-His labeled tag.

HY-P700263

	TNF RI/TNFRSF1A Protein, Human (HEK293, His) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Human	HEK293
	The TNFR-1/CD120a protein is a receptor for TNFSF2/TNF-α and TNFSF1/lymphotoxin-α, and initiates caspase-8-mediated apoptosis upon TNF binding. It induces non-cytocidal TNF action, activates acid sphingomyelinase and establishes an antiviral state. TNFR-1/CD120a Protein, Human (HEK293, His) is the recombinant human-derived TNFR-1/CD120a protein, expressed by HEK293 , with C-8*His labeled tag.

HY-P700264

	TNF RI/TNFRSF1A Protein, Human (HEK293, Fc) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Human	HEK293
	The TNFR-1/CD120a protein is a receptor for TNFSF2/TNF-α and TNFSF1/lymphotoxin-α, and initiates caspase-8-mediated apoptosis upon TNF binding. It induces non-cytocidal TNF action, activates acid sphingomyelinase and establishes an antiviral state. TNFR-1/CD120a Protein, Human (HEK293, Fc) is the recombinant human-derived TNFR-1/CD120a protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P702570

	TRADD Protein, Human (His) TNFR1 associated DEATH domain protein; TNFR1-associated DEATH domain protein; TNFRSF1A associated via death domain; TNFRSF1A-associated via death domain; tradd; TRADD_HUMAN; Tumor necrosis factor receptor type 1 associated DEATH domain protein; Tumor necrosis factor receptor type 1-associated DEATH domain protein	Human	E. coli
	The TRADD protein acts as a linker for TNFRSF1A/TNFR1 and mediates its interaction with FADD. TRADD induces TNF-induced responses: apoptosis and NF-kappa-B activation. TRADD Protein, Human (His) is the recombinant human-derived TRADD protein, expressed by E. coli , with C-6*His labeled tag.

HY-P74504

	TNF RI/TNFRSF1A Protein, Rat (HEK293, His) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Rat	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Rat (HEK293, His) is expressed by HEK293 and has a transmembrane region (M1-A211) with a His tag at the C-terminus.

HY-P72443

	TNF RI/TNFRSF1A Protein, Mouse Tumor necrosis factor receptor superfamily member 1A; TNF-R1; CD120a; TNFRsf1a	Mouse	E. coli
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse is expressed by E. coli and has a transmembrane region (I22-A212).

HY-P74505

	TNF RI/TNFRSF1A Protein, Rat (HEK293, Fc) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Rat	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Rat (HEK293, Fc) is expressed by HEK293 and has a transmembrane region with a Fc tag at the C-terminus.

HY-P73450

	TNF RI/TNFRSF1A Protein, Mouse (HEK293, His) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Mouse	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region with a His tag at the C-terminus.

HY-P73449

	TNF RI/TNFRSF1A Protein, Mouse (HEK293, Fc) Tumor necrosis factor receptor superfamily member 1A; CD120a; TNF-R1; TNFRSF1A	Mouse	HEK293
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse (HEK293, Fc) is expressed by HEK 293 cells and has a transmembrane region with a Fc tag at the C-terminus.

HY-P7305

	TNF RI/TNFRSF1A Protein, Human (CHO) rHuTNFRI; TNFRSF1A; TNFAR; CD120a	Human	CHO
	TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-κB, mediate apoptosis, and function as a regulator of inflammation. TNFRSF1A Protein, Human (CHO) is expressed by CHO and has a transmembrane region (D41-N201) .

HY-P78795

	TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His-Avi) TNFRSF1B; CD120b; TBPII; TNF-R-II; TNF-R75; TNFBR; TNFR1B; TNFR2; TNFR80; p75; p75TNFR	Human	HEK293
	The TNFRII protein is a receptor with high affinity for TNFSF2/TNF-α and low affinity for TNFSF1/lymphotoxin-α, and plays a key role in mediating the metabolic effects of TNF-α. The TRAF1/TRAF2 complex recruits BIRC2 and BIRC3 to TNFRSF1B/TNFR2 to regulate the apoptotic pathway. TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TNF RII/TNFRSF1B protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78526

	TNF RII/TNFRSF1B Protein, Human (HEK293, mFc) CD120b; Etanercept; p75TBPII; p75TNFR; TNF RII; TNF-R2; TNF-R75; TNFR80; TNFRSF1B; TNFR2; TBPII; TNFBR; TNFR1B	Human	HEK293
	TNFRII (TNFRSF1B) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRII has pro-apoptotic function. TNFRII recruits TRAF2, induces gene expression and intensively crosstalks with TNF-R1. TNFRII selectively enhances the induction of apoptosis by the death receptor TNFRI. TNF RII/TNFRSF1B Protein, Human (HEK293, mFc) is expressed by HEK293 and has a transmembrane region (M1-D257) with mFc tag at the C-terminus.

HY-P701084

	TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His) CD120b; Etanercept; p75TBPII; p75TNFR; TNF RII; TNF-R2; TNF-R75; TNFR80; TNFRSF1B; TNFR2; TBPII; TNFBR; TNFR1B	Human	HEK293
	The TNFRII protein is a receptor with high affinity for TNFSF2/TNF-α and low affinity for TNFSF1/lymphotoxin-α, and plays a key role in mediating the metabolic effects of TNF-α. The TRAF1/TRAF2 complex recruits BIRC2 and BIRC3 to TNFRSF1B/TNFR2 to regulate the apoptotic pathway. TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived TNF RII/TNFRSF1B protein, expressed by HEK293 , with C-His labeled tag.

HY-P705102

	TNF RII/TNFRSF1B Protein, Human (Biotinylated, HEK293, Fc-Avi) CD120b; Etanercept; p75TBPII; p75TNFR; TNF RII; TNF-R2; TNF-R75; TNFR80; TNFRSF1B; TNFR2; TBPII; TNFBR; TNFR1B	Human	HEK293

HY-P71914

	TNF RII/TNFRSF1B Protein, Human (183a.a) CD120b; p75; p75 TNF receptor; p75TNFR; p80 TNF alpha receptor; p80 TNF-alpha receptor; Soluble TNFR1B variant 1; TBP-2; TBPII; TNF R II; TNF R2; TNF R75; TNF-R2; TNF-RII; TNFBR; TNFR-II; TNFR1B; TNFR2; TNFR80; TNFRII ; TNFRsf1b; TNR1B_HUMAN; Tumor necrosis factor beta receptor; Tumor necrosis factor binding protein 2; Tumor necrosis factor receptor 2; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor type II; Tumor necrosis factor-binding protein 2	Human	E. coli
	The TNFRII protein is a receptor with high affinity for TNFSF2/TNF-α and low affinity for TNFSF1/lymphotoxin-α, and plays a key role in mediating the metabolic effects of TNF-α. The TRAF1/TRAF2 complex recruits BIRC2 and BIRC3 to TNFRSF1B/TNFR2 to regulate the apoptotic pathway. TNFRII Protein, Human (183a.a) is the recombinant human-derived TNFRII protein, expressed by E. coli , with tag free.

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Host:	Mouse (5) Rabbit (2)
Reactivity:	Human (6) mouse (1) Rat (2) Mouse (4) rat (1)
Application:	IHC-P (3) ICC/IF (5) IF-Tissue (1) IP (3) IHC-F (1) WB (5) FC (5) ELISA (5)
Isotype:	IgG (2) IgG1 (2) IgG2a (1) IgG2b (2)
Conjugation:	Non-conjugated (7) Biotin (3)
Clonality:	Polyclonal (1) Monoclonal (2) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82531

	TRADD Antibody (YA2276) AA930854; TNFR1 associated DEATH domain protein; tradd	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	TRADD Antibody (YA2276) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRADD.

HY-P84158

	TNFRSF1A Antibody (YA3855) FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55	ICC/IF, FC, ELISA	Human
	TNFRSF1A Antibody (YA3855) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TNFRSF1A.

HY-P84158A

	TNFRSF1A Antibody (YA3855)(PBS only) FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55	ICC/IF, FC, ELISA	Human
	TNFRSF1A Antibody (YA3855) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TNFRSF1A.

HY-P810217

	TNF-R1 Antibody (YA9561)	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	mouse, rat
	TNF-R1 Antibody (YA9561) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to TNF-R1.

HY-P80915

	TNF Receptor 2 Antibody CD120b; p75 TNF receptor; p80 TNF alpha receptor; Soluble TNFR1B variant 1; TBP-2; TBPII; TNF R75; TNFBR; TNFR-II; TNFR1B; TNFR2; TNFR80; TNFRII; TNFRsf1b	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat
	TNF Receptor 2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TNF Receptor 2.

HY-P84171

	TNF Receptor 2 Antibody (YA3868) TNFRSF1B; p75; TBPII; TNFBR; TNFR2; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II	WB, FC, ELISA	Human, Mouse
	TNF Receptor 2 Antibody (YA3868) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TNF Receptor 2.

HY-P84171A

	TNF Receptor 2 Antibody (YA3868)(PBS only) TNFRSF1B; p75; TBPII; TNFBR; TNFR2; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II	WB, FC, ELISA	Human, Mouse
	TNF Receptor 2 Antibody (YA3868) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TNF Receptor 2.